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2000
Volume 1, Issue 1
  • ISSN: 2666-8629
  • E-ISSN: 2666-8637

Abstract

(Linn.), commonly known as flaxseed, belongs to the family Linaceae. Flaxseed is a crop of blue flowers that produce small, flat seeds of golden yellow to reddish-brown color. It is a native of the Mediterranean and West Asia. Due to its health benefits associated with the high content of linolenic acid (ALA), flaxseed has played a major role in diet and research. The ALA is an essential omega-3-fatty acid, and also due to its presence a major lignan, . secoisolariciresinol diglucoside (SDG). There is also a wide range of uses of flaxseed oil in skin health, anticoagulants, anticancer, ulcer treatment, muscle growth, and weight loss. The nutritional composition of flaxseed is about 30% carbohydrate, 18% protein, and 39% fat. Flaxseed contains most carbohydrates in the form of fiber and contains more than 45% omega-3 fatty acids. It also contains dietary fibers, proteins and polyunsaturated fatty acids. All the ingredients possess different health benefits. Although plant resources are the key ingredient in drug discovery, the popularity of flaxseed always fascinate scientists, the number of articles giving information about the chemical components of flaxseed and its potential clinical use is very little. This review provides a systematic summary of the research completed over the past decade and provides an up-to-date summary of the various bioactive and outlines the relationship between the nutritional and pharmacological use of flaxseed and its chemical ingredients.

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References

  1. Boakye-YiadomM. KumadohD. AdaseE. WoodeE. Medicinal plants with prospective benefits in the management of peptic ulcer diseases in Ghana.BioMed Res. Int.202120215574041557404910.1155/2021/557404134036100
    [Google Scholar]
  2. AhsanF. AnsariT.M. UsmaniS. BaggaP. An insight on silk protein sericin: From processing to biomedical application.Drug Res. (Stuttg.)201868631732710.1055/s‑0043‑12146429132177
    [Google Scholar]
  3. NoorG. AhmadM.A. AhsanF. MahmoodT. ArifM. KhushtarM. A phytochemical and ethnopharmacological recapitulation on Hamelia patens.Drug Res. (Stuttg.)202070518819810.1055/a‑1131‑785632227313
    [Google Scholar]
  4. AnsariR. ZarshenasM.M. DadbakhshA.H. A review on pharmacological and clinical aspects of Linum usitatissimum L.Curr. Drug Discov. Technol.201916214815810.2174/157016381566618052110113629779483
    [Google Scholar]
  5. ShimY.Y. GuiB. ArnisonP.G. WangY. ReaneyM.J.T. Flaxseed (Linum usitatissimum L.) bioactive compounds and peptide nomenclature: A review.Trends Food Sci. Technol.20143852010.1016/j.tifs.2014.03.011
    [Google Scholar]
  6. AdlercreutzH. Lignans and human health.Crit. Rev. Clin. Lab. Sci.2007445-648352510.1080/1040836070161294217943494
    [Google Scholar]
  7. SinghK.K. MridulaD. RehalJ. BarnwalP. Flaxseed: A potential source of food, feed and fiber.Crit. Rev. Food Sci. Nutr.201151321022210.1080/1040839090353724121390942
    [Google Scholar]
  8. BaschE. BentS. CollinsJ. Natural Standard Resource CollaborationFlax and flaxseed oil (Linum usitatissimum): A review by the Natural Standard Research Collaboration.J. Soc. Integr. Oncol.2007539210510.2310/7200.2007.00517761128
    [Google Scholar]
  9. RheeY. BruntA. Flaxseed supplementation improved insulin resistance in obese glucose intolerant people: A randomized crossover design.Nutr. J.2011104410.1186/1475‑2891‑10‑4421554710
    [Google Scholar]
