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- Volume 21, Issue 22, 2015
Current Pharmaceutical Design - Volume 21, Issue 22, 2015
Volume 21, Issue 22, 2015
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Recent Advances and Strategies in Tumor Vasculature Targeted Nano-Drug Delivery Systems
Authors: Man Ying, Guanyu Chen and Weiyue LuIn recent decades, targeted nano-drug delivery systems have attracted extensive attention in cancer therapy for their efficient drug delivery and tumor site specificity. Tumor vasculature, including angiogenesis and vasculogenic mimicry is associated tightly with tumor growth, progression and metastasis. Therefore, nano-drug delivery systems targeting tumor vasculature are becoming a promising approach for tumor treatme Read More
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Current Nanotechnological Approaches for an Effective Delivery of Bioactive Drug Molecules to Overcome Drug Resistance Tuberculosis
Authors: Tarun Garg, Goutam Rath, Rayasa R. Murthy, Umesh D. Gupta, Palakkod G. Vatsala and Amit K. GoyalTuberculosis (TB) is an airborne communicable disease, mainly caused by aerobic, non-motile, rodshaped, weakly gram-positive, acid-fast tubercular bacillus Mycobacterium tuberculosis (MTb). Mycobacterium has worsened the problem in humans by acquiring various types of resistances like Multi-drug resistance (MDR), Single-drug resistance (SDR), and Extensive drug resistance (XDR). Some clinical problems Read More
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Hydrophilic Polymers for Modified-Release Nanoparticles: A Review of Mathematical Modelling for Pharmacokinetic Analysis
Hydrophilic polymers are the most common group of polymers used in the preparation of modifiedrelease drug delivery systems. This is due to their versatility, low cost, high production yield, as well as easy manufacturing and adequate in vitro/in vivo correlation. In normal physiological conditions, the matrix controls the release of the loaded drug over time through a process of diffusion and/or erosion of the matrix, dep Read More
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Multifunctional Delivery Systems for Advanced oral Uptake of Peptide/Protein Drugs
Authors: Jin Woo Park, Sun Jin Kim, Dong Sup Kwag, Sol Kim, Jeyoung Park, Yu Seok Youn, You Han Bae and Eun Seong LeeIn recent years, advances in biotechnology and protein engineering have enabled the production of large quantities of proteins and peptides as important therapeutic agents. Various researchers have used biocompatible functional polymers to prepare oral dosage forms of proteins and peptides for chronic use and for easier administration to enhance patient compliance. However, there is a need to enhance their safety Read More
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Emerging Use of Nanotechnology in the Treatment of Neurological Disorders
Authors: Resham Chhabra, Giovanni Tosi and Andreas M. GrabruckerNeurological disorders represent one of the major health concerns worldwide. Yet currently employed treatment strategies have not been very successful in the treatment of many of these disorders. One of the root causes of this lack of success is that many pharmaceutically active compounds are unable to reach their target sites of action inside the body. The delivery of substances from systemic circulation to the d Read More
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Crystallization Methods for Preparation of Nanocrystals for Drug Delivery System
Authors: Yuan Gao, Jingkang Wang, Yongli Wang, Qiuxiang Yin, Brian Glennon, Jian Zhong, Jinbo Ouyang, Xin Huang and Hongxun HaoLow water solubility of drug products causes delivery problems such as low bioavailability. The reduced particle size and increased surface area of nanocrystals lead to the increasing of the dissolution rate. The formulation of drug nanocrystals is a robust approach and has been widely applied to drug delivery system (DDS) due to the significant development of nanoscience and nanotechnology. It can be used to improve drug ef Read More
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Lipid-Based Nanocarriers for RNA Delivery
Authors: Hui Yi Xue, Pengbo Guo, Wu-Cheng Wen and Ho Lun WongRNA-interference (RNAi) agents such as small-interfering RNA (siRNA) and micro-RNA (miRNA) have strong potential as therapeutic agents for the treatment of a broad range of diseases such as malignancies, infections, autoimmune diseases and neurological diseases that are associated with undesirable gene expression. In recent years, several clinical trials of RNAi therapeutics especially siRNAs have been conducted with limi Read More
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Formulation and Stability Aspects of Nanosized Solid Drug Delivery Systems
Authors: Peter Szabo and Romana ZelkoNano drug delivery systems are considered as useful means to remedy the problems of drugs of poor solubility, permeability and bioavailability, which became one of the most troublesome questions of the pharmaceutical industry. Different types of nanosized drug delivery systems have been developed and investigated for oral administration, providing auspicious solutions for drug development. In this paper nanosized dr Read More
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Nanoparticle-Based Combination Therapy for Cancer Treatment
Authors: Ji Young Yhee, Sejin Son, Hyukjin Lee and Kwangmeyung KimIn recent years, combination of different types of therapies using nanoparticles has emerged as an advanced strategy for cancer treatment. Most of all, combination of chemotherapeutic drug and siRNA in nanoformulation has shown a great potential, because siRNA-mediated specific gene silencing can compensate for the incomplete anti-cancer actions of chemotherapy. In this article, nanoparticle-based combination thera Read More
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Functionalized Nanocarriers for Enhanced Bioactive Delivery to Squamous Cell Carcinomas: Targeting Approaches and Related Biopharmaceutical Aspects
Authors: Adeyemi S. Adebowale, Yahya E. Choonara, Pradeep Kumar, Lisa C. du Toit and Viness PillayCancer has been described as one of the major and leading causes of death worldwide. By the year 2030, it has been postulated that over 21.4 million new cases of cancer could be expected, 17 million cancer deaths yearly and a total of 75 million people will be living with cancer within five years of diagnosis. Chemotherapy is the main therapeutic intervention for treating people living with SCC. However, drug resistance has Read More
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Recent Developments of New DNA Origami Nanostructures for Drug Delivery
