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- Volume 23, Issue 36, 2017
Current Pharmaceutical Design - Volume 23, Issue 36, 2017
Volume 23, Issue 36, 2017
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Overview of Forensic Toxicology, Yesterday, Today and in the Future
Authors: Heesun Chung and Sanggil ChoeBackground: The scope of forensic toxicology has been tremendously expanded over the past 50 years. From two general sections forensic toxicology can be further classified into 8-9 sections. Methods: The most outstanding improvement in forensic toxicology is the changes brought by instrumental development. The field of forensic toxicology was revolutionized by the development of immunoassay and benchtop GC-M Read More
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Good Practices in Forensic Toxicology
More LessThis manuscript provides an overview for analysts, medical and scientific investigators, and laboratory administrators, the range of factors that should be considered to implement best practice forensic toxicology. These include laboratory influence over the collection of specimens, their proper transport and chain-of-custody before arrival in the laboratory. In addition, the laboratory needs to ensure properly trained staff Read More
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Update of Standard Practices for New Method Validation in Forensic Toxicology
Authors: Sarah M.R. Wille, Wim Coucke, Thierry De Baere and Frank T. PetersInternational agreement concerning validation guidelines is important to obtain quality forensic bioanalytical research and routine applications as it all starts with the reporting of reliable analytical data. Standards for fundamental validation parameters are provided in guidelines as those from the US Food and Drug Administration (FDA), the European Medicines Agency (EMA), the German speaking Gesellschaft fur Toxikologie un Read More
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Method Development in Forensic Toxicology
Background: In the field of forensic toxicology, the quality of analytical methods is of great importance to ensure the reliability of results and to avoid unjustified legal consequences. A key to high quality analytical methods is a thorough method development. Methods: The presented article will provide an overview on the process of developing methods for forensic applications. Results: This includes the definition of the meth Read More
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Nails in Forensic Toxicology: An Update
Background: The analysis of nails as a keratinized matrix to detect drugs or illicit substances has been increasingly used in forensic and clinical toxicology as a complementary test, especially for the specific characteristics of stably accumulating substances for long periods of time. This allows a retrospective investigation of chronic drug abuse, monitoring continuous drug or pharmaceutical use, reveal in utero drug expo Read More
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Hair Analysis in Forensic Toxicology: An Updated Review with a Special Focus on Pitfalls
By Pascal KintzBackground: The detection of drugs in hair analysis has progressively emerged as a consequence of the enhanced sensitivity of analytical techniques used in forensic toxicology; a greater advantage in using this matrix with respect to classical ones (i.e. urine and blood) is an easier and non-invasive sample collection, even when the careful supervision of law enforcement officers is required to avoid the risk that the sam Read More
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Prevalence and Surveillance of Synthetic Cathinones Use by Hair Analysis: An Update Review
Authors: Jean-Claude Alvarez, Nicolas Fabresse and Islam A. LarabiNew psychoactive substances (NPS) have emerged in a threatening way in the last decades. They are sold via the internet or head shops with several names (bath salts, Research chemical, RCs, Legal Highs) and forms (pills, tablets, powder...etc.), and are labelled ambiguously to escape governmental legislation. Designer drugs belong to different chemical classes, but cathinones derivatives presented the most prevalent Read More
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LSD Detection and Interpretation in Hair
Authors: Camille Richeval, Delphine Allorge, Xavier Vanhoye and Jean-michel GaulierLysergic acid diethylamide (LSD) is a powerful hallucinogen, active at very low dosages, with, as a direct consequence, potential difficulties to be detected and quantified in a clinical or forensic context, in body fluids and even more in hair. The aim of this work is to review literature data related to hair analysis of LSD with a particular focus on the main issues encountered in LSD detection in hair. Results of LSD investigatio Read More
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Interest of Single Hair Analysis to Document Drug Exposure: Literature Review and a Case Report Involving Zuclopenthixol
The analysis of hair to detect drugs and drugs of abuse is performed in various contexts, including child protection cases, abstinence control programs, and workplace drug testing. This alternative matrix offers several advantages, such as a large detection window (months) and non-invasive collection. Segmental analysis of multiple hair strands for drugs and metabolites has been widely reported in the literature over Read More
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Mephedrone Concentrations in Cases of Clinical Intoxication
Authors: Esther Papaseit, Eulalia Olesti, Rafael de la Torre, Marta Torrens and Magi FarreBackground: Mephedrone (4-methylmethcathinone, 4-MMC), a ring-substituted synthetic cathinone derivative has become established as a permanent illicit drug in the dynamic new psychoactive substances (NPS) scene. Objective: This review summarizes current knowledge on mephedrone concentrations in biological samples from cases of acute intoxications (fatal and non-fatal), pharmacokinetics studies, wast Read More
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Pharmacology and Literature Review Based on Related Death and Non-Fatal Case Reports of the Benzofurans and Benzodifurans Designer Drugs
Authors: Bernardino Barcelo and Isabel GomilaBackground: Benzofurans and benzodifurans are two groups of psychoactive substances that had originally been synthesized for research purpose. Benzofurans' structure is quite similar to the known recreational drug 3,4-methylenedioxymethamphetamine together with its active metabolite 3,4-methylenedioxyamphetamine. Benzodifurans are closely related to phenethylamines, but have more hallucinogens effects and muc Read More
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Post Mortem Redistribution of Drugs: Current State of Knowledge
Background: Drug concentrations obtained from post mortem samples do not necessarily reflect the concentrations at the time of death, and variations of concentration may be observed between different sites and/or different sampling times. These phenomena, collectively termed post mortem redistribution, concern numerous molecules (medications, drugs of abuse, gases, etc.) and can complicate the interpretation of Read More
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Volumes & issues
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Volume 31 (2025)
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Volume 30 (2024)
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Volume 29 (2023)
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Volume 28 (2022)
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Volume 27 (2021)
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Volume 26 (2020)
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Volume 25 (2019)
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Volume 24 (2018)
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Volume 23 (2017)
- Issue 46
- Issue 45
- Issue 44
- Issue 43
- Issue 42
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- Issue 12
- Issue 11
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- Issue 8
- Issue 7
- Issue 6
- Issue 5
- Issue 4
- Issue 3
- Issue 2
- Issue 1
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Volume 22 (2016)
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Volume 21 (2015)
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Volume 20 (2014)
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Volume 19 (2013)
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Volume 18 (2012)
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Volume 17 (2011)
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Volume 16 (2010)
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Volume 15 (2009)
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Volume 14 (2008)
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Volume 13 (2007)
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Volume 12 (2006)
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Volume 11 (2005)
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Volume 10 (2004)
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Volume 9 (2003)
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Volume 8 (2002)
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Volume 7 (2001)
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Volume 6 (2000)
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