Current Proteomics - Online First

Aims This study aims to gain insights into the EhSec1 binding mechanism and the corresponding amino acids responsible for interacting with the amoebic SNARE proteins, EhSyntaxin1A/1B, which would enable to create a platform for further exploration of the functions and applications of EhSec1 in managing amoebiasis. Background Parasitic protozoa have long been responsible for increasing the burden on healthcare. Ho Read More

Background and Objectives Venomous scorpions play a crucial role in medicine and public health. Buthotus saulcyi scorpion is known as one of the most populous species in East Asia and Iran, while its venom proteome has still not been fully determined. Aims In the current research, the proteomic profile of Buthotus saulcyi scorpion venom to determine the structural and functional characteristics of its compounds used f Read More

Abiotic stress, including drought, salinity, extreme temperatures, and light intensity, profoundly affects plant growth and development. Plants being sessile cannot escape the stress conditions,, thus have developed either evading or tolerance mechanisms during evolution. In plants several processes are affected by drought e.g. there is inhibition of growth, reduction in photosynthesis, and yield, and increased membrane da Read More

The gastrointestinal tract hosts a complex ecosystem of microorganisms, with rectum playing a critical role in microbial diversity and health. This manuscript provides a comprehensive overview of rectal microbes, their functions, and the latest technological advancements in studying and manipulating these microorganisms for therapeutic purposes. Key microbial phyla in the rectum include Firmicutes, Bacteroidetes, Actin Read More

Background Sepsis is defined as the extreme response of a body to an infection, leading to untimely death if left untreated. The human gut microbiome is characterized by the presence of several microorganisms in the gastrointestinal tract. This study provides insight into the potential therapeutic effects of a peptide present in the human gut microbiome that helps control sepsis. Aim This study aimed to explore the the Read More

Background Necrosis, a form of uncontrolled cell death, can be triggered by a variety of stressors, including infection, injury, toxins, and ischemia. Such necrotic events, particularly when induced by pathogenic infections, can lead to severe health complications. The mixed lineage kinase domain-like pseudokinase (MLKL) has been identified as a crucial drug target for mitigating necrosis. Objective The objective of this stud Read More

Introduction Bermudagrass (Cynodon dactylon L.) simultaneously has three types of stems: shoots, stolons, and rhizomes, which lays the basis for the fast clonal growth of this important warm-season turfgrass species. However, the mechanisms underlying the differentiation, growth, and development of the three types of stems remain unclear. Methods In this study, the annotation information of the assembled bermudag Read More

Background In-silico study plays an important role in bioinformatics. It is a fast-expanding field to modelling, predicting and explaining biological activity at the molecular level using computational methods. Peroxidases are heme or non-heme-containing key antioxidant enzyme belonging to the oxidoreductase family. They can bioremediate the different environmental pollutants such as dioxins, petroleum hydrocarbons, synt Read More

Background Saffron (Crocus sativus), also known as Red Gold has shown anticancer activity, but the molecular mechanisms underlying its potential therapeutic effects are not fully understood. Objective This study investigates the anticancer effects of safranal on cervical cancer, one of the most common cancer types in women worldwide and elucidates the molecular mechanism underlying these effects through bioinformatics an Read More