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2000
Volume 3, Issue 3
  • ISSN: 2666-8629
  • E-ISSN: 2666-8637

Abstract

Background

Ageing entails a gradual decline of organ structure and function, including the kidneys. Chronic kidney disease is associated with cardiovascular complications, hyperlipidemia, and metabolic bone disease. Functional foods with antioxidant, anti-inflammatory, and anti-apoptotic properties protect kidney functions by influencing metabolism and immunity.

Objective

We studied the prophylactic effect of a functional food mix (amla, cinnamon, ginger, turmeric, and black pepper) on D-galactose-induced renal ageing.

Methods

Six-month-old female Wistar rats were divided into Control, D-galactose, and D-galactose + functional food groups and maintained for 90 days. The plasma lipid profile and renal function tests were assayed using spectrophotometry. The protein markers of the endoplasmic reticulum (ER) stress, inflammation, and apoptosis were analysed by immunoblotting.

Results

The results illustrate that the functional food prevented D-galactose-induced histological alterations, dyslipidemia, podocin loss, renal dysfunction, ER stress (GRP78, pIRE1, and CHOP), inflammation (NF-κB, and TNFα), and apoptosis (Bax, and caspase-3) in the kidney.

Conclusion

The antiglycation, antioxidant, and anti-inflammatory roles of functional food are the basis for preventing D-galactose-induced renal injury. Hence, it could be a prophylactic measure in individuals with chronic kidney disease.

© 2025 Bentham Science Publishers
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2024-11-11
2026-02-19

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Amelioration of D-Galactose-induced Renal Injury by a Functional Food Mix through AGE/RAGE/NF-κB Dependent Mechanism in a Rat Model
Curr Func Foods 3, E26668629328687 (2025); https://doi.org/10.2174/0126668629328687240926050822
/content/journals/cff/10.2174/0126668629328687240926050822
/content/journals/cff/10.2174/0126668629328687240926050822
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  • Article Type:     Research Article
Keyword(s): advanced glycosylation end-products; anti-ageing; Chronic kidney disease; endoplasmic reticulum stress; inflammation; kidney dysfunction; renal ageing

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