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image of Green Pseudo-Seven Component Synthesis of Tris-cyclohexylamino-oxo-benzene-1,3,5-tricarboxylates via Passerini Reaction under Aqueous Conditions

Abstract

In this study, a simple, mild, and environmentally friendly process was used for the -seven component reaction between readily available benzene-1,3,5-tricarboxylic acid, isocyano-cyclohexane, and various aldehydes. This rapid method produced the tris-cyclohexylamino-oxo-benzene-1,3,5-tricarboxylates in relatively acceptable and more reasonable reaction times (10-15 min) and high achievable efficiencies (85-95%) by employing a Passerini reaction. Water was used as an eco-friendly and low-cost solvent for the green synthesis of benzene tris-carboxamides. The reactions were carried out a Passerini approach at 50ºC for relatively shorter reaction times. The antibacterial action of the synthetic tris-carboxamides was investigated, and some of them gave satisfactory and promising antibacterial results. Target tris-Passerini molecules recrystallized from 96% EtOH. The structures of the resulting molecules were evaluated and confirmed with the help of spectral data and elemental analyses.

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2025-01-02
2025-05-06

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/content/journals/coc/10.2174/0113852728269992241030054239
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Green Pseudo-Seven Component Synthesis of Tris-cyclohexylamino-oxo-benzene-1,3,5-tricarboxylates via Passerini Reaction under Aqueous Conditions
Bentham Science Publishers ; https://doi.org/10.2174/0113852728269992241030054239
/content/journals/coc/10.2174/0113852728269992241030054239
/content/journals/coc/10.2174/0113852728269992241030054239
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  • Article Type:     Research Article
Keywords: green synthesis ; Tris-cyclohexylamino-oxo-benzene-1,3,5-tricarboxylate ; Passerini approach ; antibacterial activity ; aqueous conditions ; Benzene-1,3,5-tricarboxylic acid

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