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image of A Review of Anticancer Potential of Conferone, Diversin and Ferutinin; Which One is Stronger for Cancer Therapy?

Abstract

Background

One of the growing diseases in today's human societies is cancer, which has become a major challenge, especially in industrialized and developing countries. Cancer treatments are diverse, but they usually use surgery, chemotherapy, and radiotherapy to improve patients. Existing drugs are usually expensive and, in some cases, are not effective due to drug resistance and side effects. Finding compounds of natural origin can be somewhat effective and useful in helping doctors to treat this disease. plants, which are traditionally used as spices or for medicinal purposes, can be a good source for finding anti-cancer compounds due to their various compounds, such as monoterpenes, sulfide compounds, and polyphenols. Several studies have shown that compounds found in plants have significant anticancer effects on various types of cancer cells.

Objective

This article was compiled with the aim of collecting evidence and articles related to the anti-cancer effects of three compounds obtained from these plants, namely Conferone, Diversin, and Ferutinin.

Methods

This review article was prepared by searching the terms Conferone, Diversin, Ferutinin and cancer and related information was collected through searching electronic databases such as ISI Web of Knowledge, PubMed and Google Scholar until the March of 2024.

Conclusion

The results of this review showed that relatively comprehensive studies have been conducted in this field and these studies have shown that these compounds can be used in the design of future anticancer drugs. Among the examined compounds, conferone showed that it has the best effect on cancer cells.

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2024-10-30
2024-12-04
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References

