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Therapeutic Modulation of the Microbiome in Oncology: Current Trends and Future Directions
Authors: Istuti Saraswat and Anjana GoelAvailable online: 14 November 2024More LessCancer is a predominant cause of mortality worldwide, necessitating the development of innovative therapeutic techniques. The human microbiome, particularly the gut microbiota, has become a significant element in cancer research owing to its essential role in sustaining health and influencing disease progression. This review examines the microbiome's makeup and essential functions, including immunological m Read More
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Advances and Challenges of Microneedle Assisted Drug Delivery for Biomedicals Applications: A Review
Authors: Shiv Bahadur, Radhika, Kantrol Kumar Sahu and Arun Kumar SinghAvailable online: 04 November 2024More LessMicroneedles have been explored as a novel way of delivering active ingredients into the skin. They have various advantages, such as quick and efficient drug delivery, mechanical stability, minimal pain, variable capacity and easy use. Microneedles are enabled for the delivery of vaccine, peptides, medicinal components and in cosmetology, which couldn’t go unnoticed. The novel approaches in the transdermal drug delive Read More
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Influence of Nanomedicine as a Smart Weapon on Multidrug Resistance in Cancer Therapy
Authors: Safal Kumar Paikray, Liza Sahoo, Nigam Sekhar Tripathy and Fahima DilnawazAvailable online: 31 October 2024More LessCancer is the leading cause of death worldwide. The effectiveness of chemotherapy in cancer patients is still significantly hampered by Multidrug Resistance (MDR). Tumors exploit the MDR pathways to invade the host and limit the efficacy of chemotherapeutic drugs that are delivered as single drugs or combinations. Further, overexpression of ATP-binding Cassette transporter (ABC transporter) proteins augments the efflu Read More
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Considerations and Challenges to Develop Drug-drug Coamorphous System: A Recent Update
Authors: Madhura Tiwari, Kavita Singh and Bappaditya ChatterjeeAvailable online: 30 October 2024More LessPoor water solubility of several drugs, especially BCS class II and IV drugs, restricts their dissolution and negatively affects oral absorption. Amorphization of drugs is a year-old approach to enhance solubility and dissolution of poorly water-soluble drugs. Polymeric amorphous systems have been proven effective but have disadvantages, such as low drug loading, high carrier content, etc. In a coamorphous system, a sm Read More
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Virus-like Particles-Based Vaccine to Combat Neurodegenerative Diseases
Available online: 29 October 2024More LessNeurodegenerative diseases are regarded as gradual, incurable conditions with an insidious onset. Alzheimer’s disease (AD) and Parkinson’s disease (PD) are two of the most prevalent neurodegenerative diseases reported globally. Developing effective treatment strategies for neurodegenerative diseases has remained a primary objective and a huge challenge for researchers. The therapeutic medications that Read More
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Tryptophan Stability and Palatability in the Food Formulation: A Review
Available online: 29 October 2024More LessTryptophan, an essential amino acid, plays a vital role in the synthesis of critical compounds like serotonin, melatonin, and niacin, which impact mood, sleep, and metabolic processes. It holds promise for improving the well-being of individuals with mood issues or sleep disorders through dietary enrichment. However, incorporating tryptophan into food products presents challenges related to stability, bitterness, and susce Read More
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Mechanisms of Bioactive Lipids to Modulate Master Regulators of Lipid Homeostasis and Inflammation in Metabolic Syndrome
Available online: 25 October 2024More LessMetabolic Syndrome (MetS) refers to the co-occurrence of a constellation of metabolic diseases in the same individual, such as abdominal/visceral obesity, insulin resistance or diabetes, alterations in the lipid profile (dyslipidemias), and/or hypertension, which promotes the development of other cardiometabolic and hepatic diseases. Dyslipidemia and metabolic dysfunction-associated steatotic liver disease (MASLD), previously ter Read More