  10. PrasadK. Flaxseed and cardiovascular health.J. Cardiovasc. Pharmacol.200954536937710.1097/FJC.0b013e3181af04e519568181
    [Google Scholar]
  11. ThakurG. MitraA. PalK. RousseauD. Effect of flaxseed gum on reduction of blood glucose and cholesterol in type 2 diabetic patients.Int. J. Food Sci. Nutr.200960Suppl. 612613610.1080/0963748090302273519548163
    [Google Scholar]
  12. HuC. YuanY.V. KittsD.D. Antioxidant activities of the flaxseed lignan secoisolariciresinol diglucoside, its aglycone secoisolariciresinol and the mammalian lignans enterodiol and enterolactone in vitro.Food Chem. Toxicol.200745112219222710.1016/j.fct.2007.05.01717624649
    [Google Scholar]
  13. KajlaP. SharmaA. SoodD.R. Flaxseed-a potential functional food source.J. Food Sci. Technol.20155241857187110.1007/s13197‑014‑1293‑y25829567
    [Google Scholar]
  14. De SilvaS.F. AlcornJ. Flaxseed lignans as important dietary polyphenols for cancer prevention and treatment: Chemistry, pharmacokinetics, and molecular targets.Pharmaceuticals (Basel)20191227610.3390/ph1202006831060335
    [Google Scholar]
  15. WatanabeY. OhataK. FukanokiA. Antihypertensive and renoprotective effects of dietary flaxseed and its mechanism of action in deoxycorticosterone acetate-salt hypertensive rats.Pharmacology20201051-2546210.1159/00050278931514180
    [Google Scholar]
  16. SalemM.A. EzzatS.M. GiavaliscoP. SattarE.A. El TanboulyN. Application of a comprehensive metabolomics approach for the selection of flaxseed varieties with the highest nutritional and medicinal attributes.Yao Wu Shi Pin Fen Xi202129910.38212/2224‑6614.3347
    [Google Scholar]
  17. NemethM. EisenschenkI. EngelmannA. Flaxseed oil as omega-3 polyunsaturated fatty acid source modulates cortisol concentrations and social dominance in male and female guinea pigs.Horm. Behav.202113410502510502910.1016/j.yhbeh.2021.10502534242874
    [Google Scholar]
  18. KezimanaP. DmitrievA.A. KudryavtsevaA.V. RomanovaE.V. MelnikovaN.V. Secoisolariciresinol diglucoside of flaxseed and its metabolites: Biosynthesis and potential for nutraceuticals.Front. Genet.2018964164710.3389/fgene.2018.0064130619466
    [Google Scholar]
  19. YasmeenM. NisarS. TavallaliV. KhalidT. A review of phytochemicals and uses of flaxseed.Int. J. Chem. Biochem. Sci.20181375
    [Google Scholar]
  20. HosseinianF.S. BetaT. Patented techniques for the extraction and isolation of secoisolari-ciresinol diglucoside from flaxseed.Recent Pat. Food Nutr. Agric.200911253110.2174/221279841090101002520653523
    [Google Scholar]
  21. CarterJ. Potential of flaxseed and flaxseed oil in baked goods and other products in human nutrition.Cereal Foods World199338753759
    [Google Scholar]
  22. RabetafikaH.N. Van RemoortelV. DanthineS. PaquotM. BleckerC. Flaxseed proteins: Food uses and health benefits.Int. J. Food Sci. Technol.20114622122810.1111/j.1365‑2621.2010.02477.x
    [Google Scholar]
  23. MuirA.D. WestcottN.D. Quantitation of the lignan secoisolariciresinol diglucoside in baked goods containing flax seed or flax meal.J. Agric. Food Chem.20004894048405210.1021/jf990922p10995312
    [Google Scholar]
  24. BakkeJ. KlostermanH. A new di glucoside from flaxseed.North Dakota Acad Sci195611822
    [Google Scholar]
  25. ChimichiS. CoranS.A. ChimichiS. Bambagiotti-AlbertiM. GiannelliniV. BiddauB. Complete assignment of the 1h and 13c NMR spectra of secoisolariciresinol diglucoside, a mammalian lignan precursor isolated from linum usitatissimum complete assignment of the 1 h and 13 c nmr spectra of secoisolariciresinol diglucoside, a mammalian lignan precursor isolated from Linum usitatissimum.Magn. Reson. Chem.19993786086310.1002/(SICI)1097‑458X(199911)37:11<860::AID‑MRC559>3.0.CO;2‑A
