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image of Nutraceutical Interventions for Mitigating Skin Ageing: Analysis of Mechanisms and Efficacy

Abstract

Skin ageing is influenced by intrinsic factors such as genetics and hormones, as well as extrinsic factors like environmental exposure, ultraviolet (UV) radiation, and diet. These factors lead to biochemical, biological, and structural changes in the skin. Plant-derived compounds with antioxidant and anti-inflammatory properties have emerged as potential anti-ageing agents. This comprehensive review, spanning data from 1997 to 2024, explores the role of nutraceuticals in skin anti-ageing. The research data were drawn from Google, PubMed, PubMed Central, Scopus, and various journal databases, including ScienceDirect, Springer, and Taylor Francis. This review specifically examines plant-derived polyphenols, carotenoids, and other bioactive compounds, analysing their mechanisms through signalling pathways and cellular processes, using data from , , and clinical studies. Polyphenols like quercetin, curcumin, and epigallocatechin gallate (EGCG) have antioxidant and anti-inflammatory properties, helping to reduce oxidative stress, inflammation, UV-induced collagen degradation, and inflammatory cytokines. Notably, curcumin enhances collagen production and decreases the number of senescent cells. Carotenoids such as β-carotene, lutein, zeaxanthin, and lycopene protect against UV damage, and lycopene-rich tomato paste was specifically noted for its ability to reduce erythema and DNA damage. Additionally, compounds like resveratrol, fisetin, and wogonin exert protective effects against oxidative stress and inflammation, with resveratrol improving collagen synthesis and reducing the appearance of wrinkles. These plant-derived compounds can effectively combat skin ageing through various mechanisms, including the inhibition of oxidative stress, inflammation, and extracellular matrix degradation. They present a natural and sustainable approach to skincare in accord with the growing trend of conscious consumption. Future research should focus on understanding the long-term effects and determining the optimal dosage for clinical applications, highlighting the potential of integrating plant-based nutraceuticals into skincare regimens.

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2025-03-03
2025-03-28

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References

  1. Farage M.A. Miller K.W. Elsner P. Maibach H.I. Characteristics of the aging skin. Adv. Wound Care 2013 2 1 5 10 10.1089/wound.2011.0356 24527317
    [Google Scholar]
  2. Shah S.A. Oakes R.S. Jewell C.M. Advancing immunotherapy using biomaterials to control tissue, cellular, and molecular level immune signaling in skin. Adv. Drug Deliv. Rev. 2024 209 115315 10.1016/j.addr.2024.115315 38670230
    [Google Scholar]
  3. Powell J. Skin physiology. Women’s Heal. Medic. 2006 3 3 130 133 10.1383/wohm.2006.3.3.130
    [Google Scholar]
  4. Shin S.H. Lee Y.H. Rho N.K. Park K.Y. Skin aging from mechanisms to interventions: focusing on dermal aging. Front. Physiol. 2023 14 1195272 10.3389/fphys.2023.1195272 37234413
    [Google Scholar]
  5. Zhang S. Duan E. Fighting against Skin Aging. Cell Transplant. 2018 27 5 729 738 10.1177/0963689717725755 29692196
    [Google Scholar]
  6. Silva S.A.M.E. Michniak-Kohn B. Leonardi G.R. An overview about oxidation in clinical practice of skin ageing. An. Bras. Dermatol. 2017 92 3 367 374 10.1590/abd1806‑4841.20175481 29186250
    [Google Scholar]
  7. Farage M.A. Miller K.W. Berardesca E. Maibach H.I. Psychological and Social Implications of Ageing Skin: Normal Ageing and the Effects of Cutaneous Disease. Textbook of Ageing Skin. Farage M.A. Miller K.W. Maibach H.I. Berlin, Heidelberg Springer Berlin Heidelberg 2015 1 14 10.1007/978‑3‑642‑27814‑3_89‑2
    [Google Scholar]
  8. Shome D. Vadera S. Khare S. Ram M.S. Ayyar A. Kapoor R. Desai N. Aging and the indian face: an analytical study of aging in the asian indian face. Plast. Reconstr. Surg. Glob. Open 2020 8 3 e2580 10.1097/GOX.0000000000002580 32537318
    [Google Scholar]
  9. Ganceviciene R. Liakou A.I. Theodoridis A. Makrantonaki E. Zouboulis C.C. Skin anti-aging strategies. Dermatoendocrinol 2012 4 3 308 319 10.4161/derm.22804 23467476
    [Google Scholar]
  10. Medoro A Davinelli S Colletti A Di Micoli V Grandi E Fogacci F Nutraceuticals as modulators of immune function: a review of potential therapeutic effects. Prev. Nutr. Food Sci. 2023 38 2 89 107 10.3746/pnf.2023.28.2.89 37416796
    [Google Scholar]
  11. Beri K. Breathing to younger skin: ‘reversing the molecular mechanism of skin aging with yoga’. Future Sci. OA 2016 2 2 FSO122 10.4155/fsoa‑2016‑0015 28031969
    [Google Scholar]
  12. Halagali P Inamdar A Singh J Anand A Sadhu P Pathak R Phytochemicals, herbal extracts, and dietary supplements for metabolic disease management. Endocr. Metab. Immune. Disord. Drug. Targets. 2024 12 22 710 722 10.2174/0118715303287911240409055710 38676520
    [Google Scholar]
  13. Puri V. Nagpal M. Singh I. Singh M. Dhingra G.A. Huanbutta K. Dheer D. Sharma A. Sangnim T. A comprehensive review on nutraceuticals: therapy support and formulation challenges. Nutrients 2022 14 21 4637 10.3390/nu14214637 36364899
    [Google Scholar]
  14. Cao C. Xiao Z. Wu Y. Ge C. Diet and skin aging—from the perspective of food nutrition. Nutrients 2020 12 3 870 10.3390/nu12030870 32213934
    [Google Scholar]
  15. Steenvoorden D.P.T. Beijersbergen van Henegouwen G.M.J. The use of endogenous antioxidants to improve photoprotection. J. Photochem. Photobiol. B 1997 41 1-2 1 10 10.1016/S1011‑1344(97)00081‑X 9440308
    [Google Scholar]
  16. Gu Y. Han J. Jiang C. Zhang Y. Biomarkers, oxidative stress and autophagy in skin aging. Ageing Res. Rev. 2020 59 101036 10.1016/j.arr.2020.101036 32105850
    [Google Scholar]
  17. Vachon D.J. Yager D.R. 121 efficient sequestration of neutrophil‐derived proteases by a novel polymeric hydrogel. Wound Repair Regen. 2004 12 2 10.1111/j.1067‑1927.2004.0abstractdo.x
    [Google Scholar]
  18. Fitsiou E. Pulido T. Campisi J. Alimirah F. Demaria M. Cellular senescence and the senescence-associated secretory phenotype as drivers of skin photoaging. J. Invest. Dermatol. 2021 141 4 1119 1126 10.1016/j.jid.2020.09.031 33349436
    [Google Scholar]
  19. Son Y. Kim S. Chung H-T. Pae H-O. Reactive Oxygen Species in the Activation of MAP Kinases. Methods in Enzymology. New York Elsevier 2013 528 27 48 10.1016/B978‑0‑12‑405881‑1.00002‑1
