Current Pharmaceutical Analysis - Volume 20, Issue 5, 2024

Many analytical techniques have been used in quality control, such as spectrophotometry, spectrofluorimetry, HPLC, and other hyphenated techniques. Among them, spectrophotometry is considered to be one of the most commonly used simple techniques. Drugs that lack chromogenic groups can be readily determined by using the chromogenic reagents, which react with the functional groups present in the drugs and p Read More

Introduction In this study, a new, simple, selective, and fast liquid chromatographic method has been developed and validated for the determination of imidazolidinyl urea used as an anti-microbial agent in topical formulation. Methods The developed HPLC method using a diode array detector for the determination of imidazolidinyl urea was applied to the topical formulation. Imidazolidinyl urea in the sample was Read More

Background The study focuses on establishing In Vitro Release Testing (IVRT) parameters for Desonide cream, following the guidelines of the Topical Classification System (TCS), to assess the bioequivalence between the Reference Listed Drug (RLD) and test. Aims This study aimed to develop a reliable IVRT method using Franz diffusion cells. An environmentally friendly U-HPLC method was created to analyze Desonide in the sa Read More

Background A combination of fixed-doses containing 0.5 mg lobeglitazone sulfate and 500 mg metformin hydrochloride has demonstrated efficacy in enhancing glycemic control in diabetes. Aims The projected work aimed to establish and validate a high-performance thin-layer chromatographic methodology for the quantification of both drugs in tablet formulations. Objectives The task involves creating and validating a method in Read More

Objectives Mefuparib (CVL218) is one of the second-generation poly-ADP-ribose polymerase (PARP) inhibitors and is used for the treatment of cancer. In this work, the levels of CVL218 in the plasma samples of rats were measured using a newly developed UPLC-MS/MS method. Methods Six rats were given CVL218 (3 mg/kg) orally (po), and another six rats received CVL218 (1 mg/kg) intravenously (iv). Rat plasma samples we Read More

Objectives A detectable innovative fluorimetric method was used to determine omadacycline (OMC) in human plasma matrices, pharmaceutical tablets, and vials with high recovery rates and without biological interference. Methods The fluorimetric technique was used based on the interaction between 4-chloro7-nitrobenzofurazan (NBD-Cl) with a (2-ry amine group) in OMC at pH 8.0, which generates a fluorescent co Read More