    [Google Scholar]
  26. QiuS-X. LuZ-Z. LuyengiL. Isolation and characterization of flaxseed (Linum usitatissimum) constituents.Pharm. Biol.1999371710.1076/phbi.37.1.1.6320
    [Google Scholar]
  27. ThompsonL.U. BoucherB.A. LiuZ. CotterchioM. KreigerN. Phytoestrogen content of foods consumed in Canada, including isoflavones, lignans, and coumestan.Nutr. Cancer200654218420110.1207/s15327914nc5402_516898863
    [Google Scholar]
  28. Kamal-EldinA. PeerlkampN. JohnssonP. An oligomer from flaxseed composed of secoisolariciresinoldiglucoside and 3-hydroxy-3-methyl glutaric acid residues.Phytochemistry200158458759010.1016/S0031‑9422(01)00279‑511576603
    [Google Scholar]
  29. Bambagiotti-AlbertiM. CoronS.A. GhiaraC. MoretiG. RaffaelliA. TraldiP. Investigation of mammalian lignan precursors in flax seed: first evidence of secoisolariciresinol diglucoside in two isomeric forms by liquid chromatograph/mass spectrometry.Rapid Commun. Mass Spectrom.199481292993210.1002/rcm.12900812047696701
    [Google Scholar]
  30. EliassonC. Kamal-EldinA. AnderssonR. ÅmanP. High-performance liquid chromatographic analysis of secoisolariciresinol diglucoside and hydroxycinnamic acid glucosides in flaxseed by alkaline extraction.J. Chromatogr. A20031012215115910.1016/S0021‑9673(03)01136‑114521311
    [Google Scholar]
  31. SiciliaT. NiemeyerH.B. HonigD.M. MetzlerM. Identification and stereochemical characterization of lignans in flaxseed and pumpkin seeds.J. Agric. Food Chem.20035151181118810.1021/jf020797912590454
    [Google Scholar]
  32. MeagherL.P. BeecherG.R. FlanaganV.P. LiB.W. Isolation and characterization of the lignans, isolariciresinol and pinoresinol, in flaxseed meal.J. Agric. Food Chem.19994783173318010.1021/jf981359y10552626
    [Google Scholar]
  33. MazurW.M. UeharaM. WähäläK. AdlercreutzH. Phyto-oestrogen content of berries, and plasma concentrations and urinary excretion of enterolactone after a single strawberry-meal in human subjects.Br. J. Nutr.200083438138710858696
    [Google Scholar]
  34. BartkieneE. SkabeikyteE. KrungleviciuteV. The influence of fermentation on the content of alkylresorcinols and lignans in plant products.Open Biotechnol. J.20159313810.2174/1874070701509010031
    [Google Scholar]
  35. TouréA. XuemingX. Flaxseed lignans: source, biosynthesis, metabolism, antioxidant activity, bio-active components, and health benefits.Compr. Rev. Food Sci. Food Saf.20109326126910.1111/j.1541‑4337.2009.00105.x33467817
    [Google Scholar]
  36. FukumitsuS. AidaK. ShimizuH. ToyodaK. Flaxseed lignan lowers blood cholesterol and decreases liver disease risk factors in moderately hypercholesterolemic men.Nutr. Res.201030744144610.1016/j.nutres.2010.06.00420797475
    [Google Scholar]
  37. PrasadK. Hydroxyl radical-scavenging property of secoisolariciresinol diglucoside (SDG) isolated from flax-seed.Mol. Cell. Biochem.19971681-211712310.1023/A:10068473107419062900
    [Google Scholar]
  38. PrasadK. Antioxidant activity of secoisolariciresinol diglucoside-derived metabolites, secoisolariciresinol, enterodiol, and enterolactone.Int. J. Angiol.20009422022510.1007/BF0162389811062311
    [Google Scholar]
  39. AdolpheJ.L. WhitingS.J. JuurlinkB.H.J. ThorpeL.U. AlcornJ. Health effects with consumption of the flax lignan secoisolariciresinol diglucoside.Br. J. Nutr.2010103792993810.1017/S000711450999275320003621
    [Google Scholar]
  40. ThompsonL.U. RickardS.E. OrchesonL.J. SeidlM.M. Flaxseed and its lignan and oil components reduce mammary tumor growth at a late stage of carcinogenesis.Carcinogenesis19961761373137610.1093/carcin/17.6.13738681458
