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image of A Review on Functional Foods and Nutraceuticals in the Management of Epilepsy

Abstract

Epilepsy is a persistent neurological disorder distinguished by repetitive episodes of seizures that presents notable complexities for patients and healthcare providers. While pharmacotherapy remains fundamental in its management, the emergence of functional foods and nutraceuticals has garnered attention as adjunctive therapeutic options. This review examines the role of functional foods and nutraceuticals in epilepsy management, examining their mechanisms of action, evidence-based efficacy, and safety profiles. The review delineates various functional foods and nutraceuticals exhibiting promise in epilepsy management, encompassing omega-3 fatty acids, the ketogenic diet, flavonoids, vitamins, and minerals. Mechanically, these substances modulate neuronal excitability, neurotransmitter release, and neuroinflammation, thus exerting anticonvulsant effects. Furthermore, they may augment the efficacy of conventional antiepileptic drugs while mitigating their adverse effects. Clinical investigations assessing the efficacy of functional foods and nutraceuticals in epilepsy management have yielded encouraging findings, albeit necessitating further inquiry to ascertain optimal dosing protocols and long-term safety considerations. Additionally, challenges such as bioavailability, formulation standardization, and patient adherence warrant attention to optimize therapeutic outcomes.

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2024-12-03
2025-01-24

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/content/journals/cff/10.2174/0126668629329853241028081157
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A Review on Functional Foods and Nutraceuticals in the Management of Epilepsy
Bentham Science Publishers ; https://doi.org/10.2174/0126668629329853241028081157
/content/journals/cff/10.2174/0126668629329853241028081157
/content/journals/cff/10.2174/0126668629329853241028081157
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  • Article Type:     Review Article
Keywords: neurodegeneration ; food bioactives ; human health ; epilepsy management ; Status epilepticus ; dietary therapy

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