BackgroundSodium voltage-gated channel beta subunit 4 (SCN4B) plays a suppressive role in various tumors. However the role of SCN4B in non-small cell lung cancer (NSCLC) is not yet clear. This study aims to investigate the expression of SCN4B in NSCLC patients and its correlation with prognosis.MethodsFirstly the expression of SCN4B in non-small cell lung cancer (NSCLC) was analyzed using The Cancer Genome Atlas (TCGA) dat Read More

IntroductionCancer is one of the major causes of morbidity and mortality worldwide. Current treatments for both solid and hematological tumors are associated with severe adverse effects and drug resistance necessitating the development of novel selective antineoplastic drugs.MethodsThe present study describes the antitumor activity of the imidazacridine derivative 5-acridin-9-ylmethylidene-2-thioxoimidazolidin-4-one (LPSF/AC05) in breast cancer Read More

BackgroundSolid pediatric tumors refer to cancers that affect children and adolescents and they present unique challenges due to their distinct biological characteristics and their vulnerability to young patients. This study aims to shed light on addressing anemia and the causes of anemia in patients with solid pediatric tumors.Materials and MethodsThis retrospective cohort comprised 200 healthy children as controls and 235 patients with solid tumors. T Read More

BackgroundOne of the growing diseases in today's human societies is cancer which has become a major challenge especially in industrialized and developing countries. Cancer treatments are diverse but they usually use surgery chemotherapy and radiotherapy to improve patients. Existing drugs are usually expensive and in some cases are not effective due to drug resistance and side effects. Finding compounds of natural origin can be somewhat effe Read More

BackgroundThe development of new therapies targeting crucial kinases involved in cancer progression is a promising area of research. Pyrazolo pyrimidine derivatives have emerged as potential candidates for this purpose.ObjectiveThis study aims to synthesize pyrazolo pyrimidine derivatives (5a-5r) evaluate their molecular docking against key kinases and assess their anticancer activity.MethodsThe synthesis involved a multi-step procedure starting wit Read More

BackgroundSulfonamide derivatives are well-reported hCA IX inhibitors; however they inhibit all types of hCA without any selectivity leading to severe adverse effects. Hence developing a novel non-sulfonamide class of tumor-associated hCA IX inhibitors through non-classical inhibition may provide greater selectivity and better pharmacokinetics.ObjectiveThe objective of this study was to develop non-sulfonamide derivatives as potential human carbonic anhydr Read More

Breast cancer frequently occurs in women. Among the several types of breast cancers almost 50% of breast cancers are caused by one or more gene mutations of the PI3K/mTOR/AKT pathway. Capivasertib the first AKT inhibitor was authorized by the US FDA on November 16 2023. It is used for the treatment of adult patients with hormone receptor-positive human epidermal growth factor receptor 2 negative metastatic breast cancer with at l Read More

IntroductionTumor immunity has garnered increasing attention in cancer treatment and progression. However there is still a challenge in understanding the mechanisms of specific molecules affecting the clinical prognosis and tumor microenvironment (TME).MethodsHere we applied the ESTIMATE algorithm to calculate the immune and stromal scores in 504 HNSC cases from TCGA. Patients were grouped according to the median value of the immune an Read More

AimsInvestigating the impact of stemness-related circadian rhythm disruption (SCRD) on hepatocellular carcinoma (HCC) prognosis and its potential as a predictor for immunotherapy response.BackgroundCircadian disruption has been linked to tumor progression through its effect on the stemness of cancer cells.ObjectiveDevelop a novel signature for SCRD to accurately predict clinical outcomes and immune therapy response in patients with HCC.Met Read More

Radiotherapy (RT) is an integral part of treatment management in cancer patients. However one of the limitations of this treatment method is the resistance of cancer cells to radiotherapy. These restrictions necessitate the introduction of modalities for the radiosensitization of cancer cells. It has been shown that Noncoding RNAs (ncRNAs) along with modifiers can act as radiosensitivity and radioresistant regulators in a variety of cancers by affecting double Read More