Current Pharmaceutical Analysis - Volume 20, Issue 3, 2024

Ultraviolet-Visible (UV-Vis) spectroscopy has emerged as a powerful analytical tool with diverse applications in pharmaceutical and bio-allied sciences. This article provides a comprehensive overview of the extensive utility of UV-Vis spectroscopy, emphasizing its pivotal role in characterizing and analyzing various compounds critical for drug development and bio-allied research. In the pharmaceutical sector, UV Read More

Background: Salvia species known as "Sage" are among the important aromatic plants used in the world. This study, it was investigated the antioxidant capacity of Salvia cadmica and to investigate its protective effect on oxidative damage in t-BHP-induced fibroblast cells. Methods: Antioxidant activity and phenolic characterization of the extract were evaluated using DPPH, TPC, TFC, FRAP, and HPLC, respectively.TAS Read More

Background: Antiviral drugs can cure more than 95 percent of people with hepatitis C, but the inaccessibility of quality affordable medicines and the lack of their uninterrupted supply poses a major challenge. Impurities in drugs have a significant impact on their quality and are one of the substantial causes of drug recalls, ultimately leading to the unavailability of the drug in the market. Hence, there is a need for a robust, Read More

Background: The Pheretima aspergillum decoction is a traditional therapeutic form, while the formula granules are produced through traditional Chinese medicine decoctions. However, the active ingredients in Pheretima aspergillum have not been fully elucidated, and no published reports have investigated the differences between Pheretima aspergillum decoction and formula granules. Objective: The study aimed to explor Read More

Background: The reverse-phase high-performance liquid chromatography (RP-HPLC) method was developed for the quantitative measurement of monoclonal antibodies (Maftivimab, Atoltivimab, and Odesivimab) in the pharmaceutical dosage form. The Food and Drug Administration (FDA) has approved these monoclonal antibodies for the treatment of Zaire ebolavirus infection in adults. Methods: Maftivimab, Atoltivimab, and O Read More

Objective: Ketamine, commonly known as “K-powder,” is increasingly being abused as a “prom drug.” Palmatine, a typical isoquinoline alkaloid, is mainly found in the roots and stems of natural Chinese herbal medicine plants such as Phellodendron chinense, Coptis chinensis, Sankezhen and Nantianzhu. Herein, we aim to establish a UHPLC-MS/MS method to determine ketamine and palmatine concentrations in rat plasma an Read More