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- Volume 23, Issue 24, 2017
Current Pharmaceutical Design - Volume 23, Issue 24, 2017
Volume 23, Issue 24, 2017
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Tissue Engineered Skin and Wound Healing: Current Strategies and Future Directions
Authors: Nandana Bhardwaj, Dimple Chouhan and Biman B. MandalThe global volume of skin damage or injuries has major healthcare implications and, accounts for about half of the world's annual expenditure in the healthcare sector. In the last two decades, tissue-engineered skin constructs have shown great promise in the treatment of various skin-related disorders such as deep burns and wounds. The treatment methods for skin replacement and repair have evolved from utilization of auto Read More
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From Tendon Injury to Collagen-based Tendon Regeneration: Overview and Recent Advances
Authors: Clement Rieu, Lise Picaut, Gervaise Mosser and Lea TrichetTendon injury is a clinical, societal and economical issue. Moreover, tendon repair represents an important clinical challenge, partly due to the mechanical constraints that occur at the junctions with muscle and bone. Several strategies have been developed for tendon repair. In this review, we first assess the importance of tendon injuries from different sites and their causes. After a short overview of tendon three-dimension Read More
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Biomorphic Ceramics for Drug Delivery in Bone Tissue Regeneration
Authors: Patricia Diaz-Rodriguez and Mariana LandinIncorporating therapeutic molecules into biomorphic ceramics for in situ drug release can be used to generate novel systems for tissue regeneration. These systems couple the complex hierarchical porous structures of biomorphic ceramics with the therapeutic activity of drugs. There are a large number of natural precursors available to be used as templates to obtain biomorphic silicon carbide ceramics. Additio Read More
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Nanotechnology: A Promising Tool Towards Wound Healing
Nanotechnology is an exciting emerging field with multiple applications in skin regeneration. Nanofibers have gained special attention in skin regeneration based on their structural similarity to the extracellular matrix. A wide variety of polymeric nanofibers with distinct properties have been developed and tested as scaffolds for skin regeneration. Besides providing support for tissue repair, nanofibrous materials can act Read More
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Controlled Delivery of Bioactive Molecules for the Treatment of Chronic Wounds
Authors: J. Anjana, V. K. Rajan, Raja Biswas and R. JayakumarA cut or break on the surface of the skin is usually referred to as a wound. Any wound has a potential to heal by itself through a complex cascade of events. However, some wounds show delayed healing due to their underlying physiology and are referred to as chronic wounds like diabetic ulcers, venous ulcers, pressure ulcers and chronic infected ulcers. Extensive care has to be taken for the management of chronic wound Read More
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The Chemo-Biological Outreach of Nano-Biomaterials: Implications for Tissue Engineering and Regenerative Medicine
Authors: Pradeep Kumar, Yahya E. Choonara, Riaz A. Khan and Viness PillayNanobiomaterials can be defined as materials interacting with and influencing the biological microenvironment at a nanointerface. Recently the basic as well as applied research related to nanobiomaterials - a conjugation of nano-, material- and life-sciences - has immensely evolved for therapeutics and related biotechnology areas. The current overview focused on the potential of nanobiomaterial-based substrates towa Read More
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Methotrexate in the Treatment of Psoriasis and Rheumatoid Arthritis: Mechanistic Insights, Current Issues and Novel Delivery Approaches
Authors: Panonnummal Rajitha, Raja Biswas, Mangalathillam Sabitha and R. JayakumarOur review is focused on the use of methotrexate in drug therapy of two autoimmune diseases, psoriasis and rheumatoid arthritis (RA). The article describes the pathogenesis of psoriasis and RA, the role of methotrexate in the treatment of these diseases with more focused review on the mechanism behind the clinical benefits of methotrexate therapy. Methotrexate due to its cytotoxic, anti-inflammatory and immune mod Read More
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Gelatin as Biomaterial for Tissue Engineering
Authors: Mari C. Echave, Laura S. Burgo, Jose L. Pedraz and Gorka OriveTissue engineering is considered one of the most important therapeutic strategies of regenerative medicine. The main objective of these new technologies is the development of substitutes made with biomaterials that are able to heal, repair or regenerate injured or diseased tissues and organs. These constructs seek to unlock the limited ability of human tissues and organs to regenerate. In this review, we highlight the co Read More
