Current Pharmaceutical Analysis - Volume 20, Issue 1, 2024

Nitrosamines are a category of substances that have a nitroso group linked to an amino group in their molecular structure. They are a category of carcinogens developed as a by-product of drug synthesis and also constituted in the presence of sodium nitrite or nitric acid and secondary amines (like dimethyl amines and diethyl amine) that must be monitored in drug production. In mid-June 2018, the Food and Drug Administratio Read More

Background: Highly purified water is essential for the production of pharmaceuticals, directly impacting the quality and safety of the final product. Methods: In this work, we studied the physicochemical and microbiological quality of 1477 purified water samples from 25 compounding pharmacies in Southeast Brazil. To the best of our knowledge, this is the most comprehensive study on the quality of water purified in Br Read More

Objective: This study aimed to establish a simple, reliable, and sensitive method for detecting ketamine, fluoroketamine, and their metabolites in urine using UPLC-MS/MS. Methods: The chromatographic separation was performed on UPLC BEH C18 (50 mm × 2.1 mm, 1.7 μm) at a column temperature of 40°C. The mobile phase consisted of 0.1% formic acid aqueous solution and acetonitrile, with a flow rate set at 0.4 mL/ Read More

Background: Spectrophotometric techniques are based on the absorption of electromagnetic energy by the molecules of the substance analyzed and can be applied to drug analysis. Objective: This study has been proposed to carry out molecular absorption scanning and assay in the ultraviolet region of generic antidepressant drugs of the serotonin reuptake inhibitor class produced by three Brazilian laboratories, addr Read More

Background: Previous studies of dextromethorphan hydrobromide basically worked on simultaneous research with other compounds. So, the development of a novel method using the isocratic elution mode is needed. Objective: For the detection of dextromethorphan hydrobromide (DXM) in diverse matrices, a straightforward, accurate, and sensitive reversed-phase HPLC technique using a Waters 2487 Dual λ Absorbance Read More

Introduction: Indigestion leading to Flatulence is a common problem for infants, and tackling it is tedious for the parents. So, addressing the issue with an ideal formulation should likely have a combination of digestive enzymes and carminatives. Methods: A formulation containing enzymes like Fungal Diastase (Amylase) and Papain (Protease) for the digestion of Carbohydrates and Protein, respectively, along with aromatic, volat Read More

Objective: In order to control the quality better, this study aimed to develop two bioassay methods of Banlangen Granule (BLGG) based on its anti-influenza activity and antiinflammatory activity and to verify the necessity of established methods by relating the results tested by chemical methods. Methods: First, the bioassay methods for determining the biopotency of the anti-influenza effect and anti-inflammatory activity Read More

Objective: The purpose of this study was to develop a UPLC-MS/MS method for the determination of icotinib concentrations in blood plasma. Methods: For plasma sample preparation, protein precipitation with acetonitrile was utilized. Analytes were separated on a Kinetex C18 column using 10 mM ammonium acetate containing 0.2% formic acid and methanol (30:70) as the mobile phase, with a gradient flow rate rangi Read More