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image of Network Pharmacology and Computational Approach to Explore the Potential Underlying Mechanism of Centella asiatica in the Treatment of Diabetes Mellitus

Abstract

Background

is a tropical medicinal herb traditionally used for the treatment of different diseases, such as arthritis, kidney disease, diabetes mellitus, . Diabetes mellitus is emerging as a global health concern, demanding research to provide insights into it.

Objective

The current research study aimed at employing the Network Pharmacology and Molecular Docking approach to unearth and validate the possible molecular mechanism involved in the treatment of diabetic mellitus with herbal constituents from .

Methods

The phytocompounds and targets of were screened from different databases. An herb-core-target-ingredient-diabetes mellitus network was established Cystoscope 3.7.2. Next, Go and KEGG enrichment analysis was performed. Lastly, the interaction between ligands and targets was investigated molecular docking.

Results

According to the results obtained, we identified 49 core targets of diabetes mellitus and 37 active ingredients of . Next, Go and KEGG resulted in a total of 455 biological processes for the treatment of diabetes mellitus. The KEGG enrichment analysis reported that the targets were related to metabolic pathways, insulin signaling pathways, glycolysis/gluconeogenesis, oxidative stress, insulin resistance, . On the basis of KEGG enrichment and protein-protein interaction, we selected Fructose-1-6 bisphosphate1 (FBP1), Glucokinase (GCK), Cytochromes P450 (CYP19A1), fatty acid binding protein 1 (FABP1), Interleukin 2 (IL2) and angiotensin-converting enzyme (ACE), and phytocompounds from for docking. From the docking study, it was concluded that several targets had a stable binding affinity with phytocompounds.

Conclusion

We explored the biological mechanism of phytocompounds involved in the treatment of diabetes mellitus through different biological processes and signaling pathways, and lastly, docking provides us commending results that direct for experiments ahead.

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2025-01-28
2025-04-25

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Network Pharmacology and Computational Approach to Explore the Potential Underlying Mechanism of Centella asiatica in the Treatment of Diabetes Mellitus
Bentham Science Publishers ; https://doi.org/10.2174/0115701646364860250102115855
/content/journals/cp/10.2174/0115701646364860250102115855
/content/journals/cp/10.2174/0115701646364860250102115855
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  • Article Type:     Research Article
Keywords: network pharmacology ; Centella asiatica ; phytocompounds ; diabetes mellitus ; molecular docking

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