    [Google Scholar]
  41. SokD-E. CuiH.S. KimM.R. Isolation and bioactivities of furfuran type lignan compounds from edible plants.Recent Pat. Food Nutr. Agric.200911879510.2174/221279841090101008720653530
    [Google Scholar]
  42. WestcottN. MuirA. Chemical Studies on the Constituents of Linum Spp. Flax the genus Linum.New YorkTaylor and Francis20035573
    [Google Scholar]
  43. SchweigererL. ChristeleitK. FleischmannG. Identification in human urine of a natural growth inhibitor for cells derived from solid paediatric tumours.Eur. J. Clin. Invest.199222426026410.1111/j.1365‑2362.1992.tb01460.x1499641
    [Google Scholar]
  44. SturgeonS.R. HeersinkJ.L. VolpeS.L. Effect of dietary flaxseed on serum levels of estrogens and androgens in postmenopausal women.Nutr. Cancer200860561261810.1080/0163558080197186418791924
    [Google Scholar]
  45. AdlercreutzH. BannwartC. WähäläK. Inhibition of human aromatase by mammalian lignans and isoflavonoid phytoestrogens.J. Steroid Biochem. Mol. Biol.199344214715310.1016/0960‑0760(93)90022‑O8382517
    [Google Scholar]
  46. WangC. MäkeläT. HaseT. AdlercreutzH. KurzerM.S. Lignans and flavonoids inhibit aromatase enzyme in human preadipocytes.J. Steroid Biochem. Mol. Biol.1994503-420521210.1016/0960‑0760(94)90030‑28049151
    [Google Scholar]
  47. HutchinsA. SlavinJ. Effects of flaxseed on sex hormone metabolism.Flaxseed Hum Nutr2003812614910.1201/9781439831915.ch6
    [Google Scholar]
  48. SinghK. JhambS. KumarR. Effect of pretreatments on performance of screw pressing for flaxseed.J. Food Process Eng.20123554355610.1111/j.1745‑4530.2010.00606.x
    [Google Scholar]
  49. EdelA.L. AlianiM. PierceG.N. Stability of bioactives in flaxseed and flaxseed-fortified foods.Food Res. Int.20157714015510.1016/j.foodres.2015.07.035
    [Google Scholar]
  50. OomahB.D. MazzaG. Flaxseed proteins-A review.Food Chem.19934810911410.1016/0308‑8146(93)90043‑F
    [Google Scholar]
  51. MazzaG. BiliaderisC. Functional properties of flax seed mucilage.J. Food Sci.1989541302130510.1111/j.1365‑2621.1989.tb05978.x
    [Google Scholar]
  52. KaewmaneeT. BagnascoL. BenjakulS. Characterisation of mucilages extracted from seven Italian cultivars of flax.Food Chem.2014148606910.1016/j.foodchem.2013.10.02224262527
    [Google Scholar]
  53. QianK.Y. CuiS.W. WuY. GoffH.D. Flaxseed gum from flaxseed hulls: Extraction, fractionation, and characterization.Food Hydrocoll.20122827528310.1016/j.foodhyd.2011.12.019
    [Google Scholar]
  54. CuiW. MazzaG. BiliaderisC.G. Chemical structure, molecular size distributions, and rheological properties of flaxseed gum.J. Agric. Food Chem.1994421891189510.1021/jf00045a012
    [Google Scholar]
  55. ReboléA. RodríguezM.L. OrtizL.T. AlzuetaC. CentenoC. TreviñoJ. Mucilage in Linseed: Effects on the intestinal viscosity and nutrient digestion in broiler chicks.J. Sci. Food Agric.2002821171117610.1002/jsfa.1164
    [Google Scholar]
  56. WheltonS.P. HyreA.D. PedersenB. YiY. WheltonP.K. HeJ. Effect of dietary fiber intake on blood pressure: A meta-analysis of randomized, controlled clinical trials.J. Hypertens.200523347548110.1097/01.hjh.0000160199.51158.cf15716684
    [Google Scholar]
  57. KapoorS. SachdevaR. KochharA. Flaxseed: A potential treatment of lowering blood glucose and lipid profile among diabetic females.Indian J. Nutr. Diet.201148529536
    [Google Scholar]
  58. FerranniniE. BuzzigoliG. BonadonnaR. Insulin resistance in essential hypertension.N. Engl. J. Med.1987317635035710.1056/NEJM1987080631706053299096
    [Google Scholar]