    [Google Scholar]
  20. Fischer T.A. Ludwig S. Flory E. Gambaryan S. Singh K. Finn P. Pfeffer M.A. Kelly R.A. Pfeffer J.M. Activation of cardiac c-Jun NH(2)-terminal kinases and p38-mitogen-activated protein kinases with abrupt changes in hemodynamic load. Hypertension 2001 37 5 1222 1228 10.1161/01.HYP.37.5.1222 11358932
    [Google Scholar]
  21. Cabral-Pacheco G.A. Garza-Veloz I. Castruita-De la Rosa C. Ramirez-Acuña J.M. Perez-Romero B.A. Guerrero-Rodriguez J.F. Martinez-Avila N. Martinez-Fierro M.L. The roles of matrix metalloproteinases and their inhibitors in human diseases. Int. J. Mol. Sci. 2020 21 24 9739 10.3390/ijms21249739 33419373
    [Google Scholar]
  22. Kim K.S. Choi Y.J. Jang D.S. Lee S. 2-O-β-d-glucopyranosyl-4,6-dihydroxybenzaldehyde isolated from Morus alba (mulberry) fruits suppresses damage by regulating oxidative and inflammatory responses in tnf-α-induced human dermal fibroblasts. Int. J. Mol. Sci. 2022 23 23 14802 10.3390/ijms232314802 36499128
    [Google Scholar]
  23. Naylor E.C. Watson R.E.B. Sherratt M.J. Molecular aspects of skin ageing. Maturitas 2011 69 3 249 256 10.1016/j.maturitas.2011.04.011 21612880
    [Google Scholar]
  24. Quan T. Shao Y. He T. Voorhees J.J. Fisher G.J. Reduced expression of connective tissue growth factor (CTGF/CCN2) mediates collagen loss in chronologically aged human skin. J. Invest. Dermatol. 2010 130 2 415 424 10.1038/jid.2009.224 19641518
    [Google Scholar]
  25. He T. Quan T. Shao Y. Voorhees J.J. Fisher G.J. Oxidative exposure impairs TGF-β pathway via reduction of type II receptor and SMAD3 in human skin fibroblasts. Age (Omaha) 2014 36 3 9623 10.1007/s11357‑014‑9623‑6 24550076
    [Google Scholar]
  26. Wang A.S. Dreesen O. Biomarkers of cellular senescence and skin aging. Front. Genet. 2018 9 247 10.3389/fgene.2018.00247 30190724
    [Google Scholar]
  27. Shin J.W. Kwon S.H. Choi J.Y. Na J.I. Huh C.H. Choi H.R. Park K.C. Molecular mechanisms of dermal aging and antiaging approaches. Int. J. Mol. Sci. 2019 20 9 2126 10.3390/ijms20092126 31036793
    [Google Scholar]
  28. Michalak M. Plant-derived antioxidants: Significance in skin health and the ageing process. Int. J. Mol. Sci. 2022 23 2 585 10.3390/ijms23020585 35054770
    [Google Scholar]
  29. Hill A.B. International markets for genetic resources: Opportunities for Colombia. Int. J. Biotechnol. 2000 2 1/2/3 189 10.1504/IJBT.2000.000127
    [Google Scholar]
  30. Puri H.S. Neem: The Divine Tree Azadirachta indica (Medicinal and Aromatic Plants - Industrial Profiles Book 5). 1st Ed. Boca Raton CRC Press 1999 10.4324/9780203304310
    [Google Scholar]
  31. Amberg N. Fogarassy C. Green consumer behavior in the cosmetics market. Resources 2019 8 3 137 10.3390/resources8030137
    [Google Scholar]
  32. Hoang H.T. Moon J.Y. Lee Y.C. Natural antioxidants from plant extracts in skincare cosmetics: recent applications, challenges and perspectives. Cosmetics 2021 8 4 106 10.3390/cosmetics8040106
    [Google Scholar]
  33. Casale F. Suh S. Yale K. Atanaskova Mesinkovska N. Clinical role of oral vitamin C and E therapy in skin and hair disorders. Int. J. Cosmet. Dermatol. 2021 1 1 12 20 10.55124/ijcd.v1i1.44
    [Google Scholar]
  34. Soleymani S. Farzaei M.H. Zargaran A. Niknam S. Rahimi R. Promising plant-derived secondary metabolites for treatment of acne vulgaris: A mechanistic review. Arch. Dermatol. Res. 2020 312 1 5 23 10.1007/s00403‑019‑01968‑z 31448393
    [Google Scholar]
  35. Stephens TJ Sigler ML Hino PD Moigne AL Dispensa L. A Resveratrol-procyanidin blend: nutraceutical and antiageing efficacy evaluated in a placebo-controlled, double-blind study. Clin. Cosm. Inves. Derm. 2012 159 12084 10.1111/ics.12084
    [Google Scholar]
  36. Buonocore D. Cestone N. Bottone S. Marzatico L. SResveratrol-procyanidin blend: nutraceutical and antiageing efficacy evaluated in a placebo-controlled, double-blind study. Clin. Cosm. Inves. Derm. 2021 22 159 10.2147/CCID.S36102
    [Google Scholar]
  37. Csekes E. Račková L. Skin aging, cellular senescence and natural polyphenols. Int. J. Mol. Sci. 2021 22 23 12641 10.3390/ijms222312641 34884444
    [Google Scholar]
  38. Wahab S. Annadurai S. Abullais S.S. Das G. Ahmad W. Ahmad M.F. Kandasamy G. Vasudevan R. Ali M.S. Amir M. Glycyrrhiza glabra (Licorice): A comprehensive review on its phytochemistry, biological activities, clinical evidence and toxicology. Plants 2021 10 12 2751 10.3390/plants10122751 34961221
    [Google Scholar]
  39. Ciganović P. Jakimiuk K. Tomczyk M. Zovko Končić M. Glycerolic licorice extracts as active cosmeceutical ingredients: Extraction optimization, chemical characterization, and biological activity. Antioxidants 2019 8 10 445 10.3390/antiox8100445 31581512
    [Google Scholar]
  40. Pastorino G. Cornara L. Soares S. Rodrigues F. Oliveira M.B.P.P. Liquorice (Glycyrrhiza glabra ): A phytochemical and pharmacological review. Phytother. Res. 2018 32 12 2323 2339 10.1002/ptr.6178 30117204
    [Google Scholar]
  41. Häsler Gunnarsdottir S. Sommerauer L. Schnabel T. Oostingh G.J. Schuster A. Antioxidative and antimicrobial evaluation of bark extracts from common european trees in light of dermal applications. Antibiotics (Basel) 2023 12 1 130 10.3390/antibiotics12010130 36671331
    [Google Scholar]
  42. Marini A. Grether-Beck S. Jaenicke T. Weber M. Burki C. Formann P. Brenden H. Schönlau F. Krutmann J. Pycnogenol® effects on skin elasticity and hydration coincide with increased gene expressions of collagen type I and hyaluronic acid synthase in women. Skin Pharmacol. Physiol. 2012 25 2 86 92 10.1159/000335261 22270036
    [Google Scholar]
  43. Pinto C.A.S. Delfes M.F.Z. Reis L.M. Garbers L.E. Passos P.C.V.R. Torre D.S. The use of pycnogenol in the treatment of melasma. Surg. Cosmet. Dermatol. 2015 7 3 218 222 10.5935/scd1984‑8773.201573663
    [Google Scholar]
  44. Myung D.B. Lee J.H. Han H.S. Lee K.Y. Ahn H.S. Shin Y.K. Song E. Kim B.H. Lee K.H. Lee S.H. Lee K.T. Oral intake of Hydrangea serrata (Thunb.) Ser. leaves extract improves wrinkles, hydration, elasticity, texture, and roughness in human skin: a randomized, double-blind, placebo-controlled study. Nutrients 2020 12 6 1588 10.3390/nu12061588 32481760
    [Google Scholar]
  45. Yoon H.S. Kim J.R. Park G.Y. Kim J.E. Lee D.H. Lee K.W. Chung J.H. Cocoa flavanol supplementation influences skin conditions of photo-aged women: A 24-week double-blind, randomized, controlled trial. J. Nutr. 2016 146 1 46 50 10.3945/jn.115.217711 26581682
