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Flaxseed Oil: Safeguarding Neurological Health through Apoptosis and Oxidative Damage Defense
Authors: Devendra Kumar Mishra, Himani Awasthi, Dipti Srivastava, Zeeshan Fatima and Lucy MohapatraAvailable online: 15 November 2024More LessThe present study aims to investigate the neuroprotective properties of flaxseed oil (FSO) in reducing cadmium-induced neurotoxicity. The neuroprotective properties of FSO were observed in rats by examining the expression of caspase-3 and Bcl-2 to determine the antiapoptotic capabilities of FSO.
MethodsRats were given cadmium orally at a dosage of 5 mg/kg/day for 30 days, along with flaxseed oil (FSO) at doses of 2ml/kg/day and 3ml/kg/day for the same duration. The Morris watermaze test (MWM) and the Novel object recognition test (NOR) were performed to evaluate learning and memory abilities. We quantified the amounts of glutathione (GSH), malondialdehyde (MDA), nitric oxide (NO), and acetylcholinesterase inhibitory activity (AChE) in the entire brain homogenate. Additionally, apoptosis and histopathology studies were conducted on rat brain tissues.
ResultsIntoxication with cadmium was associated with significant impairment of learning and memory in Morris watermaze (MWM) and novel object recognition (NOR) tests. The group that consumed Cd showed elevated levels of MDA, NO, and AChE in the brain homogenate, higher levels of caspase-3 and Bcl-2, and decreased levels of GSH compared to the control group. Animals treated with FSO exhibited improved learning and memory function, along with balanced levels of oxidative and cholinergic activity in brain tissue. Additionally, levels of caspase-3 and Bcl-2 were reduced in a similar way to the control group.
ConclusionsThe study demonstrates that flaxseed oil has positive effects by raising GSH and anti-apoptotic potential levels while reducing MDA, NO, and AChE levels in the brain. This contributes to neuroprotection and decreases neuronal death, as supported by histopathological findings.
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Physicochemical Characteristics and Antioxidant Activity of Murici Pulps (Byrsonima spp., Malpighiaceae) Sold in the Municipality of Santarém-PA, Brazil
Available online: 04 November 2024More LessIntroductionMurici is valued by the local population for its healing, anti-inflammatory, and antioxidant properties, which are attributed to its phenolic compounds and carotenoids, although its quality and properties are not well-known.
ObjectiveThis research aimed to evaluate the quality of murici pulp (Byrsonima spp.) commercialized in some places of Santarém, Pará, Brazil.
MethodsMurici pulp samples were collected in Santarém and Curuá, PA, between October 2022 and January 2023. The samples were packed in plastic containers and stored in a refrigerated laboratory. Physicochemical analyses included pH, titratable acidity, total soluble solids, ash content, moisture, phenolic compounds, proteins, and sugars, following standard methods. Antioxidant activity was measured using DPPH, ABTS, and FRAP assays.
ResultsMurici pulp pH ranged from 3.2 to 3.6, all within legal limits, indicating higher acidity suitable for consumption. Titratable acidity ranged from 15.89 to 63.57 meq kg−1, meeting regulatory standards. Ash content varied from 0.15% to 0.86%, moisture from 75.11% to 83.58%, and phenolic compounds from 2.73 to 3.64 mg GA g−1. Significant statistical differences were observed in all analyses, highlighting the nutritional and antioxidant potential of the pulp.
ConclusionMurici pulp samples showed low sugar and starch concentrations but high total acidity and antioxidant capacity (DPPH, ABTS, and FRAP). pH levels met legal standards, with significant variations due to ripeness and environmental factors. The study underscores murici's health benefits and quality variations influenced by environmental conditions and processing factors.
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Diosgenin Unveiled: From Nutritional Insights to Nano Applications and Molecular Marvels
Authors: Manisha Thakur, Neeru Vasudeva and Sunil SharmaAvailable online: 30 October 2024More LessIntroductionDiosgenin (DSG) is a steroidal sapogenin found in plants such as
Dioscorea tokoro Makino ex Miyabe, Trigonella foenum-graceum, and Solanum virginianum, and is utilized as a natural source of steroidal hormones. It exhibits anti-inflammatory, anti-apoptotic, anti-oxidant, and various other pharmacological properties, making it a reliable candidate for research purposes. The aim of this review is to provide researchers with a scientific basis for the target-specific bio-potential of DSG as an ethnomedicine and to underscore its potential for drug design and therapy modifications in the future.
MethodsRelevant literature search up to the current year by using online databases such as Scopus, Google Scholar, PubMed, Research Gate, and Science Direct by applying related search terms.Results: This review first addressed the green nanotechnology that is widely adopted to improve DSG’s pharmacokinetic profile, and then listed numerous nano-formulations of DSG for enhancement of their physical properties. At last, this article explored the molecular action of DSG on NF-ĸB, TGF-β1/Smad, AMPK/ACC/CPT-1A & SERBP-1c/FAS, etc. that are pathologically involved in a variety of diseases for better understanding such as limited clinical research has been conducted to date.
ConclusionOverall, the current review tries to update all information about DSG's nutritional benefits, its application as nanomedicine, and diverse pharmacological actions based on various molecular targets for its commendable pre-clinical and clinical applications.
