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- Volume 23, Issue 20, 2017
Current Pharmaceutical Design - Volume 23, Issue 20, 2017
Volume 23, Issue 20, 2017
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Magnetic Nanoparticles: New Perspectives in Drug Delivery
Authors: Joanna Wong, Jeremy Prout and Alexander SeifalianBackground: The study of magnetic nanoparticles (MNPs) for drug delivery has recently seen a surge of interest even though the first studies were conducted as early as in the seventies. Despite this, there are still gaps in the knowledge of the field, implicating the complexities in designing the ideal MNP for drug delivery. The large surface area of MNPs and the ability to manipulate with an externally applied magnetic field rende Read More
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Targeted Drug Delivery Based on Gold Nanoparticle Derivatives
Drug delivery systems are effective and attractive methods which allow therapeutic substances to be introduced into the body more effectively and safe by having tunable delivery rate and release target site. Gold nanoparticles (AuNPs) have a myriad of favorable physical, chemical, optical, thermal and biological properties that make them highly suitable candidates as non-toxic carriers for drug and gene delivery. The surfac Read More
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Calcium Phosphate Nanoparticles Cytocompatibility Versus Cytotoxicity: A Serendipitous Paradox
Authors: Milad P. Masouleh, Vahid Hosseini, Masoud Pourhaghgouy and Martin K. BakhtDue to efficacious characteristics of calcium phosphate nanoparticles (CPNs), they have numerously been employed in nanomedicine, particularly as carrier for therapeutic and diagnostic agents, and also in tissue engineering. Although calcium phosphate minerals are noted for their cytocompatibility, there are outstanding findings from various studies that question whether they are still compatible with cells in nanosc Read More
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Surface Engineered Dendrimers in siRNA Delivery and Gene Silencing
Authors: Vishakha Tambe, Shreya Thakkar, Nidhi Raval, Dilip Sharma, Kiran Kalia and Rakesh K. TekadeBackground: Therapeutic efficacy of dreadful diseases like cancer, HIV (Human Immunodeficiency Virus) can be enhanced by delivering molecules which regulate function at gene level rather than at receptor level. Silencing RNA is one such approach recently used to silence target gene expressed diseases; and thereby reduce target protein levels. Many of the non-viral vectors are proved to act as carriers for silencing R Read More
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The Potential Roles of Radionanomedicine and Radioexosomics in Prostate Cancer Research and Treatment
Authors: Martin K. Bakht, So W. Oh, Do W. Hwang, Yun-Sang Lee, Hyewon Youn, Lisa A. Porter, Gi J. Cheon, Cheol Kwak, Dong S. Lee and Keon W. KangThe artificial nanostructures such as nanoparticles and natural nanostructures such as secreted nanosized extracellular vesicles known as exosomes are promising tools for the realization of personalized medicine. Radionanomedicine is a recently coined term for the simultaneous application of either radiation technology or nuclear medicine with nanomedicine. In addition, radioexosomics is our suggested term for Read More
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Engineered Muscle Tissues for Disease Modeling and Drug Screening Applications
Authors: Mohammad H. Mohammadi, Raquel Obregón, Samad Ahadian, Javier Ramón-Azcón and Milica RadisicAnimal models have been the main resources for drug discovery and prediction of drugs’ pharmacokinetic responses in the body. However, noticeable drawbacks associated with animal models include high cost, low reproducibility, low physiological similarity to humans, and ethical problems. Engineered tissue models have recently emerged as an alternative or substitute for animal models in drug discovery and testi Read More
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A Comprehensive Review of mTOR-Inhibiting Pharmacotherapy for the Treatment of Non-Infectious Uveitis
Authors: Joshua Blair, Robert Barry, David J. Moore and Alastair K. DennistonBackground: Non-infectious uveitis is a sight-threatening inflammatory disease that often necessitates prolonged use of high-dose corticosteroids, resulting in significant systemic side effects. There is a need for efficacious steroid-sparing immunomodulatory therapy for these patients, and the mTOR inhibitors (sirolimus and everolimus) may be contenders for this role. Methods: A comprehensive review of preclinical and clinical Read More
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Chemical Properties of Caffeic and Ferulic Acids in Biological System: Implications in Cancer Therapy. A Review
The antioxidant properties of caffeic and ferulic acids in biological systems have been extensively demonstrated. As antioxidants, these compounds prevent the production of reactive oxygen species (ROS), which cause cell lesions that are associated with the development of several diseases, including cancer. Recent findings suggest that the chemoprotective action of these phenolic acids occurs through the following mechani Read More
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Are Markers of Cardiac Dysfunction Useful in the Assessment of Cardiovascular Risk in Dialysis Patients?
Authors: Beata Franczyk, Anna Gluba-Brzózka, Piotr Bartnicki, Maciej Banach and Jacek RyszBackground: Cardiovascular morbidity and mortality of dialysis patients are major problems in this group of patients. Methods: The purpose of this study was also to evaluate whether any of the studied markers are better than troponin in early detection of the occurrence of ventricular arrhythmias and prolongation of QT interval. This study included 45 patients undergoing hemodialysis. ECG Holter and echocardiographi Read More
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Long-Circulating Liposomal Delivery System Targeting at PDGFR-β Enhances the Therapeutic Effect of IFN-α on Hepatic Fibrosis
Authors: Qinghua Li, Qi Yu, Jing Ju, Tiangeng You, Zhiqiang Yan, Xiangli Nan, Jie Zhong and Jing E. ZhouBackground: In this study, we developed a drug of IFN-α combined with pPB-SSLs, which specifically target at platelet-derived growth factor receptor-β (PDGFR-β). Aim: The aim of this study is to improve the limitations of IFN-α including insufficient drug concentration for the target cells and side-effects causing serious concerns in treatment of hepatic fibrosis. Methods: We constructed the targeted stable liposomes (SSLs Read More
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Volumes & issues
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Volume 31 (2025)
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Volume 30 (2024)
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Volume 29 (2023)
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Volume 28 (2022)
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Volume 27 (2021)
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Volume 26 (2020)
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Volume 25 (2019)
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Volume 24 (2018)
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Volume 23 (2017)
- Issue 46
- Issue 45
- Issue 44
- Issue 43
- Issue 42
- Issue 41
- Issue 40
- Issue 39
- Issue 38
- Issue 37
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- Issue 35
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- Issue 32
- Issue 31
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- Issue 29
- Issue 28
- Issue 27
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- Issue 24
- Issue 23
- Issue 22
- Issue 21
- Issue 20
- Issue 19
- Issue 18
- Issue 17
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- Issue 12
- Issue 11
- Issue 10
- Issue 9
- Issue 8
- Issue 7
- Issue 6
- Issue 5
- Issue 4
- Issue 3
- Issue 2
- Issue 1
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Volume 22 (2016)
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Volume 21 (2015)
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Volume 20 (2014)
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Volume 19 (2013)
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Volume 18 (2012)
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Volume 17 (2011)
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Volume 16 (2010)
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Volume 15 (2009)
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Volume 14 (2008)
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Volume 13 (2007)
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Volume 12 (2006)
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Volume 11 (2005)
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Volume 10 (2004)
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Volume 9 (2003)
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Volume 8 (2002)
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Volume 7 (2001)
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Volume 6 (2000)
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