Authors: Juan Yan, Chongya Hu, Xunwei Liu, Jian Zhong, Gang Sun and Dannong HeDNA origami technique was first introduced in 2006 by Rothemund, it has gained widespread research interest and led to explosive achievements, in which long single-stranded DNA (ssDNA) is folded into a designed nanostructure, in either two dimensions (2D) or three dimensions (3D), with the aid of many shorter staple strands. A series of methods for new design principles for DNA origami nanostructures have already been pr Read More
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Application of Carbon Nanomaterials in Gene Delivery for Endogenous RNA Interference In Vitro and In Vivo
Authors: Lanying Li, Yanli Wen, Qin Xu, Li Xu, Dong Liu, Gang Liu and Qing HuangKnocking down expression by small interfering RNA (siRNA) has shown high affinity, specificity and potency in silencing target gene sites. For effective endogenous RNA interference (RNAi), proper siRNA delivery vehicles are essential, to take the siRNA inside cells and protect them during the circulation. Carbon nanomaterials (CNMs) have been successfully applied in biomedicine and biosensor based on their ultra-high surf Read More
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Zein-Based Nanofibres for Drug Delivery: Classes and Current Applications
Authors: Yong Zhang, Lili Cui, Yan Chen, Heng Zhang, Jian Zhong, Yanan Sun, Nianqiu Shi, Chunlei Li and Wei KongPlant proteins have been drawing increasing attention owing to their safety, abundance and relatively low cost in comparison with animal proteins. The development of plant protein-based delivery vehicles may lead to the provision of novel pharmaceutical products to patients. Zein is a class of alcohol-soluble prolamine proteins present in maize endosperm that was approved as a generally recognised as safe excipient in 1985 b Read More
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Intratumoral Pharmacokinetics: Challenges to Nanobiomaterials
Authors: Ahmed M. Al-Abd, Fahad A. Al-Abbasi and Vladimir P. TorchilinResistance of solid tumors to treatment is significantly attributed to pharmacokinetic reasons at both cellular and multi-cellular levels. Anticancer agent must be bio-available at the site of action in a cytotoxic concentration to exert its proposed activity. Solid tumor tissue is characterized by high density of vascular bed however; the vast majority of these blood vessels are not functioning. The vast majority of solid tumors can Read More
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Graphene Oxide-Based Nanocarriers for Cancer Imaging and Drug Delivery
Authors: Peihong You, Yang Yang, Mingwei Wang, Xiaoyu Huang and Xiao HuangNano graphene oxide (nGO) is a member of graphene family, which is a novel, one-atom-thickness, two-dimensional carbon nanomaterial. In comparison with graphene, nGO contains much higher extent of reactive chemical functionalities such as hydroxyl, carbonyl, carboxyl, and epoxy group, so as to enable its easier biochemo-functionalization, higher biocompatibility, and greater potentials of applications in biomedicin Read More
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Multidimensional Ophthalmic Nanosystems for Molecular Detection and Therapy of Eye Disorders
Authors: Swati Vyas, Pratik Kakade, Manasi Chogale, John Disouza and Vandana PatravaleSymptomatic distresses associated with common ophthalmic infections and their persistence, have remained a tribulation with repeated occurrences. Although being a directly accessible organ, traditional therapeutic strategies exhibiting seemingly fruitful outcome in treatment and prognosis of eye disorders call for improvement in disease intervention. This is due to frequent challenges presented by the ophthalmic Read More
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EHDA Spraying: A Multi-Material Nano-Engineering Route
Electrohydrodynamic atomization (EHDA) enabling platform technologies have gathered significant momentum over the last two decades. Utilisation of the underpinning jetting process in tandem with desired materials (including polymers, ceramics, metals and even naturally occurring compounds such as peptides, DNA and cells) provides the basis for novel engineered therapies. Through EHDA processes, the generatio Read More
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Generation of Targeted Adeno-Associated Virus (AAV) Vectors for Human Gene Therapy
Authors: Yarong Liu, Natnaree Siriwon, Jennifer A. Rohrs and Pin WangAdeno-associated virus (AAV) vectors are promising human gene delivery vehicles due to their ability to establish long-term gene expression in a wide variety of target tissues; however, the broad native viral tropism raises concerns over the feasibility and safety of their systemic administration. To overcome this issue, much effort has been made to redirect AAVs toward specific tissues. This review presents severa Read More
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Volumes & issues
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Volume 31 (2025)
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Volume 30 (2024)
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Volume 29 (2023)
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Volume 28 (2022)
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Volume 27 (2021)
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Volume 26 (2020)
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Volume 25 (2019)
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Volume 24 (2018)
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Volume 23 (2017)
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Volume 22 (2016)
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Volume 21 (2015)
- Issue 42
- Issue 41
- Issue 40
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- Issue 14
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- Issue 12
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- Issue 4
- Issue 3
- Issue 2
- Issue 1
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Volume 20 (2014)
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Volume 19 (2013)
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Volume 18 (2012)
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Volume 17 (2011)
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Volume 16 (2010)
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Volume 15 (2009)
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Volume 14 (2008)
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Volume 13 (2007)
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Volume 12 (2006)
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Volume 11 (2005)
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Volume 10 (2004)
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Volume 9 (2003)
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Volume 8 (2002)
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Volume 7 (2001)
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Volume 6 (2000)
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