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image of Boon Plant Calendula Officinalis Linn. (CO): An Investigation, Ethnopharmacological, Phytoconstituent Review’

Abstract

Introduction

Calendula (English Marigold), or “Pot Marigold,” is a well-known herbal plant from the family of Asteraceae, which has been used for thousands of years as a medicinal herb. It is one of the most widely used aromatic herbs in the Ayurvedic system of medicine, which is based on the ethnological significance of the plant. Extracts of this plant have been found to possess a range of therapeutic benefits, including anti-hyperlipidaemia, cardiovascular and antidiabetic properties, as well as antioxidant and anti-inflammatory properties. Additionally, it has been found to be effective in wound healing and has anti-cancer, anti-hepatitis, antibacterial, and antiretroviral properties. Traditionally, it has been used as a herbal remedy to treat skin tumours and dermatological lesions as well as ulcers and swellings, as well as nervous disorders.

Aims

In addition to ethnopharmacology, pharmacology, and toxicology, this abstract also covers the morphology, microscopy, phytoconstituents, pharmacological reports, phytochemistry, and toxicity of the well-known Calendula species. Cosmetic ingredients derived from the C officinalis plant include extracts, flower oil, seed oil, and other components of the plant. These components include minerals, carbohydrates, and lipids; phenolic acids; flavonoids; tannins; coumarins; sterols; steroids; monoterpenes; sesquiterpene; triterpenes; tocopherol; quinones; amino acids; and resins. A chemical analysis of these ingredients reveals a wide variety of chemical compounds, including amino acid, triterpenoid, quinone, flavonoid, volatile oil, carotenoid, and other chemicals. Some Calendula officinalis species have medicinal value, and a literature review highlights their utilization.

Results

Calendula officinalis has a wide range of medicinal properties, ranging from antibacterial and antifungal properties to anthelmintic and antiviral properties. Additionally, it has antioxidant and hepatoprotective properties, as well as cardioprotective and wound-healing properties. Furthermore, it has been used to treat gastrointestinal, eye, and skin diseases. The plant has the potential to be a significant medicinal resource for mankind. It exhibits anti-HIV, cytotoxic, anti-inflammatory, hepatoprotective, and spasmolytic properties. The plant is used in almost 200 cosmetic formulations and has the potential for further research.

Conclusion

This review emphasizes the future scope of Calendula species, focusing on their multifarious biological activities and potential applications as medicinal agents. This research fills gaps in existing studies, allowing researchers to validate traditional claims and advance the safe and effective use of CO in treating various ailments.

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2024-10-23
2024-11-26
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References