    [Google Scholar]
  46. Fam V.W. Holt R.R. Keen C.L. Sivamani R.K. Hackman R.M. Prospective evaluation of mango fruit intake on facial wrinkles and erythema in postmenopausal women: A randomized clinical pilot study. Nutrients 2020 12 11 3381 10.3390/nu12113381 33158079
    [Google Scholar]
  47. Ochocka R. Hering A. Stefanowicz-Hajduk J. Cal K. Barańska H. The effect of mangiferin on skin: Penetration, permeation and inhibition of ECM enzymes. PLoS One 2017 12 7 e0181542 10.1371/journal.pone.0181542 28750062
    [Google Scholar]
  48. Mallek-Ayadi S. Bahloul N. Baklouti S. Kechaou N. Bioactive compounds from Cucumis melo L. fruits as potential nutraceutical food ingredients and juice processing using membrane technology. Food Sci. Nutr. 2022 10 9 2922 2934 10.1002/fsn3.2888 36171790
    [Google Scholar]
  49. Fam V.W. Charoenwoodhipong P. Sivamani R.K. Holt R.R. Keen C.L. Hackman R.M. Plant-based foods for skin health: A narrative review. J. Acad. Nutr. Diet. 2022 122 3 614 629 10.1016/j.jand.2021.10.024 34728412
    [Google Scholar]
  50. Puglia C. Offerta A. Saija A. Trombetta D. Venera C. Protective effect of red orange extract supplementation against UV ‐induced skin damages: photoaging and solar lentigines. J. Cosmet. Dermatol. 2014 13 2 151 157 10.1111/jocd.12083 24910279
    [Google Scholar]
  51. Toma R.B. Frank G.C. Nakayama K. Tawfik E. Lycopene content in raw tomato varieties and tomato products. J. Foodserv. 2008 19 2 127 132 10.1111/j.1745‑4506.2008.00094.x
    [Google Scholar]
  52. Lin W. Wu R.T. Wu T. Khor T.O. Wang H. Kong A.N. Sulforaphane suppressed LPS-induced inflammation in mouse peritoneal macrophages through Nrf2 dependent pathway. Biochem. Pharmacol. 2008 76 8 967 973 10.1016/j.bcp.2008.07.036 18755157
    [Google Scholar]
  53. Meinke M. Nowbary C. Schanzer S. Vollert H. Lademann J. Darvin M. Influences of orally taken carotenoid-rich curly kale extract on collagen I/elastin index of the skin. Nutrients 2017 9 7 775 10.3390/nu9070775
    [Google Scholar]
  54. Kang S.J. Choi B.R. Kim S.H. Yi H.Y. Park H.R. Song C.H. Ku S.K. Lee Y.J. Beneficial effects of dried pomegranate juice concentrated powder on ultraviolet B-induced skin photoaging in hairless mice. Exp. Ther. Med. 2017 14 2 1023 1036 10.3892/etm.2017.4626 28810554
    [Google Scholar]
  55. Kim I.S. Current perspectives on the beneficial effects of soybean isoflavones and their metabolites for humans. Antioxidants 2021 10 7 1064 10.3390/antiox10071064 34209224
    [Google Scholar]
  56. Izumi T. Saito M. Obata A. Arii M. Yamaguchi H. Matsuyama A. Oral intake of soy isoflavone aglycone improves the aged skin of adult women. J. Nutr. Sci. Vitaminol. (Tokyo) 2007 53 1 57 62 10.3177/jnsv.53.57 17484381
    [Google Scholar]
  57. Terazawa S. Nakajima H. Tobita K. Imokawa G. The decreased secretion of hyaluronan by older human fibroblasts under physiological conditions is mainly associated with the down-regulated expression of hyaluronan synthases but not with the expression levels of hyaluronidases. Cytotechnology 2015 67 4 609 620 10.1007/s10616‑014‑9707‑2 24590928
    [Google Scholar]
  58. OyetakinWhite P. Tribout H. Baron E. Protective mechanisms of green tea polyphenols in skin. Oxid. Med. Cell. Longev. 2012 2012 1 8 10.1155/2012/560682
    [Google Scholar]
  59. Di Sotto A. Gullì M. Percaccio E. Vitalone A. Mazzanti G. Di Giacomo S. Efficacy and safety of oral green tea preparations in skin ailments: A systematic review of clinical studies. Nutrients 2022 14 15 3149 10.3390/nu14153149 35956325
    [Google Scholar]
  60. Kim E. Hwang K. Lee J. Han S.Y. Kim E.M. Park J. Cho J.Y. Skin protective effect of epigallocatechin gallate. Int. J. Mol. Sci. 2018 19 1 173 10.3390/ijms19010173 29316635
    [Google Scholar]
  61. Saffari Y. Sadrzadeh S.M.H. Green tea metabolite EGCG protects membranes against oxidative damage in vitro. Life Sci. 2004 74 12 1513 1518 10.1016/j.lfs.2003.08.019 14729400
    [Google Scholar]
  62. Younes M. Aggett P. Aguilar F. Crebelli R. Dusemund B. Filipič M. Frutos M.J. Galtier P. Gott D. Gundert-Remy U. Lambré C. Leblanc J.C. Lillegaard I.T. Moldeus P. Mortensen A. Oskarsson A. Stankovic I. Waalkens-Berendsen I. Woutersen R.A. Andrade R.J. Fortes C. Mosesso P. Restani P. Arcella D. Pizzo F. Smeraldi C. Wright M. Scientific opinion on the safety of green tea catechins. EFSA J. 2018 16 4 e05239 10.2903/j.efsa.2018.5239 32625874
    [Google Scholar]
  63. Ibrahim M Parveen B Zahiruddin S Gautam G Parveen R Khan MA Analysis of polyphenols in Aegle marmelos leaf and ameliorative efficacy against diabetic mice through restoration of antioxidant and anti-inflammatory status J Food Biochem. 2022 46 4 e13852 10.1111/jfbc.13852 34250628
    [Google Scholar]
  64. Flora S.J.S. Structural, chemical and biological aspects of antioxidants for strategies against metal and metalloid exposure. Oxid. Med. Cell. Longev. 2009 2 4 191 206 10.4161/oxim.2.4.9112 20716905
    [Google Scholar]
  65. Liguori I Russo G Curcio F Bulli G Aran L Della-Morte D Oxidative stress, ageing, and diseases. Clin Interv Aging. 2018 26 13 757 775 10.2147/CIA.S158513 29731617
    [Google Scholar]
  66. Rahman A. Ibrahim M. Siddiqui J.I. Ansari S.A. Ahmad S. Metabolomic profiling and antidiabetic potential of Rumex vesicarius seed extract in high-fat diet and streptozotocin-induced diabeticrat. Clin. Interv. Aging 2022 58 e21032 10.2147/CIA.S158513
    [Google Scholar]
  67. Bao D. Wang J. Pang X. Liu H. Protective effect of quercetin against oxidative stress-induced cytotoxicity in rat pheochromocytoma (PC-12) cells. Molecules 2017 22 7 1122 10.3390/molecules22071122 28684704
    [Google Scholar]
  68. Parasuraman S. Anand David A.V. Arulmoli R. Overviews of biological importance of quercetin: A bioactive flavonoid. Pharmacogn. Rev. 2016 10 20 84 89 10.4103/0973‑7847.194044 28082789
    [Google Scholar]
  69. Shin E.J. Lee J.S. Hong S. Lim T.G. Byun S. Quercetin directly targets JAK2 and PKCΔ and prevents uv-induced photoaging in human skin. Int. J. Mol. Sci. 2019 20 21 5262 10.3390/ijms20215262 31652815
    [Google Scholar]
  70. López-Camarillo C. Aréchaga Ocampo E. López Casamichana M. Pérez-Plasencia C. Álvarez-Sánchez E. Marchat L.A. Protein kinases and transcription factors activation in response to UV-radiation of skin: implications for carcinogenesis. Int. J. Mol. Sci. 2011 13 1 142 172 10.3390/ijms13010142 22312244
