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- Volume 23, Issue 41, 2017
Current Pharmaceutical Design - Volume 23, Issue 41, 2017
Volume 23, Issue 41, 2017
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New Strategies for the Prevention and Treatment of Systemic and Local Bone Loss; from Pathophysiology to Clinical Application
Bone loss is the result of a negative unbalance between bone formation ad bone resorption. In the last years, the studies on the Wnt canonical pathway have highlighted its crucial role in bone balance through its influence on the activity and maturation of the osteoblast line and in the Receptor Activator of Nuclear Factor Κ B (RANK) - RANK ligand (RANKL)/Osteoprotegerin (OPG) system. These mechanisms are involved Read More
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Prospect of Combination and Sequential Therapies for Postmenopausal Osteoporosis
More LessBackground: Osteoporosis is a systemic bone disease, which is associated with the osteoporotic fracture. Along with prolonged life expectancy, the fracture risk increases dramatically with age. So far, it is usually the first choice to using antiresorptive agents. However, current clinical therapeutic treatments are not enough to inhibit the long-term bone loss and the rising risk of bone fractures. Recently, combination and sequential Read More
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Bone-Muscle Crosstalk: Unraveling New Therapeutic Targets for Osteoporosis
Osteoporosis is a condition featured by bone mass loss and bone tissue microarchitectural alterations due to impaired tissue homeostasis favoring excessive bone resorption versus deposition. The trigger of such an impairment and the downstream molecular pathways involved are yet to be clarified. The natural course of osteoporosis is particularly worrisome because, through a “silent” progression, it enhances bone fragility, Read More
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New Strategies for the Prevention and Treatment of Bone Loss - From Mechanical Loading Point of View
Authors: Ce Shi, Bai Yang and Hongchen SunIn contemporary society, a large number of adults experience more or less decrease in bone mass or bone density. It is known that bone, in response to mechanical loading, undergoes continuous remodeling throughout life, which helps in the growth and maintenance of the skeleton. Since mechanical loading acts as an important stimulus for bone growth and maintenance, it can be used as a strategy to prevent and t Read More
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‘Osteoimmunology’ Offers New Perspectives for the Treatment of Pathological Bone Loss
Authors: Hongrui Liu, Tingting Luo, Jiali Tan, Minqi Li and Jie GuoNew evidence of the interactions between the immune system and bone has accumulated in bone diseases, including osteoporosis, periodontitis and rheumatoid arthritis. A marked imbalance between bone resorption and formation is central to the onset of pathological bone loss. Osteoimmunology has revealed that the immune system, including T cells, B cells and inflammatory cytokines, is a key regulator of both Read More
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Current and Emerging Strategies in Osteoporosis Management
Authors: Stefka Ivanova and Liliya VasilevaThe abnormal loss of bone tissue is defined as osteoporosis. Increased risk of fractures, low bone mineral density (BMD) and loss of the structural and biomechanical properties of the bone tissue characterize this pathological condition. Physiologically bone undergoes a continuous remodeling process involving balance between the activity of osteoblast and osteoclast. Disruption in this balanced condition increases the risk of os Read More
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Application of Bone Marrow Stem Cell Based Therapy in Bone Loss Diseases
By Nan XiaoHematopoietic bone marrow stem cell transplantation has been regularly used in clinical practice for over 40 years. Further research indicates that bone marrow stromal cells are also stem cells that are capable of self-renewal, proliferation and differentiation. With appropriate induction, the bone marrow stromal cells can differentiate into bone, cartilage, tendon, adipose tissue and fibrous tissue, which would potentially be ap Read More
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Pharmacological Treatment of Bone Loss
More LessBone loss is common in clinical practice, such as health assessment of postmenopausal women, treatment of tumor metastasis, side-effects of glucocorticoids, and skeletal manifestations of inflammatory diseases. The imbalance of remodeling between bone resorption and bone formation, the pathophysiological basis of bone loss, increases bone fragility. The treatment of bone loss is mainly carried out from the treatment o Read More
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Pivotal Roles of Interleukin-17 as the Epicenter of Bone Loss Diseases
