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- Volume 21, Issue 28, 2015
Current Pharmaceutical Design - Volume 21, Issue 28, 2015
Volume 21, Issue 28, 2015
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Hallmarks in the Therapeutic Approach of Aortic Aneurysms: The Main Contributors
Deriving from the Greek word for “widening”, aneurysms have been a well known entity since antiquity. In the 2nd century AD, Antyllos, the Greek born surgeon who practiced in Rome, described a method for aneurysms’ surgical removal that remained a standard procedure till the 19th century. In 18th century John Hunter proposed a limb saving operation method for treating peripheral aneurysms paving thus the way fo Read More
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Emerging Pharmacological Treatments to Prevent Abdominal Aortic Aneurysm Growth and Rupture
Authors: Rodrigo A. Fraga-Silva, Bram Trachet and Nikolaos StergiopulosAbdominal aortic aneurysm (AAA) is a local expansion of the abdominal aorta wall caused by a complex multifactorial maladaptive vascular remodeling. Despite recent advances in the management of cardiovascular diseases, there currently is no established drug therapy for AAA. Since the probability of death from a ruptured AAA still remains high, preventive elective repair of AAAs larger than 5.5 cm in luminal diamete Read More
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Monocytes, Macrophages and Other Inflammatory Mediators of Abdominal Aortic Aneurysm
Authors: Stephane Potteaux and Alain TedguiMacrophages early invade the forming abdominal aortic aneurysm (AAA) and greatly contribute to its pathogenesis. Recent findings have shown that Ly-6Chigh and Ly-6Clow monocytes are rapidly mobilized from the splenic reservoir in response to angiotensin II infusion and sequentially infiltrate the abdominal aorta. The first wave of Ly-6Chigh monocytes prevails in the aorta and promotes the accumulation of inflammat Read More
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The Role of Endothelial Dysfunction in Aortic Aneurysms
Authors: Gerasimos Siasos, Konstantinos Mourouzis, Evangelos Oikonomou, Sotirios Tsalamandris, Vasiliki Tsigkou, Konstantinos Vlasis, Manolis Vavuranakis, Thodoris Zografos, Stathis Dimitropoulos, Theodore G. Papaioannou, Aimilios Kalampogias, Christodoulos Stefanadis, Athanasios G. Papavassiliou and Dimitris TousoulisAbdominal aortic aneurysm is a vascular disease which, despite the fact that it shares common risk factors with atherosclerosis, develops in parallel but as a partly independent process, through different pathogenic mechanisms. The pathogenic mechanisms involve metalloproteinase and collagenase activation, median and adventitial degradation, elastin lysis, vascular smooth cells transformation and apoptosis, collagen p Read More
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Angiotensin II and Abdominal Aortic Aneurysms: An update
Authors: Jing Liu, Alan Daugherty and Hong LuAbdominal aortic aneurysm (AAA) is a devastating disease associated with high prevalence of death due to aortic rupture. Currently the therapy is restricted to surgical procedures to prevent aortic rupture, which in turn has a risk for postoperative mortality. There are no proven pharmacological therapies available to prevent expansion or rupture of AAA due to the paucity of knowledge on the mechanisms underl Read More
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Dissecting abdominal aortic aneurysm in Angiotensin II-infused mice: the importance of imaging
Introduction. Since the initial publication in 2000, Angiotensin II-infused mice have become one of the most popular models to study abdominal aortic aneurysm in a pre-clinical setting. We recently used phase contrast X-ray based computed tomography to demonstrate that these animals develop an apparent luminal dilatation and an intramural hematoma, both related to mural ruptures in the tunica media in the vicinity o Read More
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Marfan Syndrome and Related Heritable Thoracic Aortic Aneurysms and Dissections
In this overview we aim to address a number of recent insights and developments regarding clinical aspects, etiology, and treatment of Heritable Thoracic Aortic Disease (H-TAD). We will focus on monogenetic disorders related to aortic aneurysms. H-TADs are rare but they provide a unique basis for the study of underlying pathogenetic pathways in the complex disease process of aneurysm formation. The understanding of p Read More
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Endovascular Versus Open Abdominal Aortic Aneurysm: Best Decision
Since the first implantation of an endograft in 1991, endovascular aneurysm repair (EVAR) rapidly gained recognition. Historical trials showed lower early mortality rates but these results were not maintained beyond 4 years. Despite newer-generation devices, higher rates of reintervention are associated with EVAR during follow-up. Therefore, the best therapeutic decision relies on many parameters that the physician has to tak Read More
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Abdominal Aortic Aneurysm: What About Screening?