  59. ReavenG.M. Insulin resistance/compensatory hyperinsulinemia, essential hypertension, and cardiovascular disease.J. Clin. Endocrinol. Metab.20038862399240310.1210/jc.2003‑03008712788834
    [Google Scholar]
  60. FodjeA.M.L. ChangP.R. LetermeP. In vitro bile acid binding and short-chain fatty acid profile of flax fiber and ethanol co-products.J. Med. Food20091251065107310.1089/jmf.2008.024219857071
    [Google Scholar]
  61. TheuwissenE. MensinkR.P. Water-soluble dietary fibers and cardiovascular disease.Physiol. Behav.200894228529210.1016/j.physbeh.2008.01.00118302966
    [Google Scholar]
  62. YeZ. ArumugamV. HaugabrooksE. WilliamsonP. HendrichS. Soluble dietary fiber (Fibersol-2) decreased hunger and increased satiety hormones in humans when ingested with a meal.Nutr. Res.201535539340010.1016/j.nutres.2015.03.00425823991
    [Google Scholar]
  63. LinH.V. FrassettoA. KowalikE.J.Jr Butyrate and propionate protect against diet-induced obesity and regulate gut hormones via free fatty acid receptor 3-independent mechanisms.PLoS One201274e3524010.1371/journal.pone.003524022506074
    [Google Scholar]
  64. RemelyM. AumuellerE. MeroldC. Effects of short chain fatty acid producing bacteria on epigenetic regulation of FFAR3 in type 2 diabetes and obesity.Gene20145371859210.1016/j.gene.2013.11.08124325907
    [Google Scholar]
  65. DuH van der ADL BoshuizenHC Dietary fiber and subsequent changes in body weight and waist circumference in European men and women.Am. J. Clin. Nutr.201091232933610.3945/ajcn.2009.2819120016015
    [Google Scholar]
  66. BurrG.O. BurrM.M. On the nature and role of the fatty acids essential in nutrition.J. Biol. Chem.19308658762110.1016/S0021‑9258(20)78929‑5
    [Google Scholar]
  67. De LorgerilM. SalenP. LaporteF. De LeirisJ. Alpha-linolenic acid in the prevention and treatment of coronary heart disease.Eur. Heart J. Suppl.20013263210.1016/S1520‑765X(01)90115‑4
    [Google Scholar]
  68. HurteauM-C. Unique new food products contain good omega fats.J. Food Sci. Educ.20063525310.1111/j.1541‑4329.2004.tb00044.x
    [Google Scholar]
  69. ArendW.P. DayerJ-M. Inhibition of the production and effects of interleukin-1 and tumor necrosis factor α in rheumatoid arthritis.Arthritis Rheum.199538215116010.1002/art.17803802027848304
    [Google Scholar]
  70. KremerJ.M. n-3 fatty acid supplements in rheumatoid arthritis.Am. J. Clin. Nutr.2000711Suppl.349S351S10.1093/ajcn/71.1.349s10617995
    [Google Scholar]
  71. OrchesonL.J. RickardS.E. SeidlM.M. ThompsonL.U. Flaxseed and its mammalian lignan precursor cause a lengthening or cessation of estrous cycling in rats.Cancer Lett.19981251-2697610.1016/S0304‑3835(97)00482‑59566698
    [Google Scholar]
  72. GonzalezM.J. SchemmelR.A. GrayJ.I. DuganL.Jr SheffieldL.G. WelschC.W. Effect of dietary fat on growth of MCF-7 and MDA-MB231 human breast carcinomas in athymic nude mice: relationship between carcinoma growth and lipid peroxidation product levels.Carcinogenesis19911271231123510.1093/carcin/12.7.12312070488
    [Google Scholar]
  73. GaborH. AbrahamS. Effect of dietary menhaden oil on tumor cell loss and the accumulation of mass of a transplantable mammary adenocarcinoma in BALB/c mice.J. Natl. Cancer Inst.1986766122312293458958
    [Google Scholar]
  74. RidgesL. SunderlandR. MoermanK. MeyerB. AstheimerL. HoweP. Cholesterol lowering benefits of soy and linseed enriched foods.Asia Pac. J. Clin. Nutr.200110320421110.1046/j.1440‑6047.2001.00253.x11708310
    [Google Scholar]