  1. Mattiuzzi C. Lippi G. Current cancer epidemiology. J. Epidemiol. Glob. Health 2019 9 4 217 222 10.2991/jegh.k.191008.001 31854162
    [Google Scholar]
  2. Xia C. Dong X. Li H. Cao M. Sun D. He S. Yang F. Yan X. Zhang S. Li N. Chen W. Cancer statistics in China and United States, 2022: profiles, trends, and determinants. Chin. Med. J. 2022 135 5 584 590 10.1097/CM9.0000000000002108 35143424
    [Google Scholar]
  3. WHO. Diagnosis and treatment. Available from: https://www.who.int/publications/who-guidelines(accessed on 8-10-2024)
  4. Abbas Z. Rehman S. An overview of cancer treatment modalities. Neoplasm 2018 1 139 157
    [Google Scholar]
  5. Norouzi M. Amerian M. Amerian M. Atyabi F. Clinical applications of nanomedicine in cancer therapy. Drug Discov. Today 2020 25 1 107 125 10.1016/j.drudis.2019.09.017 31586642
    [Google Scholar]
  6. Maggiore U. Palmisano A. Buti S. Claire Giudice G. Cattaneo D. Giuliani N. Fiaccadori E. Gandolfini I. Cravedi P. Chemotherapy, targeted therapy and immunotherapy: Which drugs can be safely used in the solid organ transplant recipients? Transpl. Int. 2021 34 12 2442 2458 10.1111/tri.14115 34555228
    [Google Scholar]
  7. Thirumalaivasan N. Nangan S. Kanagaraj K. Rajendran S. Assessment of sustainability and environmental impacts of renewable energies: Focusing on biogas and biohydrogen (Biofuels) production. Process Saf. Environ. Prot. 2024 189 467 485 10.1016/j.psep.2024.06.063
    [Google Scholar]
  8. Shoker R.M.H. A review article: The importance of the major groups of plants secondary metabolism phenols, alkaloids, and terpenes. International Journal For Research in Applied Sciences and Biotechnology 2020 7 5 354 358 10.31033/ijrasb.7.5.47
    [Google Scholar]
  9. HemaIswarya S Doble M. Potential synergism of natural products in the treatment of cancer. Phyther Res An Int J Devoted to Pharmacol Toxicol Eval Nat Prod Deriv 2006 20 239 249
    [Google Scholar]
  10. Wang J. Ding R. Ouyang T. Gao H. Kan H. Li Y. Hu Q. Yang Y. Systematic investigation of the mechanism of herbal medicines for the treatment of prostate cancer. Aging (Albany NY) 2023 15 4 1004 1024 10.18632/aging.204516 36795572
    [Google Scholar]
  11. Baharara H. Rahsepar S. Emami S.A. Elyasi S. Mohammadpour A.H. Ghavami V. Rajendram R. Sahebkar A. Arasteh O. The efficacy of medicinal plant preparations in the alleviation of radiodermatitis in patients with breast cancer: A systematic review of clinical trials. Phytother. Res. 2023 37 8 3275 3295 10.1002/ptr.7894 37211432
    [Google Scholar]
  12. Kalachaveedu M. Senthil R. Azhagiyamanavalan S. Ravi R. Meenakshisundaram H. Dharmarajan A. Traditional medicine herbs as natural product matrices in cancer chemoprevention: A trans pharmacological perspective (scoping review). Phytother. Res. 2023 37 4 1539 1573 10.1002/ptr.7747 36788644
    [Google Scholar]
  13. Amiri M.S. Joharchi M.R. Ethnobotanical knowledge of Apiaceae family in Iran: A review. Avicenna J. Phytomed. 2016 6 6 621 635 28078243
    [Google Scholar]
  14. Christensen L.P. Brandt K. Bioactive polyacetylenes in food plants of the Apiaceae family: Occurrence, bioactivity and analysis. J. Pharm. Biomed. Anal. 2006 41 3 683 693 10.1016/j.jpba.2006.01.057 16520011
    [Google Scholar]
  15. Moran J. van Rijswijk B. Traicevski V. Kitajima E.W. Mackenzie A.M. Gibbs A.J. Potyviruses, novel and known, in cultivated and wild species of the family Apiaceae in Australia. Arch. Virol. 2002 147 10 1855 1867 10.1007/s00705‑002‑0865‑8 12376749
    [Google Scholar]
  16. Sirizi M.A.G. Alizadeh Ghalenoei J. Allahtavakoli M. Forouzanfar H. Bagheri S.M. Anticancer potential of Ferula assa-foetida and its constituents, a powerful plant for cancer therapy. World J. Biol. Chem. 2023 14 2 28 39 10.4331/wjbc.v14.i2.28 37034135
