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- Volume 23, Issue 2, 2017
Current Pharmaceutical Design - Volume 23, Issue 2, 2017
Volume 23, Issue 2, 2017
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Separation of Biologically Active Compounds by Membrane Operations
Authors: Xiaoying Zhu and Renbi BaiBackground: Bioactive compounds from various natural sources have been attracting more and more attention, owing to their broad diversity of functionalities and availabilities. However, many of the bioactive compounds often exist at an extremely low concentration in a mixture so that massive harvesting is needed to obtain sufficient amounts for their practical usage. Thus, effective fractionation or separation technolog Read More
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Concentration and Fractionation of Polyphenols by Membrane Operations
Background: This review aims to present the relevant background information and current research status in concentration of polyphenols using membrane technologies. The potential implementation of membrane separation to bioactive compounds like soluble phenolics from aqueous and organic solvent solutions is gaining increasing interest in the recent years. This review does not pretend to cover the abundant published Read More
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Membrane-Based Technologies in the Pharmaceutical Industry and Continuous Production of Polymer-Coated Crystals/Particles
Authors: Dengyue Chen, Kamalesh K. Sirkar, Chi Jin, Dhananjay Singh and Robert PfefferBackground: Membrane technologies are of increasing importance in a variety of separation and purification applications involving liquid phases and gaseous mixtures. Although the most widely used applications at this time are in water treatment including desalination, there are many applications in chemical, food, healthcare, paper and petrochemical industries. This brief review is concerned with existing and emergin Read More
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Membrane Bioreactors for Pharmaceutical Applications: Optically Pure Enantiomers Production
Authors: Emma Piacentini, Rosalinda Mazzei and Lidietta GiornoIn biological systems, recognition at molecular level is governed by chiral interactions. Therefore, optical isomers have very different effect in natural systems. For example, one can have beneficial effect while the other can be very harmful. For these reasons, chiral drugs nowadays are mainly admitted in the optically pure form. Given these requirements, it is clear why demand for chiral drugs has grown dramatically an Read More
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Polymeric Nanomaterials as Nanomembrane Entities for Biomolecule and Drug Delivery
Authors: Airama Albisa, Laura Espanol, Martin Prieto and Victor SebastianBackground: Bio-nanomaterials assembled into nanomembrane entities are actively studied to circumvent the uncontrollable list of shortcomings of conventional delivery systems: low water solubility, unfavorable stability, short circulation time in plasma, rapid clearance from the human body, poor bioavailability, non-specific toxicity against normal tissue and cells, low cellular uptake and susceptibility to enzyme degradation. Ba Read More
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Molecularly Engineered Polymer-Based Systems in Drug Delivery and Regenerative Medicine
Authors: Susanna Piluso, Al Halifa Soultan and Jennifer PattersonBackground: Polymer-based systems are attractive in drug delivery and regenerative medicine due to the possibility of tailoring their properties and functions to a specific application. Methods: The present review provides several examples of molecularly engineered polymer systems, including stimuli responsive polymers and supramolecular polymers. Results: The advent of controlled polymerization techniques has enabled the Read More
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Stimuli-Responsive Capsule Membranes for Controlled Release in Pharmaceutical Applications
Authors: Zhuang Liu, Xiao-Jie Ju, Wei Wang, Rui Xie, Lu Jiang, Qianming Chen, Yan-Qiong Zhang, Jiang-Feng Wu and Liang-Yin ChuBackground: In conventional drug delivery, the drug concentration in the blood raises once the drug taken, and then peaks and declines. Since each drug has a level above which it is toxic and another level below which it is ineffective, the drug concentration in a patient at a particular time depends on compliance with the prescribed routine. Methods: To achieve more effective efficacy and fewer side effects of drugs, the dru Read More
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Pharmaceutical Particles Design by Membrane Emulsification: Preparation Methods and Applications in Drug Delivery
Authors: Emma Piacentini, Marijana Dragosavac and Lidietta GiornoNowadays, the rational design of particles is an important issue in the development of pharmaceutical medicaments. Advances in manufacturing methods are required to design new pharmaceutical particles with target properties in terms of particle size, particle size distribution, structure and functional activity. Membrane emulsification is emerging as a promising tool for the production of emulsions and solidified particles with Read More
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Biohybrid Membrane Systems and Bioreactors as Tools for In Vitro Drug Testing
Authors: Simona Salerno and Loredana De BartoloIn drug development, in vitro human model systems are absolutely essential prior to the clinical trials, considering the increasing number of chemical compounds in need of testing, and, keeping in mind that animals cannot predict all the adverse human health effects and reactions, due to the species-specific differences in metabolic pathways. The liver plays a central role in the clearance and biotransformation of chemi Read More
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Estradiol Uptake in a Combined Magnetic Ion Exchange - Ultrafiltration (MIEX-UF) Process During Water Treatment
Authors: Alessandra Imbrogno, Jennifer Biscarat and Andrea Iris SchaferBackground: Estrogens and their synthetic analogues are widely used as pharmaceuticals. Upon oral administration these drugs are eventually excreted via urine. The persistence of these pharmaceuticals and inefficient removal by water treatment lead to accumulation in surface water and effluents with negative effects for aquatic life and human health. Methods: In this study, the uptake of estradiol by a combined magnetic Read More
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Volumes & issues
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Volume 31 (2025)
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Volume 30 (2024)
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Volume 29 (2023)
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Volume 28 (2022)
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Volume 27 (2021)
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Volume 26 (2020)
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Volume 25 (2019)
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Volume 24 (2018)
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Volume 23 (2017)
- Issue 46
- Issue 45
- Issue 44
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- Issue 12
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- Issue 2
- Issue 1
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Volume 22 (2016)
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Volume 21 (2015)
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Volume 20 (2014)
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Volume 19 (2013)
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Volume 18 (2012)
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Volume 17 (2011)
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Volume 16 (2010)
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Volume 15 (2009)
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Volume 14 (2008)
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Volume 13 (2007)
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Volume 12 (2006)
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Volume 11 (2005)
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Volume 10 (2004)
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Volume 9 (2003)
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Volume 8 (2002)
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Volume 7 (2001)
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Volume 6 (2000)
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