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image of Metal-catalyzed Synthesis of Phenanthrene and its Derivatives: A Core Structure of various Natural Products

Abstract

Phenanthrenes and their dihydro derivatives have attracted considerable attention due to their widespread occurrence in natural products and pharmaceuticals with biological activities, which have led to their application in the treatment of microbial or viral infections, allergies, cancer, and malaria. Nowadays, the transitional metal-catalysed reactions are useful approaches for the synthetic transformation of organic compounds due to high yield and step economy. This approach, owing to the use of non-pre functionalized substrates, minimizes the chemical wastes. Among the various synthetic strategies, metal-catalyzed C-H bond activation and also Heck reactions have recently drawn a lot of interest in synthesizing decorated π-conjugated polycyclic aromatic hydrocarbon. In this review, we have focused on recent progress along with previous strategies to synthesize various phenanthrene and its derivatives by the use of metal-catalyzed reactions and also discussed the mechanistic details of the reaction.

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2025-05-20

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/content/journals/coc/10.2174/0113852728327237241006203431
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Metal-catalyzed Synthesis of Phenanthrene and its Derivatives: A Core Structure of various Natural Products
Bentham Science Publishers ; https://doi.org/10.2174/0113852728327237241006203431
/content/journals/coc/10.2174/0113852728327237241006203431
/content/journals/coc/10.2174/0113852728327237241006203431
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  • Article Type:     Review Article
Keywords: natural products ; aromatic hydrocarbon ; phenanthrene ; polycyclic ; Metal-catalyzed

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