    [Google Scholar]
  17. Iranshahi M. Kalategi F. Rezaee R. Shahverdi A. Ito C. Furukawa H. Tokuda H. Itoigawa M. Cancer chemopreventive activity of terpenoid coumarins from Ferula species. Planta Med. 2008 74 2 147 150 10.1055/s‑2008‑1034293 18240102
    [Google Scholar]
  18. Ansari I.A. Akhtar M.S. Current insights on the role of terpenoids as anticancer agents: A perspective on cancer prevention and treatment. Natural Bio-active Compound Springer 2019 Vol. 2 53 80
    [Google Scholar]
  19. Neshati V. Matin M.M. Bahrami A.R. Iranshahi M. Rassouli F.B. Saeinasab M. Increasing the cisplatin cytotoxicity and cisplatin-induced DNA damage by conferone in 5637 cells. Nat. Prod. Res. 2012 26 18 1724 1727 10.1080/14786419.2011.606546 21988674
    [Google Scholar]
  20. Kasaian J. Mosaffa F. Behravan J. Masullo M. Piacente S. Iranshahi M. Modulation of multidrug resistance protein 2 efflux in the cisplatin resistance human ovarian carcinoma cells A2780/RCIS by sesquiterpene coumarins. Phytother. Res. 2016 30 1 84 89 10.1002/ptr.5504 26503061
    [Google Scholar]
  21. Khan S.S. Khan A. Marasini B.P. Saba N. Ahmad V.U. Iranshani M. Hosseini S.T. Choudhary M.I. (alpha)-Chymotrypsin and Urease Inhibitory Activity of Diversolides C, D and E from the Roots of Ferula Diversivittata. J. Chem. Soc. Pak. 2012 2012 34
    [Google Scholar]
  22. Luan L. Li N. Zhang K. Wang X. Pan H. Diversin upregulates the proliferative ability of colorectal cancer by inducing cell cycle proteins. Exp. Mol. Pathol. 2023 129 104850 10.1016/j.yexmp.2023.104850 36623636
    [Google Scholar]
  23. Naji Reyhani Garmroudi S. Karimi E. Oskoueian E. Homayouni-Tabrizi M. Iranshahi M. Ferutinin: A phytoestrogen from ferula and its anticancer, antioxidant, and toxicity properties. J. Biochem. Mol. Toxicol. 2021 35 4 e22713 10.1002/jbt.22713 33501774
    [Google Scholar]
  24. Junqueira M.Z. Chammas R. Cancer chemotherapy failure: A synthetic view. Rev. Med. 2018 97 2 141 153 10.11606/issn.1679‑9836.v97i2p141‑153
    [Google Scholar]
  25. Bach-Griera M. Campo-Pérez V. Barbosa S. Traserra S. Guallar-Garrido S. Moya-Andérico L. Herrero-Abadía P. Luquin M. Rabanal R.M. Torrents E. Julián E. Mycolicibacterium brumae is a safe and non-toxic immunomodulatory agent for cancer treatment. Vaccines 2020 8 2 198 10.3390/vaccines8020198 32344808
    [Google Scholar]
  26. Sauter E.R. Mohammed A. Natural products for cancer prevention and interception: Preclinical and clinical studies and funding opportunities. Pharmaceuticals 2024 17 1 136 10.3390/ph17010136 38276009
    [Google Scholar]
  27. Tewari D. Rawat P. Singh P.K. Adverse drug reactions of anticancer drugs derived from natural sources. Food Chem. Toxicol. 2019 123 522 535 10.1016/j.fct.2018.11.041 30471312
    [Google Scholar]
  28. Poustforoosh A. Faramarz S. Negahdaripour M. Tüzün B. Hashemipour H. Investigation on the mechanisms by which the herbal remedies induce anti-prostate cancer activity: uncovering the most practical natural compound. J. Biomol. Struct. Dyn. 2024 42 7 3349 3362 10.1080/07391102.2023.2213344 37194430
    [Google Scholar]
  29. Imtiaz I. Schloss J. Bugarcic A. Traditional and contemporary herbal medicines in management of cancer: A scoping review. J. Ayurveda Integr. Med. 2024 15 1 100904 10.1016/j.jaim.2024.100904 38395014
    [Google Scholar]
  30. Lin S.R. Chang C.H. Hsu C.F. Tsai M.J. Cheng H. Leong M.K. Sung P.J. Chen J.C. Weng C.F. Natural compounds as potential adjuvants to cancer therapy: Preclinical evidence. Br. J. Pharmacol. 2020 177 6 1409 1423 10.1111/bph.14816 31368509
    [Google Scholar]
  31. Lacey J. Huston A. Lopez G. Vozmediano J.R. Lam C.S. Narayanan S. Lu W. Wolf U. Subbiah I.M. Richard P. Lopez A.M. Rao S. Frenkel M. Establishing an Integrative Oncology Service: Essential Aspects of Program Development. Curr. Oncol. Rep. 2024 26 3 200 211 10.1007/s11912‑024‑01504‑x 38358637