  1. Agrawal O.P. Raju P.S. Global market of herbal products: Opportunities for Indian Traditional System of Medicine. New Delhi, India Narcosa Publishing House 2006 5 10
    [Google Scholar]
  2. Basu B.D. Indian Medicinal Plants. Dehradun, India International Book Distributor 1993 Vol. II 1413 1414
    [Google Scholar]
  3. The Wealth of India Raw Materials, A Dictionary of Indian Raw Material & Industrial Products. New Delhi Publications & Information Directorate CSIR 1992 3 55 58
    [Google Scholar]
  4. Ashwlayan V.D. Kumar A. Verma M. Garg V.K. Gupta S.K. Therapeutic potential of calendula officinalis. Pharm. Pharmacol. Int. J. 2018 6 2 149155 10.15406/ppij.2018.06.00171
    [Google Scholar]
  5. Wikipedia Calendula officinalis. 2009 Available From: http://en.wikipedia.org/wiki/Calendula_officinalis
  6. Editorial Boards PDR for Herbal Medicines. 2nd ed Montvale Thomson-Medical Economics 2003 497 500
    [Google Scholar]
  7. Mani A. Pawar B. Marawar Sharma A. Rani A. Arora D. A review on phytochemistry and ethnopharmacological aspects of genus Calendula. Pharmacogn. Rev. 2013 7 14 179 87 10.4103/0973‑7847.120520
    [Google Scholar]
  8. Khairnar M.S. Evaluation of Calendula officinalis as an anti-plaque and anti-gingivitis agent. J Indian Soc Periodontol. 2013 17 6 741 747 10.4103/0972‑124X.124491
    [Google Scholar]
  9. Basu B.D. Indian Medicinal Plants. Dehradun, India International Book Distributor 1993 Vol. II 1413 1414
    [Google Scholar]
  10. Al-Snafi AE Calendula officinalis's chemical components and pharmacological effects: A review. Indian J. Pharmaceut. Sci. Res. 2015 5 3 172 85
    [Google Scholar]
  11. Arora D. Rani A. Sharma A. an overview of the ethnopharmacology and phytochemistry of the genus Calendula. Pharmacogn. Rev. 2013 7 14 179 10.4103/0973‑7847.120520 24347926
    [Google Scholar]
  12. Samochowiec L. Pharmacological study of saponifies from Aralia manshurica rupr.et maxim. and Calendula officinalis. L Herbal Pol. 1983 29 151 155
    [Google Scholar]
  13. Iauk L. Lo Bue A.M. Milazzo I. Rapisarda A. Blandino G. Antibacterial activity of medicinal plant extracts against periodontopathic bacteria. Phytother. Res. 2003 17 6 599 604 10.1002/ptr.1188 12820224
    [Google Scholar]
  14. Gazim Z.C. Rezende C.M. Fraga S.R. Svidzinski T.I.E. Cortez D.A.G. Antifungal activity of the essential oil from Calendula officinalis L. (asteraceae) growing in Brazil. Braz. J. Microbiol. 2008 39 1 61 63 10.1590/S1517‑83822008000100015 24031180
    [Google Scholar]
  15. Preethi KC Kuttan G Kuttan R Antioxidant potential of an extract of calendula officinalis. flowers in vitro. and in vivo. Pharmaceut. Biol. 2006 44 9 691 697
    [Google Scholar]
  16. Hussein MS El-Tawil OS El-Hoda Yassin N Abdou KA The study investigates the protective effect of Morus alba and calendula officinalis plant extracts on carbon tetrachloride-induced hepatotoxicity in isolated rat hepatocytes. J. American Sci 2010 6 10 762 73
    [Google Scholar]
  17. Chakraborty G.S. Arora R. Majee C. Anti-diabetic and Anti-hyperlipidaemic Effect of Hydroalcoholic extract of Calendula officinalis. Int ResJ Pharm. 2011 2 1 61 65
    [Google Scholar]
  18. Al-Snafi A.E. The chemical constituents and pharmacological effects of calendula officinalis -a review. Indian J. Pharmaceut. Sci. Res. 2015 5 3 172 185
    [Google Scholar]
  19. Purwal L. Shrivastav V. Makonde K.K. Jain U. Anthelmintic activity of aqueous extracts of some Saponin containing medicinal plants. Pharm. Lett. 2010 2 4 476 481
    [Google Scholar]
  20. Kalvatchev Z. Walder R. Garzaro D. Anti-HIV activity of extracts from Calendula officinalis flowers. Biomed. Pharmacother. 1997 51 4 176 180 10.1016/S0753‑3322(97)85587‑4 9207986
    [Google Scholar]