    [Google Scholar]
  71. Cai W. Yu D. Fan J. Liang X. Jin H. Liu C. Zhu M. Shen T. Zhang R. Hu W. Wei Q. Yu J. Quercetin inhibits transforming growth factor β1-induced epithelial–mesenchymal transition in human retinal pigment epithelial cells via the Smad pathway. Drug Des. Devel. Ther. 2018 12 4149 4161 10.2147/DDDT.S185618 30584279
    [Google Scholar]
  72. Amalraj A. Pius A. Gopi S. Gopi S. Biological activities of curcuminoids, other biomolecules from turmeric and their derivatives – A review. J. Tradit. Complement. Med. 2017 7 2 205 233 10.1016/j.jtcme.2016.05.005 28417091
    [Google Scholar]
  73. Menon V.P. Sudheer A.R. Antioxidant and Anti-Inflammatory Properties of Curcumin. The Molecular Targets and Therapeutic Uses of Curcumin in Health and Disease. Aggarwal B.B. Surh Y-J. Shishodia S. Boston, MA Springer US 2007 Vol. 595 105 125 10.1007/978‑0‑387‑46401‑5_3
    [Google Scholar]
  74. Zia A. Farkhondeh T. Pourbagher-Shahri A.M. Samarghandian S. The role of curcumin in aging and senescence: Molecular mechanisms. Biomed. Pharmacother. 2021 134 111119 10.1016/j.biopha.2020.111119 33360051
    [Google Scholar]
  75. Bielak-Zmijewska A. Grabowska W. Ciolko A. Bojko A. Mosieniak G. Bijoch Ł. Role of curcumin in the modulation of ageing. Int. J. Mol. Sci. 2019 20 5 1239 10.3390/ijms20051239 30871021
    [Google Scholar]
  76. Jia Y. Mao Q. Yang J. Du N. Zhu Y. Min W. (–)-Epigallocatechin-3-gallate protects human skin fibroblasts from ultraviolet a induced photoaging. Clin. Cosmet. Investig. Dermatol. 2023 16 149 159 10.2147/CCID.S398547 36704608
    [Google Scholar]
  77. Kubatka P. Mazurakova A. Samec M. Koklesova L. Zhai K. AL-Ishaq R. Kajo K. Biringer K. Vybohova D. Brockmueller A. Pec M. Shakibaei M. Giordano F.A. Büsselberg D. Golubnitschaja O. Flavonoids against non-physiologic inflammation attributed to cancer initiation, development, and progression—3PM pathways. EPMA J. 2021 12 4 559 587 10.1007/s13167‑021‑00257‑y 34950252
    [Google Scholar]
  78. Pal H.C. Hunt K.M. Diamond A. Elmets C.A. Afaq F. Phytochemicals for the management of melanoma. Mini Rev. Med. Chem. 2016 16 12 953 979 10.2174/1389557516666160211120157 26864554
    [Google Scholar]
  79. Zhao H. Zhu W. Zhao X. Li X. Zhou Z. Zheng M. Meng X. Kong L. Zhang S. He D. Xing L. Yu J. Efficacy of epigallocatechin-3-gallate in preventing dermatitis in patients with breast cancer receiving postoperative radiotherapy. JAMA Dermatol. 2022 158 7 779 786 10.1001/jamadermatol.2022.1736 35648426
    [Google Scholar]
  80. Savaskan E. Olivieri G. Meier F. Seifritz E. Wirz-Justice A. Müller-Spahn F. Red wine ingredient resveratrol protects from β-amyloid neurotoxicity. Gerontology 2003 49 6 380 383 10.1159/000073766 14624067
    [Google Scholar]
  81. Pérez-Sánchez A. Barrajón-Catalán E. Herranz-López M. Micol V. Nutraceuticals for skin care: A comprehensive review of human clinical studies. Nutrients 2018 10 4 403 10.3390/nu10040403 29587342
    [Google Scholar]
  82. Leis K. Pisanko K. Jundziłł A. Mazur E. Męcińska-Jundziłł K. Witmanowski H. Resveratrol as a factor preventing skin aging and affecting its regeneration. Postepy Dermatol. Alergol. 2022 39 3 439 445 10.5114/ada.2022.117547 35950117
    [Google Scholar]
  83. Cnubben N.H.P. Rietjens I.M.C.M. Wortelboer H. van Zanden J. van Bladeren P.J. The interplay of glutathione-related processes in antioxidant defense. Environ. Toxicol. Pharmacol. 2001 10 4 141 152 10.1016/S1382‑6689(01)00077‑1 21782570
    [Google Scholar]
  84. Zhang L.X. Li C.X. Kakar M.U. Khan M.S. Wu P.F. Amir R.M. Dai D.F. Naveed M. Li Q.Y. Saeed M. Shen J.Q. Rajput S.A. Li J.H. Resveratrol (RV): A pharmacological review and call for further research. Biomed. Pharmacother. 2021 143 112164 10.1016/j.biopha.2021.112164 34649335
    [Google Scholar]
  85. Xu L. Botchway B.O.A. Zhang S. Zhou J. Liu X. Inhibition of NF-κB signaling pathway by resveratrol improves spinal cord injury. Front. Neurosci. 2018 12 690 10.3389/fnins.2018.00690 30337851
    [Google Scholar]
  86. Lephart E.D. Phytoestrogens (resveratrol and equol) for estrogen-deficient skin—controversies/misinformation versus anti-aging in vitro and clinical evidence via nutraceutical-cosmetics. Int. J. Mol. Sci. 2021 22 20 11218 10.3390/ijms222011218 34681876
    [Google Scholar]
  87. Chang H.C. Chen T.G. Tai Y.T. Chen T.L. Chiu W.T. Chen R.M. Resveratrol attenuates oxidized LDL-evoked Lox-1 signaling and consequently protects against apoptotic insults to cerebrovascular endothelial cells. J. Cereb. Blood Flow Metab. 2011 31 3 842 854 10.1038/jcbfm.2010.180 20940732
    [Google Scholar]
  88. Caldas A.R. Catita J. Machado R. Ribeiro A. Cerqueira F. Horta B. Medeiros R. Lúcio M. Lopes C.M. Omega-3- and resveratrol-loaded lipid nanosystems for potential use as topical formulations in autoimmune, inflammatory, and cancerous skin diseases. Pharmaceutics 2021 13 8 1202 10.3390/pharmaceutics13081202 34452163
    [Google Scholar]
  89. Seo S.H. Jeong G.S. Fisetin inhibits TNF-α-induced inflammatory action and hydrogen peroxide-induced oxidative damage in human keratinocyte HaCaT cells through PI3K/AKT/Nrf-2-mediated heme oxygenase-1 expression. Int. Immunopharmacol. 2015 29 2 246 253 10.1016/j.intimp.2015.11.014 26590114
    [Google Scholar]
  90. Wu P-Y Lyu J-L Liu Y-J Chien T-Y Hsu H-C Wen K-C Fisetin regulates Nrf2 expression and the inflammation-related signaling pathway to prevent uvb-induced skin damage in hairless mice. Int J Mol Sci. 2017 18 10 2118 10.3390/ijms18102118 28994699
    [Google Scholar]
  91. Chi Y.S. Kim H.P. Suppression of cyclooxygenase-2 expression of skin fibroblasts by wogonin, a plant flavone from Scutellaria radix. Prostaglandins Leukot. Essent. Fatty Acids 2005 72 1 59 66 10.1016/j.plefa.2004.04.009 15589400
    [Google Scholar]
  92. Chi Y.S. Lim H. Park H. Kim H.P. Effects of wogonin, a plant flavone from Scutellaria radix, on skin inflammation: in vivo regulation of inflammation-associated gene expression. Biochem. Pharmacol. 2003 66 7 1271 1278 10.1016/S0006‑2952(03)00463‑5 14505806
    [Google Scholar]
  93. Swanson D. Block R. Mousa S.A. Omega-3 fatty acids EPA and DHA: health benefits throughout life. Adv. Nutr. 2012 3 1 1 7 10.3945/an.111.000893 22332096
    [Google Scholar]
  94. Calder P.C. Omega-3 fatty acids and inflammatory processes. Nutrients 2010 2 3 355 374 10.3390/nu2030355 22254027
    [Google Scholar]