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SIRT3, a New Hope in Liver Diseases from Pathogenic Mechanisms to Therapeutic Strategies
Authors: Sai-Ya Tan, Xiao-Xuan Chen, Rui Zhang, Pan Liu, Jian-Peng Wang, Ting Wang, and and Zhang-E XiongAvailable online: 24 October 2024More LessThe liver, the largest internal organ in the human body, regulates multiple reactions and processes, including detoxification, regeneration, and immune defense. Liver diseases have emerged as a significant global public health issue. Numerous studies have indicated that the mitochondrial deacetylase SIRT3 has played various roles in the pathogenesis and pathological progression of liver diseases. Objectives This review ai Read More
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Phytochemical Composition of Urtica dioica Essential Oil with Antioxidant and Anti-inflammatory Properties: In Vitro and In Vivo Studies
Available online: 24 October 2024More LessBackground Urtica dioica (Urticaceae) has outstanding medicinal and pharmacological properties. This investigation was aimed to assess the chemical composition, the total polyphenol and flavonoid content, antioxidant, anti-proliferative, and anti-inflammatory effects of Urtica dioica essential oil (UDEO). Methods GC/MS analysis was performed to assess the chemical composition, standard antioxidative test, the DPPH Read More
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Revolutionizing Influenza Treatment: A Deep Dive into Targeted Drug Delivery Systems
Authors: Sourav Ghosh, Sejuti Ray Chowdhury, Monosiz Rahaman, Biswajit Basu and Bhupendra PrajapatiAvailable online: 21 October 2024More LessInfluenza, a highly transmissible respiratory infection caused by influenza viruses A and B, poses a persistent threat to global public health due to its high mutation rate, ability to develop resistance to existing antiviral drugs, and capacity for rapid spread. Current treatment options, including four main classes of antiviral agents—adamantanes, neuraminidase inhibitors, RNA-dependent RNA polymerase inhibitors, and polymerase a Read More
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Discovery of New Natural Phytocompounds: The Modern Tools to Fight Against Traditional Bacterial Pathogens
Available online: 21 October 2024More LessOngoing competition between disease-causing bacteria and human hosts has resulted in the discovery of a wide array of antibacterials. The advent of antibacterials ushered in a promising period in the realm of microbiology, but its brilliance was short-lived and soon diminished. The excessive and incorrect use of antibacterials results in limited selection pressure on the targeted microorganisms, which in turn promotes the evol Read More
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Unwinding the Threads of Mesoporous Silica Nanoparticles as Cutting-Edge for the Management of Inflammation: An Updated Review
Authors: Priya Dhiman, Sukhbir Singh, Sandeep Arora, Neelam Sharma, Ritu Gulia and Ladli KishoreAvailable online: 11 October 2024More LessBackground Inflammation serves as a protective response to combat cellular and tissue damage. There is currently a wide array of synthetic and traditional therapies available for the treatment of inflammatory diseases. However, it is necessary to create a drug delivery system based on nanotechnology that can improve the solubility, permeability, and bioavailability of current treatments. Mesoporous silica nanoparticles ( Read More
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Role of Medicinal Plants in the Management of Multiple Sclerosis
Authors: Aaryan Gupta, Arpita Roy, Amit Roy, Vaseem Raja, Kuldeep Sharma and Rajan VermaAvailable online: 10 October 2024More LessThere is a rapid spread of Multiple Sclerosis disorder across the globe, around 2.8 million cases of Multiple Sclerosis in the world. Multiple Sclerosis (MS) is a chronic autoimmune disease of the central nervous system characterized by demyelination, neuroinflammation, and a wide spectrum of clinical manifestations. Many drugs have been tested on MS patients but there is no effective treatment for MS till now. So to inhibit the s Read More
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Jiangu Recipe Suppresses ER Stress-Induced Apoptosis and Inhibits Extracellular Matrix Degradation in Chondrocytes through Upregulating SIRT1 Expression
