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image of Synthesis, Characterization, and Molecular Docking of Novel Isatin-thiosemicarbazone containing 1,2,3-triazole Derivatives as Potential Anti-cancer Agents

Abstract

To improve the activity of isatin-1,2,3-triazole hybrids as anticancer agents, new derivatives of isatin-thiosemicarbazone-1,2,3-triazoles were designed and synthesized the condensation of isatin-1,2,3-triazole hybrids with thiosemicarbazide. Spectral and elemental analysis confirmed the structure of the prepared derivatives . Also, as anticancer agents, the latter derivatives were screened against three human cancerous cell lines: human lung fibroblast (WI38), colorectal carcinoma colon cancer (HCT-116), and mammary gland breast cancer (MCF-7). , a standard control, was used to compare viable cell percentages and IC50 values. In general, derivatives and revealed a higher potency against the three human cancerous cell lines. Finally, the molecular descriptors of compounds and were correlated with their observed cytotoxicity.

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2024-10-28
2025-04-20

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Synthesis, Characterization, and Molecular Docking of Novel Isatin-thiosemicarbazone containing 1,2,3-triazole Derivatives as Potential Anti-cancer Agents
Bentham Science Publishers ; https://doi.org/10.2174/0113852728332494240919044627
/content/journals/coc/10.2174/0113852728332494240919044627
/content/journals/coc/10.2174/0113852728332494240919044627
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  • Article Type:     Research Article
Keywords: docking of molecules ; anticancer ; 1,2,3-triazole ; thiosemicarbazone ; isatin-thiosemicarbazone-1,2,3-triazole ; Isatin

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