  95. Araujo P. Belghit I. Aarsæther N. Espe M. Lucena E. Holen E. The effect of omega-3 and omega-6 polyunsaturated fatty acids on the production of cyclooxygenase and lipoxygenase metabolites by human umbilical vein endothelial cells. Nutrients 2019 11 5 966 10.3390/nu11050966 31035600
    [Google Scholar]
  96. Huang T.H. Wang P.W. Yang S.C. Chou W.L. Fang J.Y. Cosmetic and therapeutic applications of fish oil’s fatty acids on the skin. Mar. Drugs 2018 16 8 256 10.3390/md16080256 30061538
    [Google Scholar]
  97. Parke M.A. Perez-Sanchez A. Zamil D.H. Katta R. Diet and skin barrier: the role of dietary interventions on skin barrier function. Dermatol. Pract. Concept. 2021 11 1 e2021132 10.5826/dpc.1101a132 33614213
    [Google Scholar]
  98. Purnamawati S. Indrastuti N. Danarti R. Saefudin T. The role of moisturizers in addressing various kinds of dermatitis: a review. Clin. Med. Res. 2017 15 3-4 75 87 10.3121/cmr.2017.1363 29229630
    [Google Scholar]
  99. Kakoti B.B. Hernandez-Ontiveros D.G. Kataki M.S. Shah K. Pathak Y. Panguluri S.K. Resveratrol and omega-3 fatty acid: Its implications in cardiovascular diseases. Front. Cardiovasc. Med. 2015 2 38 10.3389/fcvm.2015.00038 26697434
    [Google Scholar]
  100. Larson M.K. Shearer G.C. Ashmore J.H. Anderson-Daniels J.M. Graslie E.L. Tholen J.T. Vogelaar J.L. Korth A.J. Nareddy V. Sprehe M. Harris W.S. Omega-3 fatty acids modulate collagen signaling in human platelets. Prostaglandins Leukot. Essent. Fatty Acids 2011 84 3-4 93 98 10.1016/j.plefa.2010.11.004 21177087
    [Google Scholar]
  101. Michalak M. Pierzak M. Kręcisz B. Suliga E. Bioactive compounds for skin health: A review. Nutrients 2021 13 1 203 10.3390/nu13010203 33445474
    [Google Scholar]
  102. Troesch B. Eggersdorfer M. Laviano A. Rolland Y. Smith A.D. Warnke I. Weimann A. Calder P.C. Expert opinion on benefits of long-chain omega-3 fatty acids (DHA and EPA) in aging and clinical nutrition. Nutrients 2020 12 9 2555 10.3390/nu12092555 32846900
    [Google Scholar]
  103. Sawada Y. Saito-Sasaki N. Nakamura M. Omega 3 fatty acid and skin diseases. Front. Immunol. 2021 11 623052 10.3389/fimmu.2020.623052 33613558
    [Google Scholar]
  104. Darvin M.E. Lademann J. von Hagen J. Lohan S.B. Kolmar H. Meinke M.C. Jung S. Carotenoids in human skin in vivo: Antioxidant and photo-protectant role against external and internal stressors. Antioxidants 2022 11 8 1451 10.3390/antiox11081451 35892651
    [Google Scholar]
  105. Fiedor J. Burda K. Potential role of carotenoids as antioxidants in human health and disease. Nutrients 2014 6 2 466 488 10.3390/nu6020466 24473231
    [Google Scholar]
  106. Balić A. Mokos M. Do we utilize our knowledge of the skin protective effects of carotenoids enough? Antioxidants 2019 8 8 259 10.3390/antiox8080259 31370257
    [Google Scholar]
  107. Grether-Beck S. Marini A. Jaenicke T. Stahl W. Krutmann J. Molecular evidence that oral supplementation with lycopene or lutein protects human skin against ultraviolet radiation: results from a double-blinded, placebo-controlled, crossover study. Br. J. Dermatol. 2017 176 5 1231 1240 10.1111/bjd.15080 27662341
    [Google Scholar]
  108. Juturu V. Bowman J. Deshpande J. Overall skin tone and skin-lightening-improving effects with oral supplementation of lutein and zeaxanthin isomers: a double-blind, placebo-controlled clinical trial. Clin. Cosmet. Investig. Dermatol. 2016 9 325 332 10.2147/CCID.S115519 27785083
    [Google Scholar]
  109. Palombo P. Fabrizi G. Ruocco V. Ruocco E. Fluhr J. Roberts R. Morganti P. Beneficial long-term effects of combined oral/topical antioxidant treatment with the carotenoids lutein and zeaxanthin on human skin: a double-blind, placebo-controlled study. Skin Pharmacol. Physiol. 2007 20 4 199 210 10.1159/000101807 17446716
    [Google Scholar]
  110. Ascenso A. Pedrosa T. Pinho S. Pinho F. Oliveira J.M.P.F. Cabral Marques H. Oliveira H. Simões S. Santos C. The effect of lycopene preexposure on UV‐b‐irradiated human keratinocytes. Oxid. Med. Cell. Longev. 2016 2016 1 8214631 10.1155/2016/8214631 26664697
    [Google Scholar]
  111. Parrado C. Philips N. Gilaberte Y. Juarranz A. González S. Oral photoprotection: effective agents and potential candidates. Front. Med. 2018 5 188 10.3389/fmed.2018.00188 29998107
    [Google Scholar]
  112. Northrop-Clewes C.A. Thurnham D.I. Vitamins. The Nutrition Handbook for Food Processors. New york Elsevier 2002 34 96 10.1533/9781855736658.1.34
    [Google Scholar]
  113. Ferrari S. Bonjour J.P. Rizzoli R. The vitamin d receptor gene and calcium metabolism. Trends Endocrinol. Metab. 1998 9 7 259 265 10.1016/S1043‑2760(98)00065‑4 18406281
    [Google Scholar]
  114. VanBuren C.A. Everts H.B. Vitamin A in skin and hair: An update. Nutrients 2022 14 14 2952 10.3390/nu14142952 35889909
    [Google Scholar]
  115. Stahl W. Sies H. β-Carotene and other carotenoids in protection from sunlight. Am. J. Clin. Nutr. 2012 96 5 1179S 1184S 10.3945/ajcn.112.034819 23053552
    [Google Scholar]
  116. Thielitz A. Gollnick H. Topical retinoids in acne vulgaris: Update on efficacy and safety. Am. J. Clin. Dermatol. 2008 9 6 369 381 10.2165/0128071‑200809060‑00003 18973403
    [Google Scholar]
  117. Chivot M. Retinoid therapy for acne. A comparative review. Am. J. Clin. Dermatol. 2005 6 1 13 19 10.2165/00128071‑200506010‑00002 15675886
    [Google Scholar]
  118. Ioannides D. Rigopoulos D. Katsambas A. Topical adapalene gel 0.1% vs. isotretinoin gel 0.05% in the treatment of acne vulgaris: A randomized open-label clinical trial. Br. J. Dermatol. 2002 147 3 523 527 10.1046/j.1365‑2133.2002.04873.x 12207595
    [Google Scholar]
  119. Bagatin E. Costa C.S. The use of isotretinoin for acne – an update on optimal dosing, surveillance, and adverse effects. Expert Rev. Clin. Pharmacol. 2020 13 8 885 897 10.1080/17512433.2020.1796637 32744074
    [Google Scholar]
  120. Leung A.K.C. Barankin B. Lam J.M. Leong K.F. Hon K.L. Dermatology: how to manage acne vulgaris. Drugs Context 2021 10 1 18 10.7573/dic.2021‑8‑6 34691199
    [Google Scholar]
  121. Cook M.K. Perche P.O. Feldman S.R. The use of oral vitamin A in acne management: A review. Dermatol. Online J. 2022 28 5 10.5070/D328559239 36809126
    [Google Scholar]
  122. Kennedy D. B vitamins and the brain: mechanisms, dose and efficacy—a review. Nutrients 2016 8 2 68 10.3390/nu8020068 26828517
    [Google Scholar]
  123. Chaudhary P. Janmeda P. Docea A.O. Yeskaliyeva B. Abdull Razis A.F. Modu B. Calina D. Sharifi-Rad J. Oxidative stress, free radicals and antioxidants: Potential crosstalk in the pathophysiology of human diseases. Front Chem. 2023 11 1158198 10.3389/fchem.2023.1158198 37234200
