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Volume 29, Issue 13
  • ISSN: 1385-2728
  • E-ISSN: 1875-5348

Abstract

In this study, a simple, mild, and environmentally friendly process was used for the pseudo-seven component reaction between readily available benzene-1,3,5-tricarboxylic acid, isocyano-cyclohexane, and various aldehydes. This rapid method produced the tris-cyclohexylamino-oxo-benzene-1,3,5-tricarboxylates in relatively acceptable and more reasonable reaction times (10-15 min) and high achievable efficiencies (85-95%) by employing a Passerini reaction. Water was used as an eco-friendly and low-cost solvent for the green synthesis of benzene tris-carboxamides. The reactions were carried out a Passerini approach at 50℃ for relatively shorter reaction times. The antibacterial action of the synthetic tris-carboxamides was investigated, and some of them gave satisfactory and promising antibacterial results. Target tris-Passerini molecules recrystallized from 96% EtOH. The structures of the resulting molecules were evaluated and confirmed with the help of spectral data and elemental analyses.

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2025-06-03

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/content/journals/coc/10.2174/0113852728269992241030054239
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Green Pseudo-seven Component Synthesis of Tris-cyclohexylamino-oxo-benzene-1,3,5-tricarboxylates via Passerini Reaction under Aqueous Conditions
Current Organic Chemistry 29, 1057 (2025); https://doi.org/10.2174/0113852728269992241030054239
/content/journals/coc/10.2174/0113852728269992241030054239
/content/journals/coc/10.2174/0113852728269992241030054239
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  • Article Type:     Research Article
Keyword(s): antibacterial activity; aqueous conditions; benzene-1,3,5-tricarboxylic acid; green synthesis; Passerini approach; Tris-cyclohexylamino-oxo-benzene-1,3,5-tricarboxylate

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