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- Volume 23, Issue 32, 2017
Current Pharmaceutical Design - Volume 23, Issue 32, 2017
Volume 23, Issue 32, 2017
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Tumor Reversion: Mesenchymal-Epithelial Transition as a Critical Step in Managing the Tumor-Microenvironment Cross-Talk
Authors: Mariano Bizzarri, Alessandra Cucina and Sara ProiettiTumour reversion represents a promising field of investigation. The occurrence of cancer reversion both in vitro and in vivo has been ascertained by an increasing number of reports. The reverting process may be triggered in a wide range of different cancer types by both molecular and physical cues. This process encompasses mandatorily a change in the cell-stroma interactions, leading to profound modification in tissu Read More
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Bioinformatics Approaches to Profile the Tumor Microenvironment for Immunotherapeutic Discovery
In the microenvironment of a malignancy, tumor cells do not exist in isolation, but rather in a diverse ecosystem consisting not only of heterogeneous tumor-cell clones, but also normal cell types such as fibroblasts, vasculature, and an extensive pool of immune cells at numerous possible stages of activation and differentiation. This results in a complex interplay of diverse cellular signaling systems, where the immu Read More
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Current Methods of the Circulating Tumor Cells (CTC) Analysis: A Brief Overview
Authors: Natalia Dementeva, Daria Kokova and Oleg A. MayborodaThis mini review provides a short overview of the main methods of the selection and analysis of the circulating tumor cells. We briefly focus on the evolution of the technical approaches used in the CTCs analysis from early description of the most discussed contemporary workflows such as Cellsearch and CTC-iChip. In addition, we discuss more “unconventional” approaches such as mass spectrometry and NMR based metho Read More
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Micro-RNA Profiling as a Predictor of Clinical Outcomes for Head and Neck Cancer Patients
Head and neck cancer is one of the leading malignancies worldwide. Due to the lack of symptoms in the early stage of the disease, about two thirds of patients present with locally advanced disease at the time of diagnosis. Even with significantly improved survival rates over the past two decades due to advanced imaging and treatment modalities, locoregional recurrence rates in patients with advanced disease ranges from 16% t Read More
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Recent Advances in the Function of the 67 kDa Laminin Receptor and its Targeting for Personalized Therapy in Cancer
Authors: Ada Pesapane, Pia Ragno, Carmine Selleri and Nunzia MontuoriThe 67 kDa high affinity laminin receptor (67LR) is a non-integrin cell surface receptor for laminin, the major component of basement membranes. Interactions between 67LR and laminin play a major role in mediating cell adhesion, migration, proliferation and survival. 67LR derives from homo- or hetero-dimerization of a 37 kDa cytosolic precursor (37LRP), most probably by fatty acid acylation. Interestingly, 37LRP, also called p Read More
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DNA Base Excision Repair: The Achilles' Heel of Tumour Cells and their Microenvironment?