    [Google Scholar]
  124. Pullar J. Carr A. Vissers M. The roles of vitamin C in skin health. Nutrients 2017 9 8 866 10.3390/nu9080866 28805671
    [Google Scholar]
  125. Mostafa W.Z. Hegazy R.A. Vitamin D and the skin: Focus on a complex relationship: A review. J. Adv. Res. 2015 6 6 793 804 10.1016/j.jare.2014.01.011 26644915
    [Google Scholar]
  126. Bocheva G. Slominski R.M. Slominski A.T. The impact of vitamin D on skin aging. Int. J. Mol. Sci. 2021 22 16 9097 10.3390/ijms22169097 34445803
    [Google Scholar]
  127. Janjetovic Z. Slominski A.T. Promising functions of novel vitamin D derivatives as cosmetics: A new fountain of youth in skin aging and skin protection. Cosmetics 2024 11 2 37 10.3390/cosmetics11020037
    [Google Scholar]
  128. Keen M. Hassan I. Vitamin E in dermatology. Indian Dermatol. Online J. 2016 7 4 311 315 10.4103/2229‑5178.185494 27559512
    [Google Scholar]
  129. Muzumdar S. Ferenczi K. Nutrition and youthful skin. Clin. Dermatol. 2021 39 5 796 808 10.1016/j.clindermatol.2021.05.007 34785007
    [Google Scholar]
  130. Weyh C. Krüger K. Peeling P. Castell L. The role of minerals in the optimal functioning of the immune system. Nutrients 2022 14 3 644 10.3390/nu14030644 35277003
    [Google Scholar]
  131. Salvo J. Sandoval C. Role of copper nanoparticles in wound healing for chronic wounds: Literature review. Burns Trauma 2022 10 tkab047 10.1093/burnst/tkab047 35071652
    [Google Scholar]
  132. Ogen-Shtern N. Chumin K. Cohen G. Borkow G. Increased pro‐collagen 1, elastin, and TGF‐β1 expression by copper ions in an ex‐vivo human skin model. J. Cosmet. Dermatol. 2020 19 6 1522 1527 10.1111/jocd.13186 31603269
    [Google Scholar]
  133. Rinnerthaler M. Streubel M.K. Bischof J. Richter K. Skin aging, gene expression and calcium. Exp. Gerontol. 2015 68 59 65 10.1016/j.exger.2014.09.015 25262846
    [Google Scholar]
  134. Barbagallo M. Veronese N. Dominguez L.J. Magnesium in aging, health and diseases. Nutrients 2021 13 2 463 10.3390/nu13020463 33573164
    [Google Scholar]
  135. Mathew A.A. Panonnummal R. ‘Magnesium’-the master cation-as a drug—possibilities and evidences. Biometals 2021 34 5 955 986 10.1007/s10534‑021‑00328‑7 34213669
    [Google Scholar]
  136. Bjørklund G. Shanaida M. Lysiuk R. Antonyak H. Klishch I. Shanaida V. Peana M. Selenium: An antioxidant with a critical role in anti-aging. Molecules 2022 27 19 6613 10.3390/molecules27196613 36235150
    [Google Scholar]
  137. Kim J.E. Lee J. Kim H. Kim J. Cho Y. Effect of vitamin C, silicon and iron on collagen synthesis and break-down enzyme expression in the human dermal fibroblast cell (HS27). Kor. J. Nutrit. 2009 42 6 505 10.4163/kjn.2009.42.6.505
    [Google Scholar]
  138. Araújo L.A.D. Addor F. Campos P.M.B.G.M. Use of silicon for skin and hair care: an approach of chemical forms available and efficacy. An. Bras. Dermatol. 2016 91 3 331 335 10.1590/abd1806‑4841.20163986 27438201
    [Google Scholar]
  139. Gupta M. Mahajan V.K. Mehta K.S. Chauhan P.S. Zinc therapy in dermatology: A review. Dermatol. Res. Pract. 2014 2014 1 11 10.1155/2014/709152 25120566
    [Google Scholar]
  140. Das L. Bhaumik E. Raychaudhuri U. Chakraborty R. Role of nutraceuticals in human health. J. Food Sci. Technol. 2012 49 2 173 183 10.1007/s13197‑011‑0269‑4 23572839
    [Google Scholar]
  141. Kocaadam B. Şanlier N. Curcumin, an active component of turmeric ( Curcuma longa ), and its effects on health. Crit. Rev. Food Sci. Nutr. 2017 57 13 2889 2895 10.1080/10408398.2015.1077195 26528921
    [Google Scholar]
  142. Dudhe R. Dudhe A.R. Choudhari N. Katole G. Mahajan R. Pathak N. Darode A. Devnani D. A review on indian madder as an useful herb. Intern. J. New. Res. Pharm. Heal. 2023 15 1 10.61554/ijnrph.v1i1.2023.5
    [Google Scholar]
  143. Gupta R. Porte S.M. Manjishtha (Rubia Cordifolia Linn.) An ayurvedic drug: literary review. Int. J. Res. Ayurveda Pharm. 2015 6 1 90 97 10.7897/2277‑4343.06120
    [Google Scholar]
  144. Knott A Achterberg V Smuda C Mielke H Sperling G Dunckelmann K Topical treatment with coenzyme q10-containing formulas improves skin's q10 level and provides antioxidative effects. Biofactors. 2015 41 6 383 90 10.1002/biof.1239 26648450
    [Google Scholar]
  145. Cao C. Xiao Z. Tong H. Liu Y. Wu Y. Ge C. Oral intake of chicken bone collagen peptides anti-skin aging in mice by regulating collagen degradation and synthesis, inhibiting inflammation and activating lysosomes. Nutrients 2022 14 8 1622 10.3390/nu14081622 35458184
    [Google Scholar]
  146. Inoue N. Sugihara F. Wang X. Ingestion of bioactive collagen hydrolysates enhance facial skin moisture and elasticity and reduce facial ageing signs in a randomised double-blind placebo-controlled clinical study. J. Sci. Food Agric. 2016 96 12 4077 4081 10.1002/jsfa.7606 26840887
    [Google Scholar]
  147. Ohara H. Ichikawa S. Matsumoto H. Akiyama M. Fujimoto N. Kobayashi T. Tajima S. Collagen‐derived dipeptide, proline‐hydroxyproline, stimulates cell proliferation and hyaluronic acid synthesis in cultured human dermal fibroblasts. J. Dermatol. 2010 37 4 330 338 10.1111/j.1346‑8138.2010.00827.x 20507402
    [Google Scholar]
  148. Keller K.L. Fenske N.A. Uses of vitamins A, C, and E and related compounds in dermatology: A review. J. Am. Acad. Dermatol. 1998 39 4 611 625 10.1016/S0190‑9622(98)70011‑8 9777769
    [Google Scholar]
  149. Asserin J. Lati E. Shioya T. Prawitt J. The effect of oral collagen peptide supplementation on skin moisture and the dermal collagen network: evidence from an ex vivo model and randomized, placebo‐controlled clinical trials. J. Cosmet. Dermatol. 2015 14 4 291 301 10.1111/jocd.12174 26362110
    [Google Scholar]
  150. Pundir S. Garg P. Dviwedi A. Ali A. Kapoor V.K. Kapoor D. Kulshrestha S. Lal U.R. Negi P. Ethnomedicinal uses, phytochemistry and dermatological effects of Hippophae rhamnoides L.: A review. J. Ethnopharmacol. 2021 266 113434 10.1016/j.jep.2020.113434 33017636
    [Google Scholar]
  151. Lee J. Jung E. Lee J. Huh S. Kim J. Park M. So J. Ham Y. Jung K. Hyun C.G. Kim Y.S. Park D. Panax ginseng induces human Type I collagen synthesis through activation of smad signaling. J. Ethnopharmacol. 2007 109 1 29 34 10.1016/j.jep.2006.06.008 16890388
    [Google Scholar]