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Boon Plant Calendula Officinalis Linn. (CO): An Investigation, Ethnopharmacological, Phytoconstituent Review’
Authors: Naincy Gupta, Ankur Choubey, Naveen Gupta, Dharmendra Rajput and Mukesh Kumar ShuklaAvailable online: 23 October 2024More LessIntroductionCalendula (English Marigold), or “Pot Marigold,” is a well-known herbal plant from the family of Asteraceae, which has been used for thousands of years as a medicinal herb. It is one of the most widely used aromatic herbs in the Ayurvedic system of medicine, which is based on the ethnological significance of the plant. Extracts of this plant have been found to possess a range of therapeutic benefits, including anti-hyperlipidaemia, cardiovascular and antidiabetic properties, as well as antioxidant and anti-inflammatory properties. Additionally, it has been found to be effective in wound healing and has anti-cancer, anti-hepatitis, antibacterial, and antiretroviral properties. Traditionally, it has been used as a herbal remedy to treat skin tumours and dermatological lesions as well as ulcers and swellings, as well as nervous disorders.
AimsIn addition to ethnopharmacology, pharmacology, and toxicology, this abstract also covers the morphology, microscopy, phytoconstituents, pharmacological reports, phytochemistry, and toxicity of the well-known Calendula species. Cosmetic ingredients derived from the C officinalis plant include extracts, flower oil, seed oil, and other components of the plant. These components include minerals, carbohydrates, and lipids; phenolic acids; flavonoids; tannins; coumarins; sterols; steroids; monoterpenes; sesquiterpene; triterpenes; tocopherol; quinones; amino acids; and resins. A chemical analysis of these ingredients reveals a wide variety of chemical compounds, including amino acid, triterpenoid, quinone, flavonoid, volatile oil, carotenoid, and other chemicals. Some Calendula officinalis species have medicinal value, and a literature review highlights their utilization.
ResultsCalendula officinalis has a wide range of medicinal properties, ranging from antibacterial and antifungal properties to anthelmintic and antiviral properties. Additionally, it has antioxidant and hepatoprotective properties, as well as cardioprotective and wound-healing properties. Furthermore, it has been used to treat gastrointestinal, eye, and skin diseases. The plant has the potential to be a significant medicinal resource for mankind. It exhibits anti-HIV, cytotoxic, anti-inflammatory, hepatoprotective, and spasmolytic properties. The plant is used in almost 200 cosmetic formulations and has the potential for further research.
ConclusionThis review emphasizes the future scope of Calendula species, focusing on their multifarious biological activities and potential applications as medicinal agents. This research fills gaps in existing studies, allowing researchers to validate traditional claims and advance the safe and effective use of CO in treating various ailments.
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Nature's Pharmacy: Bioactive Components and their Role in Alleviating Rheumatoid Arthritis
Available online: 08 October 2024More LessAn essential pathogenic aspect of rheumatoid arthritis (RA) is the loss of bones, which ultimately causes RA patients' quality of life to diminish seriously. The main reason for bone loss in RA is an imbalance in bone metabolism, marked by the breakdown of bone through osteoclast activity and inadequate bone formation by osteoblasts. Contemporary medications somewhat diminish the process of bone deterioration, but there are still several drawbacks. Natural medicines have several benefits, including a wide spectrum of biological actions and few side effects, making them a valuable source of new therapeutic compounds. They have developed into a hub for countless researchers to examine various diseases and provide healing medications. Natural medicine research for the treatment of RA has made impressive advancements in recent years. These natural bioactive compounds primarily contain terpenes, alkaloids, glycosides, flavonoids, and polyphenols. Most therapeutic natural bioactive compounds for the treatment of RA comprise the following: sinomenine, ginsenoside, icariin, paeoniflorin, triptolide, resveratrol, and epigallocatechin-3-gallate. A quick summary of the mechanisms of action of naturally occurring bioactive chemicals that may be used as RA treatments is provided.
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High Protein Functional Breads for Sustainable Nutrition: A Futuristic Review
Authors: U.S. Wijewardhana, M.A. Jayasinghe, I. Wijesekara and K.K.D.S. RanaweeraAvailable online: 12 September 2024More LessBread is consumed by almost every household worldwide as a dietary staple. Most commercial bread products are made with refined wheat flour and have an incomplete nutritional profile. Refined wheat bread is comparatively lower in protein with an unbalanced amino acid profile and is low in fibre, vitamins, minerals, and phytochemicals. The enrichment of bread to increase nutritional quality and functionality while preserving sensory properties has been a point of interest for decades. Legumes and pulses are nutrient-dense plant ingredients capable of increasing and balancing the nutritional value of bread, especially the protein quality. The review aims to explore possible legumes and pulses for bread enrichment and recent developments in the study area, balancing the amino acid profile of bread, the behaviour of legume anti-nutritional factors in bread making, enhancing protein metabolism, associated challenges, and future directions. The Enrichment of bread with legumes and pulses will ensure a high protein intake, a balanced amino acid profile, and additional vitamin, mineral, and phytochemical content compared to refined wheat bread. The development and commercialization of enriched functional bread products will benefit a vast population, especially in developing countries.
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