Current Proteomics - Current Issue

Adropin is 76-amino acids protein. It was discovered in 2008. Adropin expression was found in the liver, brain, heart, kidneys, pancreas, testis and ovary, umbilical vein, coronary artery endothelial cells, aortic smooth muscle cells and monocytes/macrophages. Adropin is involved in energy balance, and it has an endothelial protective effect. Changes in adropin content have been found in many diseases and disorders, such Read More

Neuroblastoma, a malignancy predominantly affecting young children, originates from neural crest cells in the sympathetic nervous system. It primarily appears in the adrenal gland but can also affect nerve tissues in regions, such as the chest, neck, abdomen, and pelvis. Despite advancements in treatment, high-risk neuroblastoma patients often face poor prognoses, underscoring the need for ongoing research. Read More

Purpose The molecular properties of TLSs in pancreatic cancer are still not well comprehended. This research delved into the molecular properties of intratumoral TLSs in pancreatic cancer through the exploration of multi-omics data. Methods Seven key genes were identified through Cox regression analysis and random survival forest analysis from a total of 5908 genes related to TLSs. These genes were utilized to constru Read More

Background A pivotal impetus has led to the development of numerous small molecules to develop therapeutic strategies for type 2 diabetes. Novel heterocyclic derivatives are now available with expansive pharmacological activity designed specifically to activate Glucokinase (GK) in the body. This target is of particular significance in antidiabetic drug design since it is a newly validated target. Individuals with type 2 diabetes are Read More