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image of Capivasertib: First Approved AKT inhibitor for the Treatment of Patients with Breast Cancer

Abstract

Breast cancer frequently occurs in women. Among the several types of breast cancers almost 50% of breast cancers are caused by one or more gene mutations of the PI3K/mTOR/AKT pathway. Capivasertib the first AKT inhibitor was authorized by the US FDA on November 16 2023.. It is used for the treatment of adult patients with hormone receptor-positive human epidermal growth factor receptor 2 negative metastatic breast cancer with at least one alteration on In this short perspective Capivasertib’s physicochemical properties synthesis mechanism of action binding mode pharmacokinetics drug interaction studies and treatment-emergent adverse events are discussed.

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2024-12-04
2025-01-18
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