  21. Beudot C. De Méo M.P. Dauzonne D. Elias R. Laget M. Guiraud H. Balansard G. Duménil G. Evaluation of the mutagenicity and antimutagenicity of forty-two 3-substituted flavones in the Ames test. Mutat. Res. Genet. Toxicol. Environ. Mutagen. 1998 417 2-3 141 153 10.1016/S1383‑5718(98)00103‑X 9733954
    [Google Scholar]
  22. Chandran P.K. Kuttan R. Effect of Calendula officinalis flower extract on acute phase proteins, antioxidant defence mechanism and granuloma formation during thermal burns. J. Clin. Biochem. Nutr. 2008 43 2 58 64 10.3164/jcbn.2008043 18818737
    [Google Scholar]
  23. Alexenizer M. Dorn A. Screening of medicinal and ornamental plants for insecticidal and growth regulating activity. J. Pest Sci. 2007 80 4 205 215 10.1007/s10340‑007‑0173‑x
    [Google Scholar]
  24. Pérez-Gutiérrez S. Vargas-Solís R. Zavala S M. Pérez-G C. Pérez-G R.M. Inhibitory effect of five plant extracts on heart rates of rats. Phytother. Res. 1998 12 S1 S49 S50 10.1002/(SICI)1099‑1573(1998)12:1+<S49::AID‑PTR248>3.0.CO;2‑B
    [Google Scholar]
  25. Bogdanova N.S. Nikolaeva I.S. Shcherbakova L.I. Tolstova T.I. Moskalenko N.Iu. Pershin G.N. [Study of antiviral properties of Calendula officinalis]. Farmakol. Toksikol. 1970 33 3 349 355 4318166
    [Google Scholar]
  26. Khare C.P. Encyclopaedia of Indian Medicinal Plants. Germany Springer-Verlag Publisher 2004 116 117
    [Google Scholar]
  27. Ćetković G.S. Djilas S.M. Čanadanović-Brunet J.M. Tumbas V.T. Antioxidant properties of marigold extracts. Food Res. Int. 2004 37 7 643 650 10.1016/j.foodres.2004.01.010
    [Google Scholar]
  28. John R. Jan N. John R. Calendula officinalis-an important medicinal plant with potential biological properties. Proc. Indian Natl. Sci. Acad. A Phys. Sci. 2017 93 0 769 787 10.16943/ptinsa/2017/49126
    [Google Scholar]
  29. Adela P. Bele C. Sanda A. Carmen S. Carotenoids in four Calendula officinalis L. flower types were analysed using HPLC. Acta Biol. Szeged. 2003 47 47 1 437
    [Google Scholar]
  30. Babaee N Moslemi D Anti-oxidant In patients with head and neck malignancies, the ability of Calendula officinalis flowers extract and prevention of radiation-induced oropharyngeal mucositis: A randomised controlled clinical study. Daru 2013 21 1 18 24 10.1186/2008‑2231‑21‑18 23497687
    [Google Scholar]
  31. Lima M Dos R Lopes AP Martins C Brito GAC Carneiro VC The Effect of Calendula officinalis on Oxidative Stress and Bone Loss in Experimental Periodontitis. Front. Physiol. 2017 8 00440 10.3389/fphys.2017.00440
    [Google Scholar]
  32. Saini P. Al-Shibani N. Sun J. Zhang W. Song F. Gregson K.S. Windsor L.J. Effects of Calendula officinalis on human gingival fibroblasts. Homeopathy 2012 101 2 92 98 10.1016/j.homp.2012.02.003 22487368
    [Google Scholar]
  33. Panahi Y. Sharif M.R. Sharif A. Beiraghdar F. Zahiri Z. Amirchoopani G. Marzony E.T. Sahebkar A. A randomized comparative trial on the therapeutic efficacy of topical aloe vera and Calendula officinalis on diaper dermatitis in children. ScientificWorldJournal 2012 2012 1 5 10.1100/2012/810234 22606064
    [Google Scholar]
  34. Pommier P. Gomez F. Sunyach M.P. D’Hombres A. Carrie C. Montbarbon X. Phase III randomized trial of Calendula officinalis compared with trolamine for the prevention of acute dermatitis during irradiation for breast cancer. J. Clin. Oncol. 2004 22 8 1447 1453 10.1200/JCO.2004.07.063 15084618
    [Google Scholar]
  35. Singh M. Bagewadi A. Comparison of effectiveness of Calendula officinalis extract gel with lycopene gel for treatment of tobacco-induced homogeneous leukoplakia: A randomized clinical trial. Int. J. Pharm. Investig. 2017 7 2 88 93 10.4103/jphi.JPHI_19_17 28929051
    [Google Scholar]