Authors: Mattia Poletto, Arnaud J. Legrand and Grigory L. DianovOur current understanding of cancer suggests that every tumour has individual features. Approaches to cancer treatment require thorough comprehension of the mechanisms triggering genomic instability and protecting cancer cells from therapeutic treatments. Base excision repair (BER) is a frontline DNA repair system that is responsible for maintaining genome integrity. The BER pathway prevents the occurrence of Read More
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Identification of Antineoplastic Targets with Systems Approaches, Using Resveratrol as an In-Depth Case Study
The identification and validation of novel drug–target combinations are key steps in the drug discovery processes. Cancer is a complex disease that involves several genetic and environmental factors. High-throughput omics technologies are now widely available, however the integration of multi-omics data to identify viable anticancer drug-target combinations, that allow for a better clinical outcome when considering the efficacy- Read More
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Molecular Tests for the Choice of Cancer Therapy
Authors: Anna P. Sokolenko and Evgeny N. ImyanitovThere are over a dozen of approved cancer drugs, whose administration is tailored to predictive laboratory tests. The examples include estrogen and progesterone receptor status determination for the use of endocrine therapy, HER2 assessment for the administration of HER2-targeting agents, EGFR and ALK gene testing for lung cancer treatment, BRAF analysis in melanoma, etc. While first predictive tests relied on relat Read More
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Role of the Immune Component of Tumor Microenvironment in the Efficiency of Cancer Treatment: Perspectives for the Personalized Therapy
Despite significant progress in cancer diagnostics and development of novel therapeutic regimens, successful treatment of advanced forms of cancer is still a challenge and may require personalized therapeutic approaches. In this review, we analyzed major mechanisms responsible for tumor cells chemoresistance and emphasized that intratumor heterogeneity is a critical factor that limits efficiency of cancer treatment. Read More
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Ion Channel and Neurotransmitter Modulators as Electroceutical Approaches to the Control of Cancer
Authors: Jack Tuszynski, Tatiana M. Tilli and Michael LevinThe activities of individual cells must be tightly coordinated in order to build and maintain complex 3- dimensional body structures during embryogenesis and regeneration. Thus, one way to view cancer is within systems biology as a network disorder affecting the ability of cells to properly interact with a morphodynamic field of instructive signals that keeps proliferation and migration orchestrated toward the anato Read More
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Epigenetics of Virus-Induced Tumors: Perspectives for Therapeutic Targeting
More LessAbout 15–20% of human cancers worldwide have viral etiology. Seven human DNA and RNA viruses are accepted to be oncogenic viruses or oncoviruses and contribute to the development of various cancer types. Human oncoviruses have developed multiple molecular mechanisms to interfere with specific cellular pathways to promote viral replication and viral life cycle maintenance in the host. Despite the diversity of Read More
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Always Look On the Bright Side: Anti-Tumor Functions of Neutrophils
Authors: Sandra Vols, Ronit V. Sionov and Zvi GranotNeutrophils are the most abundant population of white blood cells in the human circulation playing a critical role in inflammation and in host defense against microbial infections. In recent years there has been growing interest in understanding the role the tumor microenvironment plays in tumor growth and progression. In this context, the role neutrophils play has been a matter of debate as neutrophils were shown to po Read More
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Targeting the Tumor Microenvironment by Intervention in Interleukin-1 Biology
Authors: Elena Voronov and Ron N. ApteThe importance of anti-tumor immunity in the outcome of cancer is now unequivocally established and recent achivements in the field have stimulated the development of new immunotherapeutical approaches. In invasive tumors, widespread inflammation promotes invasiveness and concomitantly also inhibits anti-tumor immune responses. We suggest that efficient tumor treatment should target both the malignant c Read More
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Application of Alphaviral Vectors for Immunomodulation in Cancer Therapy
Authors: Anna Zajakina, Karina Spunde and Kenneth LundstromBackground: The lack of specific and efficient cancer therapies has influenced the development of novel approaches, such as immunotherapy, which from its original application of immunogenic protein delivery has developed into the use of more sophisticated recombinant gene delivery methods to achieve better safety and efficacy profiles. This approach involves viral and non-viral delivery systems. Methods: Expression Read More
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Volumes & issues
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Volume 31 (2025)
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Volume 30 (2024)
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Volume 29 (2023)
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Volume 28 (2022)
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Volume 27 (2021)
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Volume 26 (2020)
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Volume 25 (2019)
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Volume 24 (2018)
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Volume 23 (2017)
- Issue 46
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Volume 22 (2016)
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Volume 21 (2015)
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Volume 20 (2014)
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Volume 19 (2013)
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Volume 18 (2012)
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Volume 17 (2011)
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Volume 16 (2010)
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Volume 15 (2009)
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Volume 14 (2008)
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Volume 13 (2007)
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Volume 12 (2006)
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Volume 11 (2005)
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Volume 10 (2004)
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Volume 9 (2003)
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Volume 8 (2002)
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Volume 7 (2001)
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Volume 6 (2000)
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