Authors: Chongshan Liao, Chengfei Zhang and Yanqi YangBone remodelling is a strictly regulated dynamic process between bone resorption and bone formation. Many factors are involved in the process and affect the dynamic balance. Inflammation-mediated bone loss is a major feature of various bone diseases, including periodontitis, rheumatoid arthritis (RA) and spondyloarthritis (SpA). Interleukin-17 (IL-17) plays an important role in inflammatory bone disease and could be an att Read More
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Antidiabetic Drugs and the Kidney
Authors: Vasilis Tsimihodimos, Nikolaos Karanatsis, Eleftheria Tzavela and Moses ElisafObjective: Nephropathy is among the most common and most devastating complications of diabetes mellitus. Recent data suggest that there is a multifaceted interaction between the kidney and antidiabetic drugs. Thus, the deterioration of renal function may result in important changes in the pharmacokinetic and pharmacodynamic properties of glucose-lowering compounds. Additionally, drugs that exert their antidiabetic prop Read More
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Anthocyanins: Multi-Target Agents for Prevention and Therapy of Chronic Diseases
Authors: Swathi Putta, Nagendra S. Yarla, Ilaria Peluso, Dinesh K. Tiwari, Gorla V. Reddy, Priyanka V. Giri, Naresh Kumar, Ramarao Malla, Vijaya Rachel, P. V. Bramhachari, Rama S. Reddy D, Ramesh Bade, Mastan Mannarapu, George E. Barreto, Da-Yong Lu, Vadim V. Tarasov, Vladimir N. Chubarev, Frederico F. Ribeiro, Luciana Scotti, Marcus T. Scotti, M.A. Kamal, Ghulam Md Ashraf, Gjumrakch Aliev, George Perry, Satyajit D. Sarker, Chinthalapally V. Rao and Anupam BishayeeAnthocyanins, a flavonoid class of polyphenols, are water soluble dark colored natural pigments found in fruits and vegetables. Owing to their wide distribution in plant materials, dietary consumption of anthocyanins is high compared to other flavonoids. Anthocyanins, due to their multifaceted medicinal properties are the active components in many herbal folk medicines. As in vitro and in vivo results, animal models, and clinical Read More
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Modulation of Inflammatory Response to Implanted Biomaterials Using Natural Compounds
Authors: Maria Yanez, James Blanchette and Ehsan JabbarzadehTissue engineering offers a promising strategy to restore injuries resulting from trauma, infection, tumor resection, or other diseases. In spite of significant progress, the field faces a significant bottleneck; the critical need to understand and exploit the interdependencies of tissue healing, angiogenesis, and inflammation. Inherently, the balance of these interacting processes is affected by a number of injury site conditions t Read More
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Synthesis and Characterization of a New Benzoindole Derivative with Apoptotic Activity Against Colon Cancer Cells
Background: Colorectal cancer is the third most common form of cancer in both men and women around the world. The chemistry and biological study of heterocyclic compounds have been an interesting area for a long time in pharmaceutical and medicinal chemistry. Methods: A new synthetic compound, 2-(1,1-dimethyl-1H-benzo[e]indol-2-yl)-3-((2-hydroxyphenyl)amino) acrylaldehyde, abbreviated as DBID, was prepa Read More
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Volumes & issues
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Volume 31 (2025)
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Volume 30 (2024)
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Volume 29 (2023)
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Volume 28 (2022)
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Volume 27 (2021)
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Volume 26 (2020)
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Volume 25 (2019)
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Volume 24 (2018)
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Volume 23 (2017)
- Issue 46
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- Issue 1
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Volume 22 (2016)
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Volume 21 (2015)
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Volume 20 (2014)
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Volume 19 (2013)
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Volume 18 (2012)
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Volume 17 (2011)
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Volume 16 (2010)
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Volume 15 (2009)
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Volume 14 (2008)
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Volume 13 (2007)
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Volume 12 (2006)
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Volume 11 (2005)
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Volume 10 (2004)
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Volume 9 (2003)
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Volume 8 (2002)
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Volume 7 (2001)
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Volume 6 (2000)
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