Current Pharmaceutical Analysis - Volume 20, Issue 2, 2024

Various technologies, like flow cytometry and cell sorting, have been established in fields of biomedical research. Fluorescence-activated cell sorting is one of the most powerful techniques to witness advancement in these years. This article aims to provide an in-depth overview of the FACS applications, along with regulatory considerations and qualification parameters for the instrument. Moreover, specifications of instrume Read More

The green synthesis of silver nanoparticles has garnered significant interest because of the unique physicochemical and biological properties they possess. These nanoparticles could have applications in a wide variety of fields, including biomedicine, cellular imaging, cosmetics, healthcare tourism, food and agriculture. The formation of nanoparticles is facilitated by the use of bionanofactories, or green synthesis processes, Read More

Background: Hair analysis plays a crucial role in forensic toxicology, offering a unique medium for long-term drug trace detection. This review emphasizes the evolution of electrochemical methods in analyzing hair for drug traces, underscoring their significance in forensic science. Methods: We examined recent advancements in electrochemical techniques, including voltammetry, amperometry, and electrochemical impedan Read More

Background: Vigabatrin and gabapentin, commonly used antiepileptic drugs in clinics, lack a UV active chromophore and, therefore, require cumbersome derivatization methods for analysis by HPLC using fluorescence detection. This study demonstrated the use of NMR for their quantitative determination in pure form and their pharmaceutical formulations. Objectives: To develop a validated qNMR method for no Read More

Background: Gynostemma pentaphyllum (Thunb.) Makino has been linked to a number of pharmacological benefits, including hepatoprotective, anti-inflammatory, antioxidative, and antihyperlipidemic activities. Gypenoside XLVI (Gyp XLVI) was a significant triterpenoid saponin reported from a sweet-taste varietas G. pentaphyllum, which has inhibitory effects and causes apoptosis on human hepatocytes and hepatoma cells. M Read More

Background: α-phenylethanol and its derivatives are important intermediates for the synthesis of a variety of chiral drugs. Methods: The interaction mechanism of the two enantiomers of α-phenylethanol with β-cyclodextrin (β-CD) was investigated using 1H-NMR and ROESY. The loading of β-CD as the host with the chiral drug intermediate α-phenylethanol as the guest was investigated using high-resolution NMR in D2O and quant Read More