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- Volume 21, Issue 40, 2015
Current Pharmaceutical Design - Volume 21, Issue 40, 2015
Volume 21, Issue 40, 2015
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On the Methods to Measure Powder Flow
Authors: Geoffrey Tan, David A.V. Morton and Ian LarsonThe flow of powders can often play a critical role in the manufacturing of pharmaceutical products. Many of these processes require good, consistent and predictable flow of powders to ensure continuous production of pharmaceutical dosages and to ensure their quality. Therefore, the flow of powders is of paramount importance to the pharmaceutical industry and thus the measuring and evaluating of powder flow is of Read More
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The Application of Modern Powder Characterisation Methods in Product and Process Development of Solid Dosage Forms
Authors: Tim Freeman, Katrina Brockbank and Brian ArmstrongThe pharmaceutical industry still produces the vast majority of their products, from powdered ingredients, in the form of solid doses. Despite their ubiquity, powders are difficult materials to characterise and understand, as evidenced by the frequent problems encountered during manufacture. The reason for this is their complex rheological behaviour coupled with numerous environmental variations, such as humidity. Equally, th Read More
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Amorphous or Crystalline? A Comparison of Particle Engineering Methods and Selection
Authors: Sachin G. Thakkar, Kristin Fathe and Hugh D.C. SmythThis review is intended to provide a critical account of the current goals and technologies of particle engineering regarding the production of crystalline and amorphous particles. The technologies discussed here cover traditional crystallization technologies, supercritical fluid technologies, spray drying, controlled solvent crystallization, and sonocrystallization. Also recent advancements in particle engineering including spray Read More
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Particle Engineering Via Mechanical Dry Coating in the Design of Pharmaceutical Solid Dosage Forms
Authors: Li Qu, David A.V. Morton and Qi (Tony) ZhouCohesive powders are problematic in the manufacturing of pharmaceutical solid dosage forms because they exhibit poor flowability, fluidization and aerosolization. These undesirable bulk properties of cohesive powders represent a fundamental challenge in the design of efficient pharmaceutical manufacturing processes. Recently, mechanical dry coating has attracted increasing attention as it can improve the bul Read More
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Encapsulation of Liquids Via Extrusion - A Review
Authors: Markus W. Tackenberg and Peter KleinebuddeVarious encapsulation techniques are known for pharmaceutical applications. Extrusion is of minor importance. However, extrusion is used to obtain granules with encapsulate liquid active ingredients (AI) like essential oils and flavours for food applications since decades. Many of these AIs can be used for agrochemical, home care, and pharmaceutical products, too. Thus, the focus of this review is on the interdisciplinary pr Read More
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Nanoembedded Microparticles for Stabilization and Delivery of Drug-Loaded Nanoparticles
Authors: Adam Bohr, Jorrit Water, Moritz Beck-Broichsitter and Mingshi YangNanoparticle-based pharmaceutical products are currently finding their way onto the market as a popular strategy to improve the therapeutic efficacy of numerous drugs, hereunder medications for a targeted treatment of severe diseases (e.g., cancer). Drug-loaded polymer and lipid nanoparticles are typically produced via solventbased methods and result in colloidal suspensions, which often suffer from physical and Read More
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Characterizing Protein Structure, Dynamics and Conformation in Lyophilized Solids
Authors: Balakrishnan S. Moorthy, Lavanya K. Iyer and Elizabeth M. ToppThe long-term stability of protein therapeutics in the solid-state depends on the preservation of native structure during lyophilization and in the lyophilized powder. Proteins can reversibly or irreversibly unfold upon lyophilization, acquiring conformations susceptible to degradation during storage. Therefore, characterizing proteins in the dried state is crucial for the design of safe and efficacious formulations. This review su Read More
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Applications of Natural Polymeric Materials in Solid Oral Modified-Release Dosage Forms
Authors: Liang Li, Xin Zhang, Xiangqin Gu and Shirui MaoSolid oral modified-release dosage forms provide numerous advantages for drug delivery compared to dosage forms where the drugs are released and absorbed rapidly following ingestion. Natural polymers are of particular interest as drug carriers due to their good safety profile, biocompatibility, biodegradability, and rich sources. This review described the current applications of important natural polymers, such a Read More
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Controlled Release Inhalable Polymeric Microspheres for Treatment of Pulmonary Arterial Hypertension
