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image of Diosgenin Unveiled: From Nutritional Insights to Nano Applications and Molecular Marvels

Abstract

Introduction

Diosgenin (DSG) is a steroidal sapogenin found in plants such as

Dioscorea tokoro Makino ex Miyabe, Trigonella foenum-graceum, and Solanum virginianum, and is utilized as a natural source of steroidal hormones. It exhibits anti-inflammatory, anti-apoptotic, anti-oxidant, and various other pharmacological properties, making it a reliable candidate for research purposes. The aim of this review is to provide researchers with a scientific basis for the target-specific bio-potential of DSG as an ethnomedicine and to underscore its potential for drug design and therapy modifications in the future.

Methods

Relevant literature search up to the current year by using online databases such as Scopus, Google Scholar, PubMed, Research Gate, and Science Direct by applying related search terms. This review first addressed the green nanotechnology that is widely adopted to improve DSG’s pharmacokinetic profile, and then listed numerous nano-formulations of DSG for enhancement of their physical properties. At last, this article explored the molecular action of DSG on , . that are pathologically involved in a variety of diseases for better understanding such as limited clinical research has been conducted to date.

Conclusion

Overall, the current review tries to update all information about DSG's nutritional benefits, its application as nanomedicine, and diverse pharmacological actions based on various molecular targets for its commendable pre-clinical and clinical applications.

© 2024 Bentham Science Publishers
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2024-10-30
2024-11-26

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Diosgenin Unveiled: From Nutritional Insights to Nano Applications and Molecular Marvels
Bentham Science Publishers ; https://doi.org/10.2174/0126668629330184240914131424
/content/journals/cff/10.2174/0126668629330184240914131424
/content/journals/cff/10.2174/0126668629330184240914131424
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  • Article Type:     Review Article
Keywords: nanomedicine, ethnomedicine, molecular targets, dietary supplements ; Diosgenin, herbal drugs

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