Authors: Jie Qiao, Chang Cheng, Gongxu Yang, Chuanqi Zhong, Jun Jin and Bin WuAvailable online: 09 October 2024More LessObjective This study aimed to explore the effects of Jiangu Recipe (JGR) on chondrocyte responses under tert-Butyl hydroperoxide (TBHP)-induced oxidative stress, specifically focusing on apoptosis and extracellular matrix (ECM) degradation. Methods Chondrocytes were treated with varying JGR concentrations, and cell viability was assessed. The impact of JGR on TBHP-induced apoptosis and protein expression levels of apopt Read More
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Bridging the GAP: Probiotic Douches Redefining the Feminine Hygiene
Authors: Akash Kumar, Sadique Hussain, Nitya Srivastava, Gurvinder Singh, Monica Gulati and Rajesh KumarAvailable online: 09 October 2024More LessVaginal douching is a centuries-old practice which is still in use, especially among adolescents. “Probiotic douches” are the vaginal douches that are formulated with probiotics and are intended to restore or maintain the vaginal microbiome balance. Probiotic douches are a new type of feminine hygiene product that claims to promote a balanced vaginal microbiome and improve overall well-being. However, the evidence supporti Read More
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Integrated Transcriptomics and Metabolomics Studies Reveal Steroid Biosynthesis Pathway and BCL2 Inhibitory Diazo-Progesterone of Drimia indica for Conservation and Sustainable Utilization
Authors: Vivek Shit, Mahesh Kumar Dhakar and Manoj KumarAvailable online: 09 October 2024More LessBackground This study is the first report on the sequence of the transcriptome of Drimia indica, a non-model plant with medicinal properties found in a forest tribal belt, using the Illumina NovaSeq platform. The primary objectives of this study were to elucidate the gene expression profiles in different tissues, identify key regulatory genes and pathways involved in secondary metabolite biosynthesis, and explore the plant's pote Read More
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Advances in Colon-Targeted Drug Delivery Systems: Innovative Strategies for Treating Colonic Disorders and Prospects for the Future
Authors: Jyoti Singh, Ashutosh Solanki, Gaurav Singh Sikarwar and Niraj Kumar SinghAvailable online: 09 October 2024More LessColon-specific targeting delivery systems have drawn a great deal of attention because they represent potential vehicles for treating colonic disorders like diverticulitis, colitis, salmonellosis, Crohn’s disease, etc. with less systemic adverse effects as well as for the better oral delivery of many therapeutics that are prone to enzymatic and acidic deterioration in the upper GI tract. Smart polymeric delivery systems in partic Read More
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Dihydroartemisinin Modulates Prostate Cancer Progression by Regulating Multiple Genes via the Transcription Factor NR2F2
Authors: Yong Shao, Yunhui Chan, Chuan Zhang, Rong Zhao and Yuxin ZuAvailable online: 03 October 2024More LessObjective This study aimed to investigate the effect of dihydroartemisinin (DHA) on DU145 cells and the role of NR2F2 (COUP-TFII) and its potential target genes in this process. Methods GSE122625 was used to identify differentially expressed genes (DEGs) between the DHA-treated and control groups. Protein-protein interaction (PPI) network analysis was performed to identify hub genes, and the ChEA3 database was used to ide Read More
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The Gut Health Revolution: Herbs and Dietary Phytochemicals in Balancing Gut Microbiota for Optimal Human Health
Available online: 27 September 2024More LessThe gut microbiota is a varied population of microorganisms that live in the human gastrointestinal system. Emerging research emphasizes the importance of this microbial ecology in general health and its influence on a variety of disorders. The review explores the synergy between herbal treatment and traditional medicine, emphasizing their cultural significance and therapeutic benefits. It delves into the intricate relations Read More
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Biomarkers and Novel Therapies of Diabetic Neuropathy: An Updated Review
Available online: 27 September 2024More LessDiabetic neuropathy is a persistent consequence of the biochemical condition known as diabetes mellitus. As of now, the identification and management of diabetic neuropathy continue to be problematic due to problems related to the safety and efficacy of existing therapies. This study examines biomarkers, molecular and cellular events associated with the advancement of diabetic neuropathy, as well as the existing ph Read More
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