  152. Belwal T. Devkota H.P. Hassan H.A. Ahluwalia S. Ramadan M.F. Mocan A. Atanasov A.G. Phytopharmacology of Acerola ( Malpighia spp. ) and its potential as functional food. Trends Food Sci. Technol. 2018 74 99 106 10.1016/j.tifs.2018.01.014
    [Google Scholar]
  153. Rizzo J. Min M. Adnan S. Afzal N. Maloh J. Chambers C.J. Fam V. Sivamani R.K. Soy protein containing isoflavones improves facial signs of photoaging and skin hydration in postmenopausal women: Results of a prospective randomized double-blind controlled trial. Nutrients 2023 15 19 4113 10.3390/nu15194113 37836398
    [Google Scholar]
  154. De Luca C. Mikhal’chik E.V. Suprun M.V. Papacharalambous M. Truhanov A.I. Korkina L.G. Skin antiageing and systemic redox effects of supplementation with marine collagen peptides and plant‐derived antioxidants: A single‐blind case‐control clinical study. Oxid. Med. Cell. Longev. 2016 2016 1 4389410 10.1155/2016/4389410 26904164
    [Google Scholar]
  155. Ghatge A.S. Ghatge S.B. The effectiveness of injectable hyaluronic acid in the improvement of the facial skin quality: A systematic review. Clin. Cosmet. Investig. Dermatol. 2023 16 891 899 10.2147/CCID.S404248 37038447
    [Google Scholar]
  156. Razia S. Park H. Shin E. Shim K-S. Cho E. Kim S-Y. Effects of aloe vera flower extract and its active constituent isoorientin on skin moisturization via regulating involucrin expression: In vitro and molecular docking studies. Molecules 2021 26 9 2626 10.3390/molecules26092626
    [Google Scholar]
  157. Rastogi R. Lima G.D. Gholap A. Combination of sodium hyaluronate, Withania somnifera extract and niacinamide improves hydration and skin tone – a clinical study. Curr. Cosme. Sci. 2023 2 e280823220409 10.2174/2666779702666230828094003
    [Google Scholar]
  158. Kwatra B. Solanki A. Pal M. Jasdanwala S.S. Pathak T. Reviewing effects of rosehip, curcumin, piperine and chondroitin sulfate on collagen. Int. J. Pharm. Sci. Rev. Res. 2021 68 1 10.47583/ijpsrr.2021.v68i01.025
    [Google Scholar]
  159. Ivarsson J. Jr Pecorelli A. Lila M.A. Valacchi G. Blueberry supplementation and skin health. Antioxidants 2023 12 6 1261 10.3390/antiox12061261 37371992
    [Google Scholar]
  160. Sharma P. Dwivedee B.P. Bisht D. Dash A.K. Kumar D. The chemical constituents and diverse pharmacological importance of Tinospora cordifolia. Heliyon 2019 5 9 e02437 10.1016/j.heliyon.2019.e02437 31701036
    [Google Scholar]
  161. Chaikul P. Kanlayavattanakul M. Somkumnerd J. Lourith N. Phyllanthus emblica L. (amla) branch: A safe and effective ingredient against skin aging. J. Tradit. Complement. Med. 2021 11 5 390 399 10.1016/j.jtcme.2021.02.004 34522633
    [Google Scholar]
  162. Vaughn A.R. Branum A. Sivamani R.K. Effects of turmeric (Curcuma longa ) on skin health: A systematic review of the clinical evidence. Phytother. Res. 2016 30 8 1243 1264 10.1002/ptr.5640 27213821
    [Google Scholar]
  163. Sikandan A. Shinomiya T. Nagahara Y. Ashwagandha root extract exerts anti‑inflammatory effects in HaCaT cells by inhibiting the MAPK/NF‑κB pathways and by regulating cytokines. Int. J. Mol. Med. 2018 42 1 425 434 10.3892/ijmm.2018.3608 29620265
    [Google Scholar]
  164. Park C. Park J. Kim W.J. Kim W. Cheong H. Kim S.J. Malonic acid isolated from Pinus densiflora inhibits UVB-induced oxidative stress and inflammation in HaCaT keratinocytes. Polymers (Basel) 2021 13 5 816 10.3390/polym13050816 33799974
    [Google Scholar]
  165. Huang Z. Liu Y. Qi G. Brand D. Zheng S. Role of vitamin A in the immune system. J. Clin. Med. 2018 7 9 258 10.3390/jcm7090258 30200565
    [Google Scholar]
  166. Penniston K.L. Tanumihardjo S.A. The acute and chronic toxic effects of vitamin A. Am. J. Clin. Nutr. 2006 83 2 191 201 10.1093/ajcn/83.2.191 16469975
    [Google Scholar]
  167. Chen G. Weiskirchen S. Weiskirchen R. Vitamin A: too good to be bad? Front. Pharmacol. 2023 14 1186336 10.3389/fphar.2023.1186336 37284305
    [Google Scholar]
  168. Schaffellner S. Stadlbauer V. Sereinigg M. Mìller H. Högenauer C. Fickert P. Krumnikl J. Lackner C. Kniepeiss D. Stauber R.E. Niacin-associated acute hepatotoxicity leading to emergency liver transplantation. Am. J. Gastroenterol. 2017 112 8 1345 1346 10.1038/ajg.2017.171 28766583
    [Google Scholar]
  169. Calderon-Ospina C.A. Nava-Mesa M.O. Paez-Hurtado A.M. Update on safety profiles of vitamins B1, B6, and B12: A narrative review. Ther. Clin. Risk Manag. 2020 16 1275 1288 10.2147/TCRM.S274122 33376337
    [Google Scholar]
  170. Carr A. Maggini S. Vitamin C and immune function. Nutrients 2017 9 11 1211 10.3390/nu9111211 29099763
    [Google Scholar]
  171. Doseděl M. Jirkovský E. Macáková K. Krčmová L. Javorská L. Pourová J. Mercolini L. Remião F. Nováková L. Mladěnka P. Vitamin C—sources, physiological role, kinetics, deficiency, use, toxicity, and determination. Nutrients 2021 13 2 615 10.3390/nu13020615 33668681
    [Google Scholar]
  172. Malihi Z. Wu Z. Lawes C.M.M. Scragg R. Adverse events from large dose vitamin D supplementation taken for one year or longer. J. Steroid Biochem. Mol. Biol. 2019 188 29 37 10.1016/j.jsbmb.2018.12.002 30529281
    [Google Scholar]
  173. Wiklund RA Vitamin E supplementation and cardiovascular events in high-risk patients. N. Engl. J. Med. 2000 342 3 154 60 10.1097/00132586‑200012000‑00022 10639540
    [Google Scholar]
  174. Miller E.R. III Pastor-Barriuso R. Dalal D. Riemersma R.A. Appel L.J. Guallar E. Meta-analysis: high-dosage vitamin E supplementation may increase all-cause mortality. Ann. Intern. Med. 2005 142 1 37 46 10.7326/0003‑4819‑142‑1‑200501040‑00110 15537682
    [Google Scholar]
  175. Banach W. Nitschke K. Krajewska N. Mongiałło W. Matuszak O. Muszyński J. Skrypnik D. The association between excess body mass and disturbances in somatic mineral levels. Int. J. Mol. Sci. 2020 21 19 7306 10.3390/ijms21197306 33022938
    [Google Scholar]
  176. Tapiero H. Townsend D.M. Tew K.D. Trace elements in human physiology and pathology. copper. Biomed. Pharmacother. 2003 57 9 386 398 10.1016/S0753‑3322(03)00012‑X 14652164
    [Google Scholar]
  177. Pizarro F. Olivares M. Uauy R. Contreras P. Rebelo A. Gidi V. Acute gastrointestinal effects of graded levels of copper in drinking water. Environ. Health Perspect. 1999 107 2 117 121 10.1289/ehp.99107117 9924006
    [Google Scholar]
  178. Karim N. Copper and human health- a review. J. Bahr. Univer. Medi. Dent. Coll. 2018 8 2 117 122 10.51985/JBUMDC2018046
    [Google Scholar]
  179. Duncan A. Forrest J.A.H. Surreptitious abuse of magnesium laxatives as a cause of chronic diarrhoea. Eur. J. Gastroenterol. Hepatol. 2001 13 5 599 601 10.1097/00042737‑200105000‑00023 11396544
