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image of Amelioration of D-Galactose-induced Renal Injury by a Functional Food Mix through AGE/RAGE/NF-κB Dependent Mechanism in a Rat Model

Abstract

Background

Ageing entails a gradual decline of organ structure and function, including the kidneys. Chronic kidney disease is associated with cardiovascular complications, hyperlipidemia, and metabolic bone disease. Functional foods with antioxidant, anti-inflammatory, and anti-apoptotic properties protect kidney functions by influencing metabolism and immunity.

Objective

We studied the prophylactic effect of a functional food mix [amla, cinnamon, ginger, turmeric, and black pepper] on D-galactose-induced renal ageing.

Methods

Six-month-old female Wistar rats were divided into Control, D-galactose, and D-galactose + functional food groups and maintained for 90 days. The plasma lipid profile and renal function tests were assayed using spectrophotometry. The protein markers of the endoplasmic reticulum [ER] stress, inflammation, and apoptosis were analysed by immunoblotting.

Results

The results illustrate that the functional food prevented D-galactose-induced histological alterations, dyslipidemia, podocin loss, renal dysfunction, ER stress [GRP78, pIRE1, and CHOP], inflammation [NF-κB, and TNFα], and apoptosis [Bax, and caspase-3] in the kidney.

Conclusion

The antiglycation, antioxidant, and anti-inflammatory roles of functional food are the basis for preventing D-galactose-induced renal injury. Hence, it could be a prophylactic measure in individuals with chronic kidney disease.

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2024-11-11
2025-01-24

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/content/journals/cff/10.2174/0126668629328687240926050822
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Amelioration of D-Galactose-induced Renal Injury by a Functional Food Mix through AGE/RAGE/NF-κB Dependent Mechanism in a Rat Model
Bentham Science Publishers ; https://doi.org/10.2174/0126668629328687240926050822
/content/journals/cff/10.2174/0126668629328687240926050822
/content/journals/cff/10.2174/0126668629328687240926050822
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  • Article Type:     Research Article
Keywords: inflammation ; anti-ageing ; advanced glycosylation end-products ; renal ageing ; Chronic kidney disease ; kidney dysfunction ; endoplasmic reticulum stress

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