  75. BhathenaS.J. AliA.A. HaudenschildC. Dietary flaxseed meal is more protective than soy protein concentrate against hypertriglyceridemia and steatosis of the liver in an animal model of obesity.J. Am. Coll. Nutr.200322215716410.1080/07315724.2003.1071928912672712
    [Google Scholar]
  76. TiemeierH. van TuijlH.R. HofmanA. KiliaanA.J. BretelerM.M.B. Plasma fatty acid composition and depression are associated in the elderly: the Rotterdam Study.Am. J. Clin. Nutr.2003781404610.1093/ajcn/78.1.4012816769
    [Google Scholar]
  77. LockeC StollA. Omega-3 Fatty Acids in Major Depression.Nutrition and Fitness: Diet, Genes, Physical Activity and Health.Basel: Karger2001Vol. 8917318510.1159/000059784
    [Google Scholar]
  78. MadhusudhanK.T. SinghN. Isolation and characterization of the major fraction (12 S) of linseed proteins.J. Agric. Food Chem.19853367367710.1021/jf00064a026
    [Google Scholar]
  79. ChungM.W.Y. LeiB. Li-ChanE.C.Y. Isolation and structural characterization of the major protein fraction from norman flaxseed (Linum usitatissimum L.).Food Chem.20059027127910.1016/j.foodchem.2003.07.038
    [Google Scholar]
  80. OomahB.D. Flaxseed as a functional food source.J. Sci. Food Agric.20018188989410.1002/jsfa.898
    [Google Scholar]
  81. BhathenaS.J. AliA.A. MohamedA.I. HansenC.T. VelasquezM.T. Differential effects of dietary flaxseed protein and soy protein on plasma triglyceride and uric acid levels in animal models.J. Nutr. Biochem.2002131168468910.1016/S0955‑2863(02)00227‑912550066
    [Google Scholar]
  82. XuY. HallC.III Wolf-HallC. Antifungal activity stability of flaxseed protein extract using response surface methodology.J. Food Sci.2008731M9M1410.1111/j.1750‑3841.2007.00576.x18211360
    [Google Scholar]
  83. KapoorL. Handbook of Ayurvedic Medicinal Plants.LondonCRC Press2005
    [Google Scholar]
  84. BernacchiaR. PretiR. VinciG. Chemical composition and health benefits of flaxseed.Austin J. Nutr. Food Sci.2014210451051
    [Google Scholar]
  85. WinterR. Vitamin E: Your protection against exercise fatigue, weakened immunity, heart disease, cancer, aging, diabetic damage, environmental toxins.New YorkThree Rivers Press2013
    [Google Scholar]
  86. MeagherE.A. BarryO.P. LawsonJ.A. RokachJ. FitzGeraldG.A. Effects of vitamin E on lipid peroxidation in healthy persons.JAMA200128591178118210.1001/jama.285.9.117811231747
    [Google Scholar]
  87. GoyalA. SharmaV. UpadhyayN. GillS. SihagM. Flax and flaxseed oil: an ancient medicine & modern functional food.J. Food Sci. Technol.20145191633165310.1007/s13197‑013‑1247‑925190822
    [Google Scholar]
  88. ThompsonL.U. CunnaneS.C. Flaxseed in Human Nutrition.2nd edNew YorkAOCS Publishing200310.1201/9781003040378
    [Google Scholar]
  89. JoshiK. LadS. KaleM. Supplementation with flax oil and vitamin C improves the outcome of Attention Deficit Hyperactivity Disorder (ADHD).Prostaglandins Leukot. Essent. Fatty Acids2006741172110.1016/j.plefa.2005.10.00116314082
    [Google Scholar]
  90. CoulmanK.D. LiuZ. MichaelidesJ. Quan HumW. ThompsonL.U. Fatty acids and lignans in unground whole flaxseed and sesame seed are bioavailable but have minimal antioxidant and lipid-lowering effects in postmenopausal women.Mol. Nutr. Food Res.200953111366137510.1002/mnfr.20090003219824016
    [Google Scholar]
  91. KhalesiS. IrwinC. SchubertM. Flaxseed consumption may reduce blood pressure: a systematic review and meta-analysis of controlled trials.J. Nutr.2015145475876510.3945/jn.114.20530225740909
    [Google Scholar]
  92. McKieR. LoVecchioF. Complications of supplements and herbal medications.Prim Care Reports201319145154
    [Google Scholar]