    [Google Scholar]
  32. Muscolo A. Mariateresa O. Giulio T. Mariateresa R. Oxidative stress: the role of antioxidant phytochemicals in the prevention and treatment of diseases. Int. J. Mol. Sci. 2024 25 6 3264 10.3390/ijms25063264 38542238
    [Google Scholar]
  33. Khan F. Pandey P. Verma M. Ramniwas S. Lee D. Moon S. Park M.N. Upadhyay T.K. Kim B. Emerging trends of phytochemicals as ferroptosis modulators in cancer therapy. Biomed. Pharmacother. 2024 173 116363 10.1016/j.biopha.2024.116363 38479184
    [Google Scholar]
  34. Rafatpanah H. Golizadeh M. Mahdifar M. Mahdavi S. Iranshahi M. Rassouli F.B. Conferone, a coumarin from Ferula flabelliloba, induced toxic effects on adult T-cell leukemia/lymphoma cells. Int. J. Immunopathol. Pharmacol. 2023 37 03946320231197592 10.1177/03946320231197592 37688389
    [Google Scholar]
  35. Eruçar F.M. Kuran F.K. Altıparmak Ülbegi G. Özbey S. Karavuş Ş.N. Arcan G.G. Yazıcı Tütüniş S. Tan N. Aksoy Sağırlı P. Miski M. Sesquiterpene Coumarin Ethers with Selective Cytotoxic Activities from the Roots of Ferula huber-morathii Peşmen (Apiaceae) and Unequivocal Determination of the Absolute Stereochemistry of Samarcandin. Pharmaceuticals (Basel) 2023 16 6 792 10.3390/ph16060792 37375740
    [Google Scholar]
  36. Barthomeuf C. Demeule M. Grassi J. Saidkhodjaev A. Beliveau R. Conferone from Ferula schtschurowskiana enhances vinblastine cytotoxicity in MDCK-MDR1 cells by competitively inhibiting P-glycoprotein transport. Planta Med. 2006 72 7 634 639 10.1055/s‑2006‑931574 16739070
    [Google Scholar]
  37. Li S. Jiang M. Wang L. Yu S. Combined chemotherapy with cyclooxygenase-2 (COX-2) inhibitors in treating human cancers: Recent advancement. Biomed. Pharmacother. 2020 129 110389 10.1016/j.biopha.2020.110389 32540642
    [Google Scholar]
  38. Rahmani A. Rahimi F. Iranshahi M. Kahroba H. Zarebkohan A. Talebi M. Salehi R. Mousavi H.Z. Co-delivery of doxorubicin and conferone by novel pH-responsive β-cyclodextrin grafted micelles triggers apoptosis of metastatic human breast cancer cells. Sci. Rep. 2021 11 1 21425 10.1038/s41598‑021‑00954‑8 34728703
    [Google Scholar]
  39. Romani A.M.P. Cisplatin in cancer treatment. Biochem. Pharmacol. 2022 206 115323 10.1016/j.bcp.2022.115323 36368406
    [Google Scholar]
  40. Tchounwou P.B. Dasari S. Noubissi F.K. Ray P. Kumar S. Advances in our understanding of the molecular mechanisms of action of cisplatin in cancer therapy. J. Exp. Pharmacol. 2021 13 303 328 10.2147/JEP.S267383 33776489
    [Google Scholar]
  41. Song M. Cui M. Liu K. Therapeutic strategies to overcome cisplatin resistance in ovarian cancer. Eur. J. Med. Chem. 2022 232 114205 10.1016/j.ejmech.2022.114205 35217497
    [Google Scholar]
  42. Rahmani A. Zavvar Mousavi H. Salehi R. Bagheri A. Novel pH-sensitive and biodegradable micelles for the combined delivery of doxorubicin and conferone to induce apoptosis in MDA-MB-231 breast cancer cell line. RSC Advances 2020 10 49 29228 29246 10.1039/D0RA03467C 35521092
    [Google Scholar]
  43. Khalili L. Dehghan G. Hosseinpour Feizi M.A. Sheibani N. Hamishekar H. Development of an albumin decorated lipid-polymer hybrid nanoparticle for simultaneous delivery of methotrexate and conferone to cancer cells. Int. J. Pharm. 2021 599 120421 10.1016/j.ijpharm.2021.120421 33676992
    [Google Scholar]
  44. Chitsazian-Yazdi M. Agnolet S. Lorenz S. Schneider B. Es’haghi Z. Kasaian J. Khameneh B. Iranshahi M. Foetithiophenes C-F, thiophene derivatives from the roots of Ferula foetida. Pharm. Biol. 2015 53 5 710 714 10.3109/13880209.2014.939765 25430396
    [Google Scholar]