  36. Babaee N. Moslemi D. Khalilpour M. Vejdani F. Moghadamnia Y. Bijani A. Baradaran M. Kazemi M.T. Khalilpour A. Pouramir M. Moghadamnia A.A. Antioxidant capacity of calendula officinalis flowers extract and prevention of radiation induced oropharyngeal mucositis in patients with head and neck cancers: A randomized controlled clinical study. Daru 2013 21 1 18 10.1186/2008‑2231‑21‑18 23497687
    [Google Scholar]
  37. Giostri G.S. Novak E.M. Buzzi M. Guarita-Souza L.C. Treatment of acute wounds in hand with Calendula officinalis L.: A randomized trial. Tissue Barriers 2022 10 3 1994822 10.1080/21688370.2021.1994822 34674610
    [Google Scholar]
  38. Buzzi M. de Freitas F. de Barros Winter M. Therapeutic effectiveness of a Calendula officinalis extract in venous leg ulcer healing. J. Wound Care 2016 25 12 732 739 10.12968/jowc.2016.25.12.732 27974009
    [Google Scholar]
  39. De Angelis C. Di Stadio A. Vitale S. Saccone G. Angelis M.C.D. Zizolfi B. Di Spiezio Sardo A. Use of calendula ointment after episiotomy: A randomized clinical trial. J. Matern. Fetal Neonatal Med. 2022 35 10 1860 1864 10.1080/14767058.2020.1770219 32460565
    [Google Scholar]
  40. Saffari E. Mohammad-Alizadeh-Charandabi S. Adibpour M. Mirghafourvand M. Javadzadeh Y. Comparing the effects of Calendula officinalis and clotrimazole on vaginal Candidiasis : A randomized controlled trial. Women Health 2017 57 10 1145 1160 10.1080/03630242.2016.1263272 27880086
    [Google Scholar]
  41. Abedi P. Pazhohideh Z. Mohammadi S. Bahrami N. Mojab F. Maraghi E. The effect of Calendula officinalis versus metronidazole on bacterial vaginosis in women: A double-blind randomized controlled trial. J. Adv. Pharm. Technol. Res. 2018 9 1 15 19 10.4103/japtr.JAPTR_305_17 29441319
    [Google Scholar]
  42. Chandran P.K. Kuttan R. Effect of Calendula officinalis flower extract on acute phase proteins, anti-oxidant defense mechanism and granuloma formation during thermal burns. J. Clin. Biochem. Nutr. 2008 43 2 58 64 10.3164/jcbn.2008043 18818737
    [Google Scholar]
  43. Dinda M. Mazumdar S. Das S. Ganguly D. Dasgupta U.B. Dutta A. Jana K. Karmakar P. The water fraction of Calendula officinalis hydroethanol extract stimulates in vitro and in vivo proliferation of dermal fibroblasts in wound healing. Phytother. Res. 2016 30 10 1696 1707 10.1002/ptr.5678 27426257
    [Google Scholar]
  44. Fonseca Y.M. Catini C.D. Vicentini F.T.M.C. Nomizo A. Gerlach R.F. Fonseca M.J.V. Protective effect of Calendula officinalis extract against UVB-induced oxidative stress in skin: Evaluation of reduced glutathione levels and matrix metalloproteinase secretion. J. Ethnopharmacol. 2010 127 3 596 601 10.1016/j.jep.2009.12.019 20026397
    [Google Scholar]
  45. Parente L.M.L. Andrade M.A. Brito L.A.B. Moura V.M.B.D. Miguel M.P. Lino-Júnior R.S. Tresvenzol L.F.M. Paula J.R. Paulo N.M. Angiogenic activity of Calendula officinalis flowers L. in rats. Acta Cir. Bras. 2011 26 1 19 24 10.1590/S0102‑86502011000100005 21271199
    [Google Scholar]
  46. Parente LM Lino Junior Rde S Tresvenzol LM Vinaud MC de Paula JR Paulo NM Wound healing and anti-inflammatory effect in animal models of Calendula officinalis L. growing in Brazil. Evid Based Complement Alternat Med. 2012 2016 375671
    [Google Scholar]
  47. Preethi K.C. Kuttan R. Wound healing activity of flower extract of Calendula offlcinalis. J. Basic Clin. Physiol. Pharmacol. 2009 20 1 73 80 10.1515/JBCPP.2009.20.1.73 19601397
    [Google Scholar]
  48. Shafeie N. Tabatabai Naini A. Jahromi H. Comparison of different concentrations of calendula officinalis gel on cutaneous wound healing. Biomed. Pharmacol. J. 2015 8 2 979 992 10.13005/bpj/850
    [Google Scholar]
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