Current Pharmaceutical Analysis - Current Issue

This review article examines the current developments in applying microfluidic technologies in cancer therapy and personalized medicine. This includes the fabrication of cancer cells onto the microfluidic chips, preclinical cancer model simulation development, biomarker detection, tumor heterogeneity detection, integration of microfluidics in robotic drug delivery systems, Artificial Intelligence (AI), and discuss the use of te Read More

BackgroundDoxorubicin (DOX) causes lethal cardiotoxicity, which limits its clinical utility. The molecular mechanisms and effective strategies to combat its cardiotoxicity need further exploration. DT-010, a novel conjugate of danshensu (DSS) and tetramethylpyrazine (TMP), is considered a promising candidate for treating DOX-induced cardiotoxicity. In this study, we aimed to investigate the underlying molecular mechanism Read More

Background and ObjectivesA combination of empagliflozin and linagliptin in a fixed dosage was employed for treating individuals with a diagnosis of type 2 diabetes mellitus. A rapid, accurate, and sensitive liquid chromatography-tandem mass spectrometry method was devised and validated for simultaneous measuring empagliflozin and linagliptin levels in human plasma. This method provides a good analytical tool for bioequival Read More

BackgroundDorzolamide hydrochloride (DRZ) is a carbonic anhydrase inhibitor used to treat glaucoma and ocular hypertension. Drug-eluting contact lenses, such as Acuvue Theravision™ with Ketotifen, offer improved drug delivery and reduced side effects compared to eye drops. Drug-loaded nanoparticle-loaded contact lenses can sustain drug release and enhance comfort for extended wear.ObjectivesHigh buffer conc Read More

BackgroundRapid tablet or capsule dissolution requires the tablet to disintegrate and dissolve at a higher rate, enhancing drug dissolution and bioavailability. Suitable disintegrants have shown an appreciable rate of disintegration or dissolution. Using factorial design for formulation to improve bioavailability is a key focus in pharmaceutical research to enhance dissolution.MethodsAzelnidipine (Azp) tablets were formulat Read More

BackgroundIt is very important to assess the effects of NaOCl and ClO2 on dentine deproteination because these solutions are in contact with dentine during endodontic treatment and may affect the physical and chemical structure of dentine.ObjectivesThis study aimed to analyze the effects of sodium-hypochlorite (NaOCl) and chlorine- dioxide (ClO2) on the chemical structure of human dentine by Attenuated Total Refl Read More

BackgroundDeveloping a simple HPLC method requires an expansive array of literary evidence and experimental routines to perceive the nature of a drug and eventually determine the specific mobile phase and column to be used for attaining better results.ObjectivesThe study aimed to develop and optimize a new, simplified, robust, and sensitive method for the determination of cilostazol in tablets by high-performance liquid chr Read More

BackgroundPirtobrutinib is a novel non-covalent BTK inhibitor used to treat adult patients with relapsed/refractory mantle cell lymphoma and B-cell leukemias. The mechanism of action involves binding and inhibition of Bruton's tyrosine kinase (BTK).ObjectivesThe main goal of the current work was to create a selective liquid chromatographic method (RP-HPLC) that is easy to use, accurate and exact for quantifying Pirtobrutinib Read More

BackgroundSince the International Olympic Committee (IOC) was established, sports doping control analyses have revealed a high rate of positive cases for cannabinoids. Cannabinoids were banned in all sports where they were used in-competition as per the Prohibited List published annually. Further, it was also included in the threshold drug category. Consequently, developing a reliable method for urine Cannabinoids metaboli Read More

BackgroundGardeniae fructus (Zhi-Zi) is the dry ripe fruit of the plant Gardenia jasminoides Ellis (Rubiaceae), which can be used as both food and medicine. Geniposide, a key constituent of Gardeniae fructus, serves as an indicator component for evaluating the quality of Gardeniae fructus. Traditionally, the quantification of geniposide in Gardeniae fructus is achieved through High-performance Liquid Chromatography (HPLC) Read More

BackgroundVildagliptin, Dapagliflozin and Metformin Hydrochloride are anti- hyperglycemic agents. Anti-hyperglycemic agents are drugs that stimulate insulin secretion and lower the glucose level in the blood. They were investigated as a medication for Diabetes Mellitus (DM). Various studies have reported the HPLC, HPTLC, LC/MS methods for the estimation of individuals of VILD, DAPA and METF. However, until date st Read More

AimsThe aim of this study is to develop a sensitive, specific, rapid, and precise reverse-phase high-performance liquid chromatography (RP-HPLC) method and validate it to determine the Roflumilast in rat plasma.BackgroundThis study was aimed at developing a simple HPLC method for the detection of Roflumilast in rat plasma after ingestion of nanoparticles into the rat. A bioanalytical method was developed and validated. Read More

ObjectivesImatinib is a first-line medicine for chronic myeloid leukemia (CML) and gastrointestinal mesenchymal stromal tumors (GIST). Co-administration of nifedipine may lead to drug-drug interactions that affect the clinical efficacy of imatinib. Imatinib and nifedipine are substrates for the cytochrome enzyme CYP3A4. This study aimed to research the pharmacokinetic effect of nifedipine on imatinib and its metabolism Read More