  45. Valiahdi S.M. Iranshahi M. Sahebkar A. Cytotoxic activities of phytochemicals from Ferula species. Daru 2013 21 1 39 10.1186/2008‑2231‑21‑39 23701832
    [Google Scholar]
  46. Soltani S. Amin G. Salehi-Sourmaghi M.H. Iranshahi M. Histone deacetylase inhibitory and cytotoxic activities of the constituents from the roots of three species of Ferula. Iran. J. Basic Med. Sci. 2019 22 1 93 98 30944714
    [Google Scholar]
  47. Zhang H. Xu H. Ashby C.R. Jr Assaraf Y.G. Chen Z.S. Liu H.M. Chemical molecular‐based approach to overcome multidrug resistance in cancer by targeting P‐glycoprotein (P‐gp). Med. Res. Rev. 2021 41 1 525 555 10.1002/med.21739 33047304
    [Google Scholar]
  48. Al Khoury C. Thoumi S. Tokajian S. Sinno A. Nemer G. El Beyrouthy M. Rahy K. ABC transporter inhibition by beauvericin partially overcomes drug resistance in Leishmania tropica. Antimicrob. Agents Chemother. 2024 68 5 e01368-23 10.1128/aac.01368‑23 38572959
    [Google Scholar]
  49. Iranshahi M. Barthomeuf C. Bayet-Robert M. Chollet P. Davoodi D. Piacente S. Rezaee R. Sahebkar A. Drimane-type sesquiterpene coumarins from Ferula gummosa fruits enhance doxorubicin uptake in doxorubicin-resistant human breast cancer cell line. J. Tradit. Complement. Med. 2014 4 2 118 125 10.4103/2225‑4110.126181 24860735
    [Google Scholar]
  50. Khaliq R. Iqbal P. Wani A.Y. Colorectal Cancer: Natural Products as a Treatment. Handbook of Research on Natural Products and Their Bioactive Compounds as Cancer Therapeutics. IGI Global 2022 119 152 10.4018/978‑1‑7998‑9258‑8.ch006
    [Google Scholar]
  51. Cheraghi O. Dehghan G. Mahdavi M. Rahbarghazi R. Rezabakhsh A. Charoudeh H.N. Iranshahi M. Montazersaheb S. Potent anti-angiogenic and cytotoxic effect of conferone on human colorectal adenocarcinoma HT-29 cells. Phytomedicine 2016 23 4 398 405 10.1016/j.phymed.2016.01.015 27002410
    [Google Scholar]
  52. Neshatia V. Matin M.M. Iranshahi M. Bahrami A.R. Behravan J. Mollazadeh S. Rassouli F.B. Cytotoxicity of vincristine on the 5637 cell line is enhanced by combination with conferone. Z. Naturforsch. C J. Biosci. 2009 64 5-6 317 322 10.1515/znc‑2009‑5‑602 19678531
    [Google Scholar]
  53. Maleki E.H. Bahrami A.R. Sadeghian H. Matin M.M. Discovering the structure–activity relationships of different O-prenylated coumarin derivatives as effective anticancer agents in human cervical cancer cells. Toxicol. In Vitro 2020 63 104745 10.1016/j.tiv.2019.104745 31830504
    [Google Scholar]
  54. Kiseleva V.V. Nikonov G.K. Karryev M.O. The structure of diversin and diversinin — Coumarins of Ferula diversivittata. Chem. Nat. Compd. 1975 11 3 358 361 10.1007/BF00571206
    [Google Scholar]
  55. Haghighitalab A. Moghaddam Matin M. Bahrami A.R. Iranshahi M. In vitro investigation of diversin cytotoxicity on 5637 cells. 2010 Available from: https://profdoc.um.ac.ir/articles/a/1019488.pdf(accessed on 8-10-2024)
  56. Haghighitalab A. Matin M.M. Bahrami A.R. Iranshahi M. Saeinasab M. Haghighi F. In vitro investigation of anticancer, cell-cycle-inhibitory, and apoptosis-inducing effects of diversin, a natural prenylated coumarin, on bladder carcinoma cells. Z. Naturforsch. C J. Biosci. 2014 69 3-4 99 109 10.5560/znc.2013‑0006 24873030
    [Google Scholar]
  57. Iranshahi M. Sahebkar A. Hosseini S.T. Takasaki M. Konoshima T. Tokuda H. Cancer chemopreventive activity of diversin from Ferula diversivittata in vitro and in vivo. Phytomedicine 2010 17 3-4 269 273 10.1016/j.phymed.2009.05.020 19577457
    [Google Scholar]
  58. Miski M. Mabry T.J. Daucane esters from Ferula communis subsp. communis. Phytochemistry 1985 24 8 1735 1741 [DOI: https://doi.org/10.1016/S0031-9422(00)82543-1]. 10.1016/S0031‑9422(00)82543‑1
    [Google Scholar]
