- Home
- A-Z Publications
- Current Pharmaceutical Design
- Previous Issues
- Volume 21, Issue 1, 2015
Current Pharmaceutical Design - Volume 21, Issue 1, 2015
Volume 21, Issue 1, 2015
-
-
Quorum Sensing Inhibitors as Anti-Biofilm Agents
Authors: Gilles Brackman and Tom CoenyeBiofilms are microbial sessile communities characterized by cells that are attached to a substratum or interface or to each other, are embedded in a self-produced matrix of extracellular polymeric substances and exhibit an altered phenotype compared to planktonic cells. Biofilms are estimated to be associated with 80% of microbial infections and it is currently common knowledge that growth of micro-organisms in biofilms can Read More
-
-
-
Targeting Cyclic di-GMP Signalling: A Strategy to Control Biofilm Formation?
Authors: Delphine L. Caly, Domenico Bellini, Martin A. Walsh, J. Maxwell Dow and Robert P. RyanCyclic di-GMP is a second messenger found in almost all eubacteria that acts to regulate a wide range of functions including developmental transitions, adhesion and biofilm formation. Cyclic di-GMP is synthesised from two GTP molecules by diguanylate cyclases that have a GGDEF domain and is degraded by phosphodiesterases with either an EAL or an HD-GYP domain. Proteins with these domains often contain add Read More
-
-
-
Quorum Sensing and Biofilms in the Pathogen, Streptococcus pneumoniae
Authors: Joana Galante, Alfred C-Y Ho, Sarah Tingey and Bambos M. CharalambousBacteria are able to colonize and thrive in a variety of different environments as a biofilm, but only within the last half century new insights have been gained in this complex biosystem. Bacterial biofilms play a major role in human health by forming a defensive barrier against antibacterial chemical therapeutics and other potential pathogens, and in infectious disease when the bacteria invade normally sterile compartments Read More
-
-
-
Nitric Oxide: A Key Mediator of Biofilm Dispersal with Applications in Infectious Diseases
Authors: Nicolas Barraud, Michael J. Kelso, Scott A. Rice and Staffan KjellebergStudies of the biofilm life cycle can identify novel targets and strategies for improving biofilm control measures. Of particular interest are dispersal events, where a subpopulation of cells is released from the biofilm community to search out and colonize new surfaces. Recently, the simple gas and ubiquitous biological signaling molecule nitric oxide (NO) was identified as a key mediator of biofilm dispersal conserved across micr Read More
-
-
-
Strategies for Antimicrobial Drug Delivery to Biofilm
Biofilms are formed by the attachment of single or mixed microbial communities to a variety of biological and/or synthetic surfaces. Biofilm micro-organisms benefit from many advantages of the polymicrobial environment including increased resistance against antimicrobials and protection against the host organism’s defence mechanisms. These benefits stem from a number of structural and physiological differences betwe Read More
-
-
-
Potential Application of Antimicrobial Peptides in the Treatment of Bacterial Biofilm Infections
Authors: Nikola Strempel, Janine Strehmel and Joerg OverhageThe increasing prevalence of persistent biofilm infections, such as wound infections, chronic lung infections or medical device- related infections, which usually tolerate conventional antibiotic treatment, calls for the development of new therapeutic strategies. To date, antimicrobial peptides (AMPs) are considered as promising agents in the fight against multidrug-resistant bacterial biofilm infections, since many of them have Read More
-
-
-
Bacteriophages and their Enzymes in Biofilm Control
Authors: Benjamin K. Chan and Stephen T. AbedonAlthough free-swimming planktonic bacteria historically have been the typical focus of microbiological studies, the natural state of many or most bacteria is one where they instead are associated with surfaces and/or each other. For many pathogenic as well as nuisance bacteria, including biofouling bacteria, it consequently is within the context of this biofilm state that antibacterial strategies must be implemented. For reas Read More
-
-
-
Current and Future Approaches to the Prevention and Treatment of Staphylococcal Medical Device-Related Infections
Authors: S. Hogan, N.T. Stevens, H. Humphreys, J.P. O'Gara and E. O'NeillStaphylococci, in particular Staphylococcus aureus and Staphylococcus epidermidis, are a leading cause of healthcareassociated infections. Patients who have a medical device inserted are at particular risk of an infection with these organisms as staphylococci possess a wide range of immune evasion mechanisms, one of which being their ability to form biofilm. Once embedded in a biofilm, bacteria are inherently mor Read More
-
-
-
The APOE Genotype: Modification of Therapeutic Responses in Alzheimer's Disease
Authors: Angela J. Hanson, Suzanne Craft and William A. BanksThe translation of promising preclinical treatments into effective drugs for Alzheimer's disease (AD) has been challenging. One of the most potent risk factors for sporadic AD is carrier status of the epsilon 4 allele of the apolipoprotein E gene (E4). E4 carriers show a differential response to several therapies which are being investigated as AD treatments, including acetylcholinesterase inhibitors and therapeutics with vascula Read More
-
-
-
Clinical Applications of Choline PET/CT in Brain Tumors
Malignant gliomas and metastatic tumors are the most common forms of brain tumors. From a clinical perspective, neuroimaging plays a significant role, in diagnosis, treatment planning, and follow-up. To date MRI is considered the current clinical gold standard for imaging, however, despite providing superior structural detail it features poor specificity in identifying viable tumors in brain treated with surgery, radiation, Read More
-
Volumes & issues
-
Volume 31 (2025)
-
Volume 30 (2024)
-
Volume 29 (2023)
-
Volume 28 (2022)
-
Volume 27 (2021)
-
Volume 26 (2020)
-
Volume 25 (2019)
-
Volume 24 (2018)
-
Volume 23 (2017)
-
Volume 22 (2016)
-
Volume 21 (2015)
- Issue 42
- Issue 41
- Issue 40
- Issue 39
- Issue 38
- Issue 37
- Issue 36
- Issue 35
- Issue 34
- Issue 33
- Issue 32
- Issue 31
- Issue 30
- Issue 29
- Issue 28
- Issue 27
- Issue 26
- Issue 25
- Issue 24
- Issue 23
- Issue 22
- Issue 21
- Issue 20
- Issue 19
- Issue 18
- Issue 17
- Issue 16
- Issue 15
- Issue 14
- Issue 13
- Issue 12
- Issue 11
- Issue 10
- Issue 9
- Issue 8
- Issue 7
- Issue 6
- Issue 5
- Issue 4
- Issue 3
- Issue 2
- Issue 1
-
Volume 20 (2014)
-
Volume 19 (2013)
-
Volume 18 (2012)
-
Volume 17 (2011)
-
Volume 16 (2010)
-
Volume 15 (2009)
-
Volume 14 (2008)
-
Volume 13 (2007)
-
Volume 12 (2006)
-
Volume 11 (2005)
-
Volume 10 (2004)
-
Volume 9 (2003)
-
Volume 8 (2002)
-
Volume 7 (2001)
-
Volume 6 (2000)
Most Read This Month
Article
content/journals/cpd
Journal
10
5
false
en