Authors: Aparna Saigal, Wai Kiong Ng, Reginald B.H. Tan and Sui Yung ChanPulmonary arterial hypertension (PAH) is a chronic ailment of the lungs, exhibiting elevated arterial pressure and vascular resistance; with a mean arterial pressure above 25 mmHg at rest and above 30 mmHg during exercise. It is associated with poor prognosis, and its prevalence is estimated to be 15 cases per one million. The current treatment options for PAH are discussed with the prostanoid class of drugs being the most ef Read More
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Particle Engineering of Excipients for Direct Compression: Understanding the Role of Material Properties
Authors: Sharad Mangal, Felix Meiser, David Morton and Ian LarsonTablets represent the preferred and most commonly dispensed pharmaceutical dosage form for administering active pharmaceutical ingredients (APIs). Minimizing the cost of goods and improving manufacturing output efficiency has motivated companies to use direct compression as a preferred method of tablet manufacturing. Excipients dictate the success of direct compression, notably by optimizing powder formulati Read More
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IMPACT OF EXCIPIENT VARIABILITY ON DRUG PRODUCT PROCESSING AND PERFORMANCE
Authors: Josephine Lay Peng Soh, Celine Valeria Liew and Paul Wan Sia HengIt is rare to have a pharmaceutical dosage form presented with just the pure active pharmaceutical ingredient because the drug substance does not possess adequately desirable physical attributes to be processed into the final dosage form. Consequently, additives or excipients which are inert ingredients serving a functional purpose are added to enhance the overall properties of the final formulation for ease of processab Read More
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Recent advances in the fundamental understanding of adhesive mixtures for inhalation
Adhesive mixtures for inhalation are the most widely used type of formulation in dry powder inhalation products. Although they have been the subject of active research, the relationships between properties of the starting materials, the mixing and dispersion processes, and the dispersion performance of this type of formulation are generally poorly understood. Interactions between relevant variables have been mentioned Read More
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Numerical Modelling of Agglomeration and Deagglomeration in Dry Powder Inhalers: A Review
Authors: Jiecheng Yang, Chuan-Yu Wu and Michael AdamsNumerical modelling using computational fluid mechanics (CFD) and discrete element method (DEM) becomes increasingly prevalent for the exploration of agglomeration and deagglomeration in dry powder inhalers (DPIs). These techniques provide detailed information on air flow and particle-particle/wall interaction, respectively. Coupling of CFD and DEM enables an in-depth investigation of the mechanisms at the micr Read More
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Impact of Electrostatics on Processing and Product Performance of Pharmaceutical Solids
Manufacturing of pharmaceutical solids involves different unit operations and processing steps such as powder blending, fluidization, sieving, powder coating, pneumatic conveying and spray drying. During these operations, particles come in contact with other particles, different metallic, glass or polymer surfaces and can become electrically charged. Electrostatic charging often gives a negative connotation as it creates s Read More
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Volumes & issues
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Volume 31 (2025)
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Volume 30 (2024)
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Volume 29 (2023)
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Volume 28 (2022)
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Volume 27 (2021)
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Volume 26 (2020)
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Volume 25 (2019)
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Volume 24 (2018)
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Volume 23 (2017)
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Volume 22 (2016)
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Volume 21 (2015)
- Issue 42
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- Issue 12
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- Issue 2
- Issue 1
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Volume 20 (2014)
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Volume 19 (2013)
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Volume 18 (2012)
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Volume 17 (2011)
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Volume 16 (2010)
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Volume 15 (2009)
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Volume 14 (2008)
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Volume 13 (2007)
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Volume 12 (2006)
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Volume 11 (2005)
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Volume 10 (2004)
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Volume 9 (2003)
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Volume 8 (2002)
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Volume 7 (2001)
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Volume 6 (2000)
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