Current Indian Science - Volume 2, Issue 1, 2024

BackgroundOvarian cancer is the most fatal gynecological cancer, with the highest death rate because of its late diagnosis and recurrence. Owing to the inherent drawbacks of conventionally available approaches for ovarian cancer treatment, alternative strategies need to be developed. Recently, nanotechnology-based drug delivery vehicles (polymer, liposome, dendrimers, etc.) have been extensively used in cancer ther Read More

The unique physicochemical properties, low cost, low toxicity, and size- and shape-dependent magnetic properties of the ferrite-based nanoparticles make them an indispensable choice of material for various applications, including catalysis.The objective of this review is to summarize the results of the most widely used ferrite nanoparticles such as NiFe2O4, CuFe2O4, CoFe2O4, ZnFe2O4, and MnFe2O4 as ca Read More

Ubiquitous expression patterns of nuclear hormone and their receptors (NHRs) have their own roles in performing essential functions in controlling hormone responsive element-promoted gene transcription. In diseased states such as cancer, NHRs play crucial roles and hence targeting these receptors are essential as it gives us a window of opportunity for developing targeted anticancer therapeutics. In comparison to traditio Read More

Diabetes Mellitus (DM) is a metabolic syndrome that gradually leads to chronic microvascular or macrovascular complications. There are 2 types of DM: Insulin-dependent diabetes, commonly called type I DM, is an organ-specific autoimmune disorder that destroys the body’s pancreatic β cells, causing insulin deficiency, and can be treated through insulin replacement therapy. Non-insulin-dependent diabetes mellitus, or type II D Read More

BackgroundTinospora cordifolia (TC), commonly referred to as Guduchi, holds a prominent position in the Indian traditional system of medicine and has been cited in Ayurvedic literature for its efficacy in the treatment of a range of ailments, including jaundice, urinary issues, diabetes, prolonged diarrhea, skin conditions, stomachaches, and dysentery.MethodsThe present study analyzed the content of phytochemical markers pres Read More

AimsThe primary aim of this study is to investigate the potential therapeutic effects of Epigallocatechin gallate (EGCG) in a zebrafish model of diabetes induced by streptozotocin.BackgroundDiabetes mellitus is characterized by chronic organ dysfunction and failure. Natural compounds, particularly polyphenols such as EGCG present in green tea, have garnered attention for their potential in managing various complicatio Read More

BackgroundCarissa carandus L., commonly known as Karonda, is renowned for its distinctive tangy flavor, making it a valuable ingredient in culinary applications. Additionally, its extensive array of phytoconstituents renders it a significant component of traditional Indian herbal medicine, where it has been used to address various health conditions. Despite its availability, palatability, and diverse phytochemical profile, Karo Read More

IntroductionThis work investigates the synthesis of self-assembled novel carbo benzyl oxy - L - alanyl - L - valine benzyl ester (CBAVBE).MethodsThorough studies of the morphology, optical, and structural investigations by UV-Visible, UV-DRS, FT-IR, FT-Raman, HR-TEM, and FE-SEM are used to characterize the self-assembled CBAVBE and computational studies also investigated. The anti-oxidant capability of Read More

Catalysis is an integral part of sustainable and green chemical processes. During the last two decades, the wonder 2D carbon material with honeycomb structure, graphene, and other functionalized graphenes have emerged as extremely versatile and robust nanomaterials in heterogeneous catalysis. The incredible catalytic efficacy of such carbon nanomaterials relies on their unique physicochemical propertie Read More

Bacterial and biofilm infections remain a leading cause of global mortality, prompting a shift beyond conventional antibiotic drug development due to the rapid emergence of antimicrobial resistance. This mini-review delves into giving a brief understanding of the realm of metal-containing nanomaterials, emphasizing their potential in antimicrobial phototherapy free from bacterial resistance. The focus extends to transition Read More

BackgroundNephrotoxicity caused by GM is a complicated occurrence that results in a variety of structural and functional changes, including lesions in the glomerular region and proximal tubule damage, which leads to sudden kidney failure. The production of reactive oxygen species (ROS) has also been linked to GM. Acute hepatic impairments caused by medication might lead to rapid deterioration of liver function.ObjectiveThe Read More

Integral membrane proteins are attractive targets for therapeutic intervention due to their crucial roles in cellular functions and their involvement in various diseases. However, targeting these proteins for degradation has posed significant challenges due to their complex structures and diverse functions. The emergence of proteolysis-targeting chimeras (PROTAC) represents a groundbreaking paradigm shift in drug development Read More

Chronic wounds generally take a lot of time to recover, which becomes a cause of worry for the patient and also makes it difficult to manage them. Chronic wound affects the minds of millions of people worldwide, which results in a high mortality rate. Nanomedicine has emerged as a promising tool in addressing this issue of chronic wounds. Nanomedicine in chronic wound healing holds the potential to revolutionize wound care Read More

The review explores the vital dimensions of pharmacovigilance (PV) and adverse drug reaction (ADR) reporting in the healthcare industry, highlighting their importance for public health and patient safety. The review follows the development of PV from its historical beginnings in India, highlighting significant turning points and legislative frameworks that have influenced modern practices. Sibutramine, a well-known med Read More

Oxidation of alcohols in an oxidant-free condition, commonly known as the acceptorless dehydrogenation (AD) reaction, has recently emerged as one of the widely used processes in synthetic organic chemistry. Alcohol acts as an excellent chemical precursor that produces a variety of dehydrogenated value-added products such as carbonyls, acids, acetals, and several coupling products, followed by the concomitant ev Read More

AimThis study aims to explore the binding interactions between synthesized 3,3’-Disubstituted Oxindoles and the HCK enzyme, with the specific goal of discovering potential anticancer agents.BackgroundCancer presents an ongoing global health challenge, necessitating the exploration of innovative therapeutic approaches. Isatin derivatives and pyridine compounds hold great promise for the development of anticancer dr Read More

The technological advances in mass spectrometry and associated computational tools have enabled the development of proteome atlases and comprehensive catalogs of proteome snapshots that have gradually transformed biomedical research. These proteome catalogs in specific biological contexts, which focused initially on model organisms, have now expanded their scope to encompass diverse organisms, tissue Read More