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- Volume 21, Issue 27, 2015
Current Pharmaceutical Design - Volume 21, Issue 27, 2015
Volume 21, Issue 27, 2015
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Dry Powder Formulation of Plasmid DNA and siRNA for Inhalation
Authors: Michael Y.T. Chow and Jenny K.W. LamNucleic acid therapeutics has huge potential for the treatment of a wide range of diseases including respiratory diseases. Plasmid DNA (pDNA) and small interfering RNA (siRNA) are the two most widely investigated nucleic acids for therapeutic development. However, efficient and safe delivery of nucleic acids is still a major hurdle in translating nucleic acid therapy into clinical practice. For the treatment of respiratory diseases, a Read More
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Formulation Approaches to Overcome Biopharmaceutical Limitations of Inhaled Peptides/Proteins
Authors: Satomi Onoue, Hiroki Suzuki and Yoshiki SetoThe pulmonary dosing route has been advocated as an attractive alternative to injection and oral administration for the systemic delivery of therapeutic peptides and proteins. The lung possesses many favorable physiological characteristics for systemic absorption of inhaled peptides/proteins, so inhalable formulation systems of these drugs have generated considerable interest as a valid and non-invasive dosi Read More
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Inhaled Formulation Design for the Treatment of Lung Infections
Authors: Lucila Garcia-Contreras and Khushwant S. YadavLung infections may be bacterial, viral or fungal and they are typically treated with oral or parenteral antibiotics. Inhaled dry powder formulations offer unique opportunities for treating lung infections with enhanced effectiveness and stability. Since drug delivery to the lungs requires chronic and repeated administration of larger amounts of therapeutics, dry powder formulations are attractive alternatives to deliver drugs dire Read More
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Powder Production and Particle Engineering for Dry Powder Inhaler Formulations
Authors: Yu-Wei Lin, Jennifer Wong, Li Qu, Hak-Kim Chan and Qi (Tony) ZhouDry powder inhalers have become increasingly attractive for pulmonary delivery of locally and systemically effective medications. In comparison to the liquid counterparts, such as nebulisation and pressurised metered dose inhalers, the powder form generally offers better chemical stability, improved portability and potentially superior patient adherence. Currently, the aerosol performance between dry powder inhalers varies Read More
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Chinese Medicine in Inhalation Therapy: A Review of Clinical Application and Formulation Development
Authors: Xiaoqing Miao, Jing Zhou, Jian Li, Yonghong Liao and Ying ZhengChinese medicine (CM) in inhalation therapy has a long history of applications since ancient China in the forms of smoke, steam vapor, medicated pillows and aromatic sachets. Over the years, thousands of clinical treatments involving the inhalation of CMs have been reported for the treatment of respiratory disease. Shuanghuanglian, Yuxingcao and Qingkailing are primarily applied in pneumonia and bronchitis. At present, mete Read More
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Surface Energy Determined by Inverse Gas Chromatography as a Tool to Investigate Particulate Interactions in Dry Powder Inhalers
Authors: Shyamal C. Das, Ian G. Tucker and Peter J. StewartDry powder inhalers (DPIs) usually contain drug particles <6 μm which agglomerate and/ or adhere on the surfaces of large carriers particles. The detachment of drug particles from carriers and de-agglomeration of drug particles into primary particles is essential for drug deposition in the deep lung. These processes are influenced by the surface energy of particles. Inverse gas chromatography (IGC) has been used to determine Read More
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Electrostatics of Pharmaceutical Aerosols for Pulmonary Delivery
More LessThis paper provides a review on key research findings in the rapidly developing area of pharmaceutical aerosol electrostatics. Solids and liquids can become charged without electric fields, the former by contact or friction and the latter by flowing or spraying. Therefore, charged particles and droplets carrying net charges are produced from pharmaceutical inhalers (e.g. dry powder inhalers, metered dose inhalers, and nebulis Read More
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A Review of Methods for Evaluating Particle Stability in Suspension Based Pressurized Metered Dose Inhalers
Authors: Dexter D128;™Sa and Hak-Kim ChanAdvances in particle engineering techniques, such as spray drying, freeze drying and supercritical fluid precipitation, have greatly enhanced the ability to control the structure, morphology, and solid state phase of inhalable sized particles (1 - 5 μm) for formulation in pressurized metered dose inhalers (pMDI). To optimize the properties of these engineered particles for formulation in hydrofluoroalkane propellants (HFA 134a / 22 Read More
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Discrete Modelling of Powder Dispersion in Dry Powder Inhalers - A Brief Review
Authors: Zhenbo Tong, Aibing Yu, Hak-Kim Chan and Runyu YangThe performance of a dry powder inhaler (DPI) depends on powder properties as well as the air and particle flows in the device. The main principle of powder dispersion is to overcome the inter-particle cohesion using various dispersion/ de-agglomeration forces. While different dispersion mechanisms have been identified, their relative importance under different conditions is less clear. The lack of understanding of these Read More
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The Role of Inspiratory Pressures in Determining the Flow Rates Though Dry Powder Inhalers; A Review
More LessDry powder inhalers are one of the most popular devices for delivering medication directly to the lungs of patients. Both for local action and when using the lungs as a portal of entry into the systemic circulation. Dry powder inhalers rely on the patient’s inspiratory effort to supply the energy for the device to effectively deliver medication. In this respect they are limited by the airway pressures that a patient can generate with thei Read More
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Use of Extrathoracic Deposition Models for Patient-Specific Dose Estimation during Inhaler Design
Authors: Nicholas B. Carrigy, Andrew R. Martin and Warren H. FinlayThe lung dose of inhaled pharmaceutical aerosol that an individual will receive from an inhaler can now be more accurately estimated in light of recent extrathoracic deposition modeling that has correlated characteristic airway dimensions with deposition. This paper first summarizes the current state of extrathoracic deposition models, including recent developments that have quantified the effects of aerosol electrostatic Read More
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Volumes & issues
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Volume 31 (2025)
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Volume 30 (2024)
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Volume 29 (2023)
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Volume 28 (2022)
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Volume 27 (2021)
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Volume 26 (2020)
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Volume 25 (2019)
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Volume 24 (2018)
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Volume 23 (2017)
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Volume 22 (2016)
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Volume 21 (2015)
- Issue 42
- Issue 41
- Issue 40
- Issue 39
- Issue 38
- Issue 37
- Issue 36
- Issue 35
- Issue 34
- Issue 33
- Issue 32
- Issue 31
- Issue 30
- Issue 29
- Issue 28
- Issue 27
- Issue 26
- Issue 25
- Issue 24
- Issue 23
- Issue 22
- Issue 21
- Issue 20
- Issue 19
- Issue 18
- Issue 17
- Issue 16
- Issue 15
- Issue 14
- Issue 13
- Issue 12
- Issue 11
- Issue 10
- Issue 9
- Issue 8
- Issue 7
- Issue 6
- Issue 5
- Issue 4
- Issue 3
- Issue 2
- Issue 1
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Volume 20 (2014)
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Volume 19 (2013)
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Volume 18 (2012)
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Volume 17 (2011)
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Volume 16 (2010)
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Volume 15 (2009)
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Volume 14 (2008)
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Volume 13 (2007)
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Volume 12 (2006)
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Volume 11 (2005)
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Volume 10 (2004)
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Volume 9 (2003)
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Volume 8 (2002)
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Volume 7 (2001)
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Volume 6 (2000)
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