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- Volume 21, Issue 14, 2015
Current Pharmaceutical Design - Volume 21, Issue 14, 2015
Volume 21, Issue 14, 2015
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Understanding the Interaction Between Human Serum Albumin and Anti-Bacterial/ Anti-Cancer Compounds
Authors: Md Tabish Rehman and Asad U. KhanHuman serum albumin (HSA) is the most important carrier of exogenous and endogenous molecules in human plasma. Understanding and characterizing the interaction of drugs with HSA has attracted enormous research interests from decades. The nature and magnitude of these bindings have direct consequence on drug delivery, pharmacokinetics, pharmacodynamics, therapeutic efficacy and drug designing. An Read More
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Understanding the Physical and Chemical Nature of the Warfarin Drug Binding Site in Human Serum Albumin: Experimental and Theoretical Studies
More LessHuman serum albumin (HSA) is one of the major carrier proteins in the body and constitutes approximately half of the protein found in blood plasma. It plays an important role in lipid metabolism, and its ability to reversibly bind a large variety of pharmaceutical compounds makes it a crucial determinant of drug pharmacokinetics and pharmacodynamics. This review deals with one of the protein’s major binding sites “S Read More
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Studies on Drug – Human Serum Albumin Binding: The Current State of the Matter
More LessHuman serum albumin (HSA) is the major plasma protein with vital functions acting as depot and career for many endogenous (fatty acids, bilirubin, etc.) and exogenous substances (drugs, nutrients, etc.) in the blood. Binding to HSA controls the free, active concentration of the drug and may affect considerably the overall pharmacodynamic and pharmacokinetic profile. Studies on drug – protein binding are important fro Read More
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Structure and Enzymatic Activities of Human Serum Albumin
Authors: Yu Wang, Shihua Wang and Mingdong HuangHuman serum albumin (HSA) is the most abundant protein in plasma, and plays multiple roles in physiology, including as a carrier protein for endogenous and exogenous compounds. Recent studies provide new evidences to support the enzymatic activities of HSA and new molecular insights for such activities. Here, the structural features and enzymatic characteristics of HSA are reviewed.
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Drugs Modulate Allosterically Heme-Fe-Recognition by Human Serum Albumin and Heme-Fe-Mediated Reactivity
Human serum albumin (HSA) represents an important determinant of plasma oncotic pressure and a relevant factor that modulates fluid distribution between the body compartments. Moreover, HSA (i) represents the depot and transporter of several compounds, both endogenous and exogenous, (ii) affects the pharmacokinetics of many drugs, (iii) regulates chemical modifications of some ligands, (iv) shows (pseudo-)e Read More
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Evaluation of Interactions Between Platinum-/Ruthenium-Based Anticancer Agents and Human Serum Albumin: Development of HSA Carrier for Metal-Based Drugs
Authors: Yi Gou, Yao Zhang, Feng Yang and Hong LiangTo date, many potent metal-based anticancer drugs have been developed and many drug delivery systems have been exploited to improve the targeting and decrease the side effects of anticancer drugs. Human serum albumin (HSA) binding contributes significantly to the discovery of new drug candidates because binding of drugs to HSA strongly influences their pharmacokinetic behaviour. Moreover, HSA is widely used in t Read More
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Review: Modifications of Human Serum Albumin and their Binding Effect
Authors: Philbert Lee and Xiaoyang WuHuman serum albumin (HSA) regulates the transport and availability of numerous chemical compounds and molecules in the blood vascular system. While previous HSA research has found that HSA interacts with specific varieties of ligands, new research efforts aim to expand HSA’s ability to interact with more different drugs in order to improve the delivery of various pharmacological drugs. This review will cover fatt Read More
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Recent Advances on the Development of Pharmacotherapeutic Agents on the Basis of Human Serum Albumin
Authors: Fang Liu, Jing Mu and Bengang XingHuman serum albumin (HSA), a major transport protein component in blood plasma, has been reported recently to play many important roles in pharmacotherapeutics development. Owing to its promising intrinsic binding capability of drug molecules, HSA offers favorable characteristics and can be directly used as its monomeric formula or can be fabricated into protein based nanoparticle platforms to realize the effective del Read More
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Molecular Imaging and Targeted Drug Delivery Using Albumin-Based Nanoparticles
Authors: Ji Young Yhee, Jangwook Lee, Hyeyoun Chang, Jeewon Lee, Ick Chan Kwon and Kwangmeyung KimAlbumin has been used as a popular material for carrying imaging probes and/or drugs to provide efficient biomedical imaging and therapy. It is considered as an ideal material for in vivo applications, because albumin is naturally abundant in serum to show non-toxicity and non-immunogenicity. In addition, based on the convenience of chemical modifications, it is widely used for the delivery of diverse molecules i Read More
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Recombinant Human Serum Albumin Fusion Proteins and Novel Applications in Drug Delivery and Therapy
Authors: Brian Rogers, Daoyuan Dong, Zhijun Li and Zhiyu LiFusion proteins have been well-studied and widely applied in biopharmaceutics. Albumin fusion proteins are simple to construct, easy to purify, and stable to formulate. One main application of fusion protein is to extend the plasma half-life of therapeutic proteins and peptides. Albiglutide for diabetes treatment is the first albumin fusion protein drug approved by FDA. Balugrastim and other albumin fusion proteins have been e Read More
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The Advancement of Human Serum Albumin-Based Molecular Probes for Molecular Imaging
Authors: Wei Cao, Xiaoting Lu and Zhen ChengHuman serum albumin (HSA) is an abundant protein in blood and tissue fluids and has been used as a carrier for drug delivery. HSA can improve the pharmacokinetic profiles of drugs, such as extending the blood half-life of existing drugs and reducing toxic side effects. At the same time, more and more molecular imaging probes conjugated or fused with HSA have been studied to achieve higher specificity and better phar Read More
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Volumes & issues
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Volume 31 (2025)
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Volume 30 (2024)
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Volume 29 (2023)
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Volume 28 (2022)
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Volume 27 (2021)
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Volume 26 (2020)
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Volume 25 (2019)
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Volume 24 (2018)
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Volume 23 (2017)
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Volume 22 (2016)
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Volume 21 (2015)
- Issue 42
- Issue 41
- Issue 40
- Issue 39
- Issue 38
- Issue 37
- Issue 36
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- Issue 31
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- Issue 28
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- Issue 22
- Issue 21
- Issue 20
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- Issue 18
- Issue 17
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- Issue 15
- Issue 14
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- Issue 12
- Issue 11
- Issue 10
- Issue 9
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- Issue 7
- Issue 6
- Issue 5
- Issue 4
- Issue 3
- Issue 2
- Issue 1
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Volume 20 (2014)
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Volume 19 (2013)
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Volume 18 (2012)
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Volume 17 (2011)
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Volume 16 (2010)
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Volume 15 (2009)
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Volume 14 (2008)
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Volume 13 (2007)
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Volume 12 (2006)
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Volume 11 (2005)
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Volume 10 (2004)
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Volume 9 (2003)
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Volume 8 (2002)
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Volume 7 (2001)
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Volume 6 (2000)
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