    [Google Scholar]
  180. Araújo C.A.L. Lorena S.B. Cavalcanti G.C.S. Leão G.L.S. Tenório G.P. Alves J.G.B. Oral magnesium supplementation for leg cramps in pregnancy—An observational controlled trial. PLoS One 2020 15 1 e0227497 10.1371/journal.pone.0227497 31923242
    [Google Scholar]
  181. MacFarquhar J.K. Broussard D.L. Melstrom P. Hutchinson R. Wolkin A. Martin C. Burk R.F. Dunn J.R. Green A.L. Hammond R. Schaffner W. Jones T.F. Acute selenium toxicity associated with a dietary supplement. Arch. Intern. Med. 2010 170 3 256 261 10.1001/archinternmed.2009.495 20142570
    [Google Scholar]
  182. Wu W.Y. Chou P.L. Yang J.C. Chien C.T. Silicon-containing water intake confers antioxidant effect, gastrointestinal protection, and gut microbiota modulation in the rodents. PLoS One 2021 16 3 e0248508 10.1371/journal.pone.0248508 33788857
    [Google Scholar]
  183. Rakhmanin Y.A. Egorova N.A. Krasovsky G.N. Mikhailova R.I. Alekseeva A.V. Silicon: Its biological impact under dietary intake and hygienic standardization of its content in drinking water. a review. Hygi. sanitat. 2019 96 5 492 498 10.18821/0016‑9900‑2017‑96‑5‑492‑498
    [Google Scholar]
  184. Plum L.M. Rink L. Haase H. The essential toxin: impact of zinc on human health. Int. J. Environ. Res. Publ. Heal. 2010 7 4 1342 1365 10.3390/ijerph7041342 20617034
    [Google Scholar]
  185. Chang C.H. Tseng P.T. Chen N.Y. Lin P.C. Lin P.Y. Chang J.P.C. Kuo F.Y. Lin J. Wu M.C. Su K.P. Safety and tolerability of prescription omega-3 fatty acids: A systematic review and meta-analysis of randomized controlled trials. Prostaglandins Leukot. Essent. Fatty Acids 2018 129 1 12 10.1016/j.plefa.2018.01.001 29482765
    [Google Scholar]
  186. Carr J.A. Role of fish oil in post - cardiotomy bleeding: a summary of the basic science and clinical trials. Ann. Thorac. Surg. 2018 105 5 1563 1567 10.1016/j.athoracsur.2018.01.041 29627068
    [Google Scholar]
  187. Detopoulou P. Papamikos V. Gastrointestinal bleeding after high intake of omega-3 fatty acids, cortisone and antibiotic therapy: A case study. Int. J. Sport Nutr. Exerc. Metab. 2014 24 3 253 257 10.1123/ijsnem.2013‑0204 24281788
    [Google Scholar]
  188. Halliwell B. Dietary polyphenols: Good, bad, or indifferent for your health? Cardiovasc. Res. 2007 73 2 341 347 10.1016/j.cardiores.2006.10.004 17141749
    [Google Scholar]
  189. Sánchez-Fidalgo S. Cárdeno A. Villegas I. Talero E. de la Lastra C.A. Dietary supplementation of resveratrol attenuates chronic colonic inflammation in mice. Eur. J. Pharmacol. 2010 633 1-3 78 84 10.1016/j.ejphar.2010.01.025 20132809
    [Google Scholar]
  190. Neves A.R. Lucio M. Lima J.L. Reis S. Resveratrol in medicinal chemistry: a critical review of its pharmacokinetics, drug-delivery, and membrane interactions. Curr. Med. Chem. 2012 19 11 1663 1681 10.2174/092986712799945085 22257059
    [Google Scholar]
  191. Mazzanti G. Di Sotto A. Vitalone A. Hepatotoxicity of green tea: an update. Arch. Toxicol. 2015 89 8 1175 1191 10.1007/s00204‑015‑1521‑x 25975988
    [Google Scholar]
  192. Lundh K. Hindsén M. Gruvberger B. Möller H. Svensson Å. Bruze M. Contact allergy to herbal teas derived from Asteraceae plants. Contact Dermat. 2006 54 4 196 201 10.1111/j.0105‑1873.2006.00709.x 16650094
    [Google Scholar]
  193. Hu Z. Yang X. Ho P.C.L. Chan S.Y. Heng P.W.S. Chan E. Duan W. Koh H.L. Zhou S. Herb-drug interactions. Drugs 2005 65 9 1239 1282 10.2165/00003495‑200565090‑00005 15916450
    [Google Scholar]
  194. Sharma D. Rashid G. Sharma L. Probiotics. 1st Ed. Boca Raton CRC Press 2024 325 343 10.1201/9781003452249‑15
    [Google Scholar]
  195. R S A. Beniwal M.K. Sengar G.S. Septicemia: As a result of erroneous parenteral administration of probiotic. Ind. J. Case Repo. 2022 72–74 72 74 10.32677/ijcr.v8i3.3323
    [Google Scholar]
  196. Kodentsova V.M. Risnik D.V. Moiseenok A.G. Algorithm for effective use of vitamin and mineral supplements. J. The Grodno State Medi. Univer. 2024 22 2 177 184 10.25298/2221‑8785‑2024‑22‑2‑177‑184
    [Google Scholar]
  197. Nasri H. Baradaran A. Shirzad H. Rafieian-Kopaei M. New concepts in nutraceuticals as alternative for pharmaceuticals. Int. J. Prev. Med. 2014 5 12 1487 1499 25709784
    [Google Scholar]
  198. Wang K. Adverse Reaction Prediction and Pharmacovigilance of Nutraceuticals. Nutraceuticals. New York Elsevier 2016 239 248 10.1016/B978‑0‑12‑802147‑7.00019‑X
    [Google Scholar]
  199. Khan S. Ibrahim M. A systematic review on hepatoprotective potential of grape and polyphenolic compounds: Molecular mechanism and future prospective. Natu. Resour. Hum. Heal. 2022 3 2 196 213 10.53365/nrfhh/156261
    [Google Scholar]
  200. Andrew R. Izzo A.A. Principles of pharmacological research of nutraceuticals. Br. J. Pharmacol. 2017 174 11 1177 1194 10.1111/bph.13779 28500635
    [Google Scholar]
  201. Helal N.A. Eassa H.A. Amer A.M. Eltokhy M.A. Edafiogho I. Nounou M.I. Nutraceuticals’ novel formulations: The good, the bad, the unknown and patents involved. Recent Pat. Drug Deliv. Formul. 2019 13 2 105 156 10.2174/1872211313666190503112040 31577201
    [Google Scholar]
  202. Gehm B.D. McAndrews J.M. Chien P.Y. Jameson J.L. Resveratrol, a polyphenolic compound found in grapes and wine, is an agonist for the estrogen receptor. Proc. Natl. Acad. Sci. USA 1997 94 25 14138 14143 10.1073/pnas.94.25.14138 9391166
    [Google Scholar]
  203. Zaborowski M.K. Długosz A. Błaszak B. Szulc J. Leis K. The role of quercetin as a plant-derived bioactive agent in preventive medicine and treatment in skin disorders. Molecules 2024 29 13 3206 10.3390/molecules29133206 38999158
    [Google Scholar]
  204. Susan CK Stephen MP Thomas DG Erythropoietic protoporphyria. Ped. Derm. 2007 14 383 10.1111/j.1525‑1470.2007.00383.x
    [Google Scholar]
/content/journals/cpd/10.2174/0113816128336661250218080928
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Nutraceutical Interventions for Mitigating Skin Ageing: Analysis of Mechanisms and Efficacy
Bentham Science Publishers ; https://doi.org/10.2174/0113816128336661250218080928
/content/journals/cpd/10.2174/0113816128336661250218080928
/content/journals/cpd/10.2174/0113816128336661250218080928
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  • Article Type:     Review Article
Keywords: nutraceuticals ; Skin ageing ; vitamins ; minerals ; skin anti-ageing

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