  93. WanasundaraP. ShahidiF. Removal of flaxseed mucilage by chemical and enzymatic treatments.Food Chem.199759475510.1016/S0308‑8146(96)00093‑3
    [Google Scholar]
  94. KaithwasG. MukherjeeA. ChaurasiaA.K. MajumdarD.K. Anti-inflammatory, analgesic and antipyretic activities of Linum usitatissimum L. (flaxseed/linseed) fixed oil.Indian J. Exp. Biol.2011491293293822403867
    [Google Scholar]
  95. Demark-WahnefriedW. PriceD.T. PolascikT.J. Pilot study of dietary fat restriction and flaxseed supplementation in men with prostate cancer before surgery: exploring the effects on hormonal levels, prostate-specific antigen, and histopathologic features.Urology2001581475210.1016/S0090‑4295(01)01014‑711445478
    [Google Scholar]
  96. ChenJ. SaggarJ.K. CoreyP. ThompsonL.U. Flaxseed cotyledon fraction reduces tumour growth and sensitises tamoxifen treatment of human breast cancer xenograft (MCF-7) in athymic mice.Br. J. Nutr.2011105333934710.1017/S000711451000355721138602
    [Google Scholar]
  97. SerrainoM. ThompsonL.U. The effect of flaxseed supplementation on early risk markers for mammary carcinogenesis.Cancer Lett.199160213514210.1016/0304‑3835(91)90220‑C1657368
    [Google Scholar]
  98. RathB.P. PradhanD. Antidepressant activity of linum usitatissimum extract.Int J Pharmacogn Phytochem Res201212932
    [Google Scholar]
  99. GhuleA.E. JadhavS.S. BodhankarS.L. Effect of ethanolic extract of seeds of Linum usitatissimum (Linn.) in hyperglycaemia associated ros production in pbmncs and pancreatic tissue of alloxan induced diabetic rats.Asian Pac. J. Trop. Dis.2012240541010.1016/S2222‑1808(12)60088‑7
    [Google Scholar]
  100. AminT. ThakurM. A comparative study on proximate composition, phytochemical screening, antioxidant and antimicrobial activities of Linum usitatisimum L. (Flaxseeds).Int. J. Curr. Microbiol. Appl. Sci.20143465481
    [Google Scholar]
  101. ZanwarA. HegdeM. BodhankarS. In vitro antioxidant activity of ethanolic extract of Linum usitatissimum.Pharmacol20101683696
    [Google Scholar]
  102. DuganiA. AuzziA. NaasF. MegwezS. Effects of the oil and mucilage from flaxseed (Linum usitatissimum) on gastric lesions induced by ethanol in rats.Libyan J. Med.20083416616910.3402/ljm.v3i4.478721503150
    [Google Scholar]
  103. Hanif PallaA. GilaniA.H. Dual effectiveness of Flaxseed in constipation and diarrhea: Possible mechanism.J. Ethnopharmacol.2015169606810.1016/j.jep.2015.03.06425889554
    [Google Scholar]
  104. WardW.E. YuanY.V. CheungA.M. ThompsonL.U. Exposure to purified lignan from flaxseed (Linum usitatissimum) alters bone development in female rats.Br. J. Nutr.200186449950510.1079/BJN200142911591237
    [Google Scholar]
  105. BeroualK. HalmiS. MaameriZ. Pharmacological aspect of Linum usitatissimum: Flax ingestion on hair growth in rabbits.J Nat Prod Plant Resour2014447
    [Google Scholar]
  106. PrasadK. Reduction of serum cholesterol and hypercholesterolemic atherosclerosis in rabbits by secoisolariciresinol diglucoside isolated from flaxseed.Circulation199999101355136210.1161/01.CIR.99.10.135510077521
    [Google Scholar]
  107. FernandesF.S. de SouzaA.S. do Carmo Md, Boaventura GT. Maternal intake of flaxseed-based diet (Linum usitatissimum) on hippocampus fatty acid profile: implications for growth, locomotor activity and spatial memory.Nutrition201127101040104710.1016/j.nut.2010.11.00121439792
    [Google Scholar]
  108. AvelinoA.P.A. OliveiraG.M.M. FerreiraC.C.D. LuizR.R. RosaG. Additive effect of linseed oil supplementation on the lipid profiles of older adults.Clin. Interv. Aging2015101679168526543357
    [Google Scholar]
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