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Molecular Mechanisms of Antiproliferative Effects of Safranal on Cervical Cancer: Evidence from Bioinformatics Analysis
Authors: Souandaou Athoumani Ali, Gul Ozcan and Nihal Omur BulanAvailable online: 01 January 2025More LessBackground Saffron (Crocus sativus), also known as Red Gold has shown anticancer activity, but the molecular mechanisms underlying its potential therapeutic effects are not fully understood. Objective This study investigates the anticancer effects of safranal on cervical cancer, one of the most common cancer types in women worldwide and elucidates the molecular mechanism underlying these effects through bioinformatics an Read More
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NaturePred: A Tool for Revolutionizing Natural Product Classification with Artificial Intelligence
Available online: 01 January 2025More LessBackground The identification and classification of natural products are vital in drug discovery and bioactive compound exploration. Traditional methods are laborious and time-consuming, necessitating innovative tools for accurate predictions using advanced AI techniques. Objectives This paper presents NaturePred, a user-friendly tool designed to predict the class of natural products and calculate eight physicochemical pr Read More
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Identification of a Ubiquitination-Related Signature for Ovarian Cancer Based on 101 Combinations of Machine Learning Methods
Authors: Miao He, Jiaming Cheng, Yu Guo, Minmin Yu and Changsong LinAvailable online: 13 December 2024More LessBackground Ovarian cancer is the third most common gynecological cancer worldwide. The majority of ovarian cancer instances are identified at later stages of progression, resulting in a significantly elevated mortality rate. Additionally, the absence of reliable prognostic biomarkers significantly limits the effectiveness of prediction and personalized treatment approaches. Ubiquitination, a protein modification process Read More
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Decoding Glycobiomarkers in Non-Alcoholic Steatohepatitis (NASH) and Related Hepatocellular Carcinoma (HCC)
Authors: Savita Bansal, Archana Burman, Aparajita Sen and Meenakshi VachherAvailable online: 06 November 2024More LessThe incidence of Hepatocellular carcinoma (HCC) is rising at an alarming rate. It is now the third leading cause of cancer deaths worldwide. Non-alcoholic fatty liver disease (NAFLD) and its more aggressive form of non-alcoholic steatohepatitis (NASH) are emerging as significant risk factors for liver cirrhosis and HCC. Post-translational modifications in proteins especially glycosylation leading to the synthesis of glycoproteins h Read More
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Comparative Clinical, Proteomic, and Serologic Evaluation in Non-Hospitalized COVID-19 Patients and Healthy Individuals
Authors: Solmaz Alihosseini, Hakimeh Zali, Ahmad Majd, Monireh Movahedi and Hamed AbdollahiAvailable online: 14 October 2024More LessIntroduction The COVID-19 pandemic, caused by the SARS-CoV-2 virus, has had a significant global impact since its declaration as a public health emergency in January 2020. Symptoms of COVID-19 can range from mild to severe, including fever, cough, fatigue, and shortness of breath. This study aimed to investigate the clinical symptoms and proteomic differences between non-hospitalized COVID-19 patients and healthy in Read More
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Determination of FGFR1 Functions in Cytarabine Treatment of Acute Myeloid Leukemia Through Bioinformatics Analysis
Authors: Sema Misir, Serap Ozer Yaman, Okan Aykac, Osman Akidan, Irem Bozbey Merde and Ceylan HepokurAvailable online: 09 October 2024More LessAim Among the most prevalent subtypes of acute leukemia is acute myeloid leukemia (LAML). Consequently, it is essential to understand the molecular causes of LAML and find its predictive and diagnostic biomarkers. The aim of this study is to determine the molecular functions of fibroblast growth factor receptor 1(FGFR1) involved in LAML pathogenesis and its potential therapeutic effect for AML treatment. Metho Read More
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In Vitro and In Silico Evaluation of Caffeic and Ferulic Acids Involvement in the Translocation of Glucose Transporter 4
Authors: Najlaa Bassalat, Shahd Abu Naim, Waseim Barriah, JArg Labahn, Siba Shanak and Hilal ZaidAvailable online: 08 October 2024More LessBackground Insulin is a key hormone in our systems. Upon binding of insulin to its receptors in fat and muscle tissues, tens of proteins in the insulin signaling pathway are involved in the process of GLUT4 vesicle recruitment to the Plasma Membrane (PM) and the absorption of serum glucose. Deficits in the aforementioned pathway lead to insulin resistance and eventually to Type II Diabetes Mellitus. Objective We appreciate th Read More
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Identifying Prostaglandin D2 Synthase in Urine: A Potential Biomarker for Bladder Cancer
Authors: Lia-Beng Tan, Yu-Chang Tyan, Jen-Yi Hsu, Kun-Hung Hsen, Pao-Chi Liao and How-Ran GuoAvailable online: 03 October 2024More LessIntroduction Proteins present in body fluids harbor the potential to act as markers for both diagnosing diseases and exploring their underlying mechanisms. As urine can be easily obtained non-invasively, analyzing its proteins is an ideal approach to identifying biomarkers for bladder cancer. This study aimed to identify proteins in urine that could serve as biomarkers for bladder cancer. Method Urine samples were collected fr Read More
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Identification of Novel Biomarkers for Post-Kasai Portoenterostomy in Biliary Atresia through Shotgun Proteomics Analysis
Available online: 13 September 2024More LessIntroduction Biliary Atresia (BA) causes neonatal cholestasis jaundice. The primary therapeutic treatment for BA is the Kasai portoenterostomy. Current diagnostic approaches for BA are imprecise and time-consuming, making early diagnosis crucial for successful treatment outcomes. Objective This study aims to analyze proteins from Peripheral Blood Mononuclear Cells (PBMCs) obtained from children with BA compare Read More
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