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image of Synthesis of Pyridines/Dihydropyridines via Hantzsch Reaction, Structure-activity Relationship and Interactions with Targets: A Review

Abstract

Pyridines/Dihydropyridines is a basic 6-membered organic aza-heterocyclic compound that has garnered the attention of many researchers in recent times. These molecules have been reported with a diverse range of pharmacological activities like anti-coagulant, antileishmanial and anti-trypanosomal, antitubercular agents, anti-microbial, antioxidant, HIV-1 protease inhibitors, anti-cancer, cardiovascular disease, . This review article focuses on different protocols for the Hantzsch reaction using acid catalysts, metal catalysts, and no catalysts for the synthesis of pyridine derivatives. The structure-activity relationship in relation to other biological activities of various pyridine-containing drugs and their interaction with different targets (receptors) has also been highlighted to provide a good understanding to researchers for future research on pyridines.

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2024-10-29
2025-02-17

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Synthesis of Pyridines/Dihydropyridines via Hantzsch Reaction, Structure-activity Relationship and Interactions with Targets: A Review
Bentham Science Publishers ; https://doi.org/10.2174/0113852728331961240918115757
/content/journals/coc/10.2174/0113852728331961240918115757
/content/journals/coc/10.2174/0113852728331961240918115757
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  • Article Type:     Review Article
Keywords: structure activity relationship ; dihydropyridine ; hantzsch reaction ; Pyridine ; biological activity

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