Current Pharmaceutical Design - Online First

Skin ageing is influenced by intrinsic factors such as genetics and hormones, as well as extrinsic factors like environmental exposure, ultraviolet (UV) radiation, and diet. These factors lead to biochemical, biological, and structural changes in the skin. Plant-derived compounds with antioxidant and anti-inflammatory properties have emerged as potential anti-ageing agents. This comprehensive review, spanning data from 1997 t Read More

Background Zuo Gui pill (ZGP) is a herbal compound formulation used to treat knee osteoarthritis (KOA), but its underlying mechanisms are still unclear. This study aimed to initially elucidate the molecular mechanisms of ZGP in treating KOA using network pharmacology and molecular docking techniques. Methods We collected information on the drug compounds and targets from TCMSP, HERB, BATMAN-TCM, and UniPr Read More

Liver cancer, particularly Hepatocellular Carcinoma (HCC), remains a significant global health challenge owing to its high incidence and position as the fourth leading cause of cancer-related mortality. HCC represents 75-85% of all liver cancer cases and ranks as the sixth most prevalent cancer globally. Several factors, including late-stage diagnosis, limited treatment effectiveness, resistance to conventional therapies, and adver Read More

Background Type 2 Diabetes Mellitus (T2DM) is a chronic metabolic disease primarily characterized by insufficient insulin secretion or reduced insulin sensitivity in the body's cells, leading to persistently high blood glucose levels. Ganoderma lucidum triterpenoids, as important secondary metabolites of Ganoderma lucidum, have shown preliminary potential efficacy in the treatment of T2DM according to existing research. Read More

Aim Random use of natural herbal products affects the treatment of diseases. In this review, the limitations that may be encountered in using natural substances of plant origin and the studies on using these substances in treating cancer, cognitive disorders, heart diseases, diabetes, and microbial diseases are examined and summarized. Background People worldwide use herbal products derived from natural plants to sol Read More

Nanoemulsions have gained popularity as drug delivery vehicles owing to the enhanced solubility of insoluble drugs, the augmented stability of photo- and thermosensitive substances, and the facilitation of transdermal permeation of efficacy substances. As the cell surfaces of the skin, cornea, gastrointestinal mucosa, and other cells in living organisms carry negative charges, cationic nanoemulsions (CNE) mainly promo Read More

Chronic Kidney Disease (CKD) affects about 37 million Americans. Approximately 20% of patients with high blood pressure and 33% of patients with diabetes have kidney disease. CKD is most common among people aged 65 or older and is slightly more common in women. It substantially impacts certain ethnic groups more than others and is associated with a huge financial burden. End-Stage Kidney Disease (ESKD) is trea Read More

The field of cancer therapy has witnessed significant strides with the emergence of innovative drug delivery systems and one such promising avenue is solid lipid-based nanoparticle (SLN) technology. This abstract provides a complete overview of current advances in developing SLNs for effective cancer treatment solid lipid nanoparticles (NPs) represent a novel drug delivery platform characterized by their unique compos Read More

Introduction Anemia is one of the complications of chronic kidney disease (CKD), and its incidence gradually increases as the disease progresses. A major cause of such anemia is the severe erythropoietin deficiency in CKD. Therefore, improvement in red blood cell production is a choice of treatment. Erythropoiesis-stimulating agents (ESAs) have been used for the therapy of anemia induced in CKD. Roxadustat is a novel dr Read More

Thrombomodulin (TM) is a single-chain transmembrane glycoprotein with anticoagulant effects. TM has two forms: membrane type existing on the cell surface and blood type free in plasma and urine. TM functions as an anticoagulant cofactor for thrombin activation of protein C on the surface of vascular endothelial cells. Due to the excellent anti-coagulant effects in modulating the coagulation and fibrinolytic system, the recom Read More