The prevalence of abdominal aortic aneurysm (AAA) in general population is 4-9% with a high mortality rate when ruptured. Therefore, screening programs were developed in many countries to detect small and large AAA in selected patients. Indeed, prevalence of AAA increases in patients over 65 years old with cigarette smoking history. This paper reviews recent literature related to AAA screening focusing on epidemiology Read More
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Acridine Orange is an Effective Anti-Cancer Drug that Affects Mitochondrial Function in Osteosarcoma Cells
Authors: Caterina Fotia, Sofia Avnet, Katsuyuki Kusuzaki, Laura Roncuzzi and Nicola BaldiniAcridine orange (AO) is an antimalarial drug that accumulates into acidic cellular compartments. Lysosomes are quite acidic in cancer cells, and on this basis we have demonstrated that photoactivated AO is selectively toxic in sarcomas. However, photodynamic therapy is only locally effective, and cannot be used to eradicate systemic residual disease. In this study, we have evaluated the activity of non-photoactivated AO on se Read More
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Insights in Nanoparticle-Bacterium Interactions: New Frontiers to Bypass Bacterial Resistance to Antibiotics
Authors: Roudayna Diab, Bahman Khameneh, Olivier Joubert and Raphael DuvalNanotechnology has been revealed as a fundamental approach for antibiotics delivery. In this paper, recent findings demonstrating the superiority of nanocarried-antibiotics over “naked” ones and the ways by which nanoparticles can help to overwhelm bacterial drug resistance are reviewed. The second part of this paper sheds light on nanoparticle-bacterium interaction patterns. Finally, key factors affecting the effectiveness Read More
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Repurposing Non-Antimicrobial Drugs and Clinical Molecules to Treat Bacterial Infections
Authors: Waleed Younis, Shankar Thangamani and Mohamed N. SeleemThere is a pressing need to develop novel antimicrobials to circumvent the scourge of antimicrobial resistance. The objective of this study is to identify non-antibiotic drugs with potent antimicrobial activity, within an applicable clinical range. A library, containing 727 FDA approved drugs and small molecules, was screened against ESKAPE pathogens (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acin Read More
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Rational Design of Antimalarial Drugs Using Molecular Modeling and Statistical Analysis
Authors: Cleydson Breno Rodrigues dos Santos, Cleison Carvalho Lobato, Francinaldo Sarges Braga, Josivan da Silva Costa, Hugo Alexandre Silva Favacho, Jose Carlos Tavares Carvalho, Williams Jorge da Cruz Macedo, Davi Do Socorro Barros Brasil, Carlos Henrique Tomich de Paula da Silva and Lorane Izabel da Silva Hage-MelimArtemisinin is an antimalarial compound isolated from Artemisia annua L. that is effective against Plasmodium falciparum. This paper proposes the development of new antimalarial derivatives of artemisinin from a SAR study and statistical analysis by multiple linear regression (MLR). The HF/6-31G** method was used to determine the molecular properties of artemisinin and 10 derivatives with antimalarial action. MEP maps and Read More
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Volumes & issues
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Volume 31 (2025)
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Volume 30 (2024)
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Volume 29 (2023)
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Volume 28 (2022)
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Volume 27 (2021)
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Volume 26 (2020)
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Volume 25 (2019)
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Volume 24 (2018)
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Volume 23 (2017)
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Volume 22 (2016)
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Volume 21 (2015)
- Issue 42
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- Issue 1
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Volume 20 (2014)
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Volume 19 (2013)
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Volume 18 (2012)
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Volume 17 (2011)
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Volume 16 (2010)
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Volume 15 (2009)
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Volume 14 (2008)
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Volume 13 (2007)
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Volume 12 (2006)
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Volume 11 (2005)
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Volume 10 (2004)
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Volume 9 (2003)
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Volume 8 (2002)
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Volume 7 (2001)
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Volume 6 (2000)
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