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Engineered Bone Tissue with Naturally-Derived Small Molecules
Authors: Guleid Awale, Edgar Wong, Komal Rajpura and Kevin W.-H. LoNatural products remain the best resources of drugs and drug leads. Recently, there is growing recognition that identifying new small molecules to promote bone regeneration is a laudable translational goal. In fact, new approaches for bone repair and regeneration that involve inexpensive naturally-derived compounds would have an important impact on the treatment of bone disorders and injuries. Over the past several de Read More
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Bioresponsive Injectable Hydrogels for On-demand Drug Release and Tissue Engineering
Authors: Arti Vashist, Ajeet Kaushik, Kayla Alexis, Rahul Dev Jayant, Vidya Sagar, Atul Vashist and Madhavan NairThe emergence of injectable hydrogels as biomaterials has been a revolutionary breakthrough in the field of on-demand drug delivery and tissue engineering. The promising features of these systems include their biodegradability, biocompatibility, permeability, ease of the surgical implantation, and most importantly exhibit minimally invasiveness. These hydrogels have been explored as sustained and on-demand re Read More
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3D In Vitro Models of Early Pregnancy: How to Choose the Right Scaffolding Material?
Authors: Damian Muzzio, Maria L. Foglia, Martin F. Desimone and Marek ZygmuntFollowing fertilization, the blastocyst has to complete two distinct steps to assure further development of pregnancy. After apposition it establishes a firm connection with the luminal epithelium of the endometrium (attachment) and subsequently enters the decidualizing stroma (invasion). If this step is not achieved successfully, fertility problems arise. Development of the placenta ensures an adequate supply of nutrients and gas Read More
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Gene Delivery with Organic Electronic Biomaterials
Authors: Kathryn F.A. Clancy and John G. HardyGene therapy may be capable of treating a variety of diseases, a prerequisite of which is the successful delivery of polynucleic acids (e.g., DNA, RNA) to a patient’s cells. Delivery can be achieved technologically (e.g., using electroporation), using viruses (natural gene delivery vectors) or non-viral vectors (e.g., lipids, nanoparticles, polymers). This article aims to give the reader an overview of the use of organic electronic mate Read More
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Volumes & issues
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Volume 31 (2025)
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Volume 30 (2024)
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Volume 29 (2023)
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Volume 28 (2022)
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Volume 27 (2021)
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Volume 26 (2020)
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Volume 25 (2019)
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Volume 24 (2018)
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Volume 23 (2017)
- Issue 46
- Issue 45
- Issue 44
- Issue 43
- Issue 42
- Issue 41
- Issue 40
- Issue 39
- Issue 38
- Issue 37
- Issue 36
- Issue 35
- Issue 34
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- Issue 32
- Issue 31
- Issue 30
- Issue 29
- Issue 28
- Issue 27
- Issue 26
- Issue 25
- Issue 24
- Issue 23
- Issue 22
- Issue 21
- Issue 20
- Issue 19
- Issue 18
- Issue 17
- Issue 16
- Issue 15
- Issue 14
- Issue 13
- Issue 12
- Issue 11
- Issue 10
- Issue 9
- Issue 8
- Issue 7
- Issue 6
- Issue 5
- Issue 4
- Issue 3
- Issue 2
- Issue 1
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Volume 22 (2016)
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Volume 21 (2015)
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Volume 20 (2014)
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Volume 19 (2013)
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Volume 18 (2012)
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Volume 17 (2011)
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Volume 16 (2010)
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Volume 15 (2009)
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Volume 14 (2008)
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Volume 13 (2007)
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Volume 12 (2006)
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Volume 11 (2005)
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Volume 10 (2004)
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Volume 9 (2003)
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Volume 8 (2002)
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Volume 7 (2001)
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Volume 6 (2000)
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