  59. Iranshahi M. Rezaee R. Najaf Najafi M. Haghbin A. Kasaian J. Cytotoxic activity of the genus Ferula (Apiaceae) and its bioactive constituents. Avicenna J. Phytomed. 2018 8 4 296 312 30377589
    [Google Scholar]
  60. Zanoli P. Zavatti M. Geminiani E. Corsi L. Baraldi M. The phytoestrogen ferutinin affects female sexual behavior modulating ERα expression in the hypothalamus. Behav. Brain Res. 2009 199 2 283 287 10.1016/j.bbr.2008.12.009 19124045
    [Google Scholar]
  61. Abourashed E.A. Galal A.M. Shibl A.M. Antimycobacterial activity of ferutinin alone and in combination with antitubercular drugs against a rapidly growing surrogate of Mycobacterium tuberculosis. Nat. Prod. Res. 2011 25 12 1142 1149 10.1080/14786419.2010.481623 21442547
    [Google Scholar]
  62. Zavatti M. Guida M. Maraldi T. Beretti F. Bertoni L. La Sala G.B. De Pol A. Estrogen receptor signaling in the ferutinin-induced osteoblastic differentiation of human amniotic fluid stem cells. Life Sci. 2016 164 15 22 10.1016/j.lfs.2016.09.005 27629493
    [Google Scholar]
  63. Safi R. Rodriguez F. Hilal G. Diab-Assaf M. Diab Y. El-Sabban M. Najjar F. Delfourne E. Hemisynthesis, antitumoral effect, and molecular docking studies of ferutinin and its analogues. Chem. Biol. Drug Des. 2016 87 3 382 397 10.1111/cbdd.12670 26432755
    [Google Scholar]
  64. Poli F. Appendino G. Sacchetti G. Ballero M. Maggiano N. Ranelletti F.O. Antiproliferative effects of daucane esters from Ferula communis and F. arrigonii on human colon cancer cell lines. Phytother. Res. 2005 19 2 152 157 10.1002/ptr.1443 15852493
    [Google Scholar]
  65. Arghiani N. Matin M.M. Bahrami A.R. Iranshahi M. Sazgarnia A. Rassouli F.B. Investigating anticancer properties of the sesquiterpene ferutinin on colon carcinoma cells, in vitro and in vivo. Life Sci. 2014 109 2 87 94 10.1016/j.lfs.2014.06.006 24953605
    [Google Scholar]
  66. Matin M.M. Nakhaeizadeh H. Bahrami A.R. Iranshahi M. Arghiani N. Rassouli F.B. Ferutinin, an apoptosis inducing terpenoid from Ferula ovina. Asian Pac. J. Cancer Prev. 2014 15 5 2123 2128 10.7314/APJCP.2014.15.5.2123 24716944
    [Google Scholar]
  67. Tang J. Luo Y. Tian Z. Liao X. Cui Q. Yang Q. Wu G. TRIM11 promotes breast cancer cell proliferation by stabilizing estrogen receptor α. Neoplasia 2020 22 9 343 351 10.1016/j.neo.2020.06.003 32599554
    [Google Scholar]
  68. Safi R. Hamade A. Bteich N. El Saghir J. Assaf M.D. El-Sabban M. Najjar F. A ferutinin analogue with enhanced potency and selectivity against ER-positive breast cancer cells in vitro. Biomed. Pharmacother. 2018 105 267 273 10.1016/j.biopha.2018.05.058 29860218
    [Google Scholar]
  69. Severini C. Mascolo M.G. Morandi E. Silingardi P. Horn W. Perdichizzi S. Vaccari M. Colacci A. 509 POSTER Evaluation of in vitro toxicity and efficacy of ferutinin, a natural promising chemoprevantive compound. Eur. J. Cancer, Suppl. 2006 4 12 155 10.1016/S1359‑6349(06)70514‑6
    [Google Scholar]
  70. Macrì R. Bava I. Scarano F. Mollace R. Musolino V. Gliozzi M. Greco M. Foti D. Tucci L. Maiuolo J. Carresi C. Tavernese A. Palma E. Muscoli C. Mollace V. In Vitro Evaluation of Ferutinin Rich-Ferula communis L., ssp. glauca, Root Extract on Doxorubicin-Induced Cardiotoxicity: Antioxidant Properties and Cell Cycle Modulation. Int. J. Mol. Sci. 2023 24 16 12735 10.3390/ijms241612735 37628916
    [Google Scholar]
  71. Alkhatib R. Hennebelle T. Joha S. Idziorek T. Preudhomme C. Quesnel B. Sahpaz S. Bailleul F. Activity of elaeochytrin A from Ferula elaeochytris on leukemia cell lines. Phytochemistry 2008 69 17 2979 2983 10.1016/j.phytochem.2008.09.019 18992904
    [Google Scholar]
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  • Article Type:
    Review Article
Keywords: conferone ; diversin ; Ferula ; cancer ; anticancer mechanisms ; ferutinin
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