Current Pharmaceutical Analysis - Volume 20, Issue 7, 2024

IntroductionInfrared and Raman spectroscopy have emerged as promising diagnostic tools for gastric and liver cancer, offering significant advantages over traditional histology and biomarker-based methods.MethodsThese spectroscopic techniques provide rapid and highly specific molecular fingerprinting with minimal sample preparation, enabling real-time diagnosis and preserving samples for further analysis. The Read More

Remdesivir (RDV) is a nucleoside analogue prodrug that acts as a viral RNA polymerase inhibitor, triggering chain termination following its incorporation. Approved for the treatment of COVID-19 in 2020, RDV is administered intravenously. This article presents the main physicochemical characteristics of the compound and outlines the most relevant pharmacokinetic and pharmacodynamic aspects. The main analytical m Read More

Individual physiological and pathophysiological states, as well as the environment, impact the metabolome. With the help of metabolomics, clinical investigations can better understand the mechanisms underlying disease. The expansion of analytical techniques intended to examine biofluids thoroughly facilitates the characterization of numerous illness biomarkers. Metabolomics aims to identify subtle variances in metabolic p Read More

Introduction/ObjectiveThe current study examines the methodical Quality by Design (QbD) that facilitated the creation of an easy-to-use, quick, affordable, and stability-indicating reversed-phase high-performance liquid chromatography (RP-HPLC) technique for the efficient analysis of aloe-emodin.MethodsThe chromatographic conditions were optimized with the Design Expert software 11.0 version, i.e., flow rate, buffer con Read More

BackgroundFavipiravir is an antiviral drug having pyrazine group moiety. It is a reliable and an efficient green solvent, and a highly recoverable bio-sampling method is required for it. It is widely used in COVID-19 treatment for the prevention of the spread of viral infections in the body.ObjectiveThis proposed green solvent (ionic liquid)-based bioassay study aimed to quantify favipiravir in rat-dried blood spots using Read More

BackgroundPotentilla discolor Bge. is a plant extensively utilized in Traditional Chinese Medicine (TCMs). Nevertheless, our knowledge of the chemical components and metabolic complexities in its extracts is still quite limited.ObjectiveThe study aimed to thoroughly analyze the flavonoid metabolism in Potentilla discolor Bge. extracts and conduct a pharmacodynamic evaluation.MethodsIn this study, we investigated the m Read More

BackgroundThis study investigates the application of polyamidoamine (PAMAM) dendrimers as an innovative drug delivery approach for enhancing the pharmacokinetic profile of ursolic acid (UA), a pentacyclic triterpenoid with multifaceted therapeutic properties. UA, sourced from plants like Sanguisorba officinalis and Salvia officinalis, has been extensively studied for its pharmacological characteristics, including anti-inflamma Read More

PurposeThis paper aims to analyze the clinical distribution and drug resistance changes of Klebsiella pneumoniae (KPN) from 2017 to 2021 in the Beijing Hospital of Integrated Traditional Chinese and Western Medicine to provide a reference for the clinical rational use of antibiotics.MethodsWe collected Klebsiella pneumoniae isolated from various clinical specimens in 2017-2021, analyzed the isolation rate, specimen distribution Read More

BackgroundAzithromycin (AZT), an antimicrobial, despite having a monograph in official compendiums and some methods available in the literature, there is still a demand for eco-efficient methods, which include green analytical chemistry.ObjectivesThis study aimed to develop and validate a green spectrophotometric method for quantifying AZT tablets.MethodsPurified water and ethanol (90:10, v/v) and sulfuric aci Read More

BackgroundQuercetin is a flavanol that has demonstrated pharmaceutical properties such as anti-inflammatory, antioxidant, and anti-carcinogenic properties. However, parenteral formulations of quercetin are currently not in widespread use due to its poor aqueous solubility, fast metabolism, and low bioavailability.ObjectiveThis study aimed to develop a quick, simple, and accurate method for the quantification of quercetin usi Read More

IntroductionAntiretroviral medications are widely used to treat HIV infections. Lamivudine (3TC) is prescribed for HIV-1 infection management in adults and pediatrics, while valganciclovir (VGC) is a prodrug of ganciclovir derived from valine.MethodsThe Biopharmaceutics Classification System (BCS) estimates the contributions of intestinal permeability, dissolution, and solubility in oral drug absorption. Intestinal permeability refe Read More

BackgroundS. barbata D. Don, a perennial herb from the Lamiaceae family, is renowned for its medicinal properties, with scutellarin and scutellarein being key bioactive constituents.AimIn this study, we present the development and validation of a High-Performance Thin-Layer Chromatography (HPTLC) method for the simultaneous quantitative and qualitative analysis of scutellarin and scutellarein in the hydroet Read More

BackgroundConsiderable interest has been devoted to electrochemical sensors for the detection of L-cysteine using BiPr-based oxide-modified electrodes due to high specific surface area and good electro-catalytic activity with several oxidation states. The combination of the BiPr composite oxide nanowires with polyaniline (PAn) can promote the electro-catalytic performance towards L-cysteine because PAn can facilitate the Read More

BackgroundPreservatives called parabens are frequently found in medicinal formulations and personal hygiene products. However, questions have been raised concerning their possible impact on health, leading to the need for reliable methods to determine their presence and degradation of products.ObjectiveThis study aimed to create and validate a straightforward, accurate, dependable, and selective method for determini Read More

ObjectivesDifenidol is widely used in clinical practice due to its good anti-dizziness effect and low side effect rate. This aim was to develop an ultra-high performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method for the selective and straightforward measurement of diphenidol in mouse plasma.MethodsA total of eighteen mice were divided into three groups: six for intravenous administration at a dos Read More