Skip to content
2000
  1. Home
  2. A-Z Publications
  3. Current Indian Science
  4. Volume 2, Issue 1
  5. Article
Volume 2, Issue 1
  • ISSN: 2210-299X
  • E-ISSN: 2210-3007
file format pdf download PDF
side by side viewer icon HTML

Abstract

Background

(TC), commonly referred to as Guduchi, holds a prominent position in the Indian traditional system of medicine and has been cited in Ayurvedic literature for its efficacy in the treatment of a range of ailments, including jaundice, urinary issues, diabetes, prolonged diarrhea, skin conditions, stomachaches, and dysentery.

Methods

The present study analyzed the content of phytochemical markers present in the stems of TC collected from five distinct geographical locations (TC-01 to TC-05) and assessed the corresponding variations in their antioxidant potential.

Results

Lupeol content in various samples of TC varied from 217.9 to 510.9 µg/mg, while palmatine ranged from 0.002% to 0.025%. Total phenolic content (TPC) ranged from 0.77 to 6.35 mg GAE/g wt., and total flavonoid content (TFC) from 12.15 to 20.03 mg QCE/g wt., with IC values between 21.02 and 81.81 mg/mL. Elemental analysis of TC-01 to TC-05 showed significant essential elements and permissible levels of heavy metals. A shelf-life study of TC samples indicated stability beyond three years.

Conclusion

The considerable diversity in phytochemical content and antioxidant values underscores the substantial influence of geographical variation on the therapeutic potential of TC.

© 2024 The Author(s). Published by Bentham Science Publisher.
This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Loading

Article metrics loading...

/content/journals/cis/10.2174/012210299X324745240808062057
2024-08-16
2025-03-01

  • From This Site

    /content/journals/cis/10.2174/012210299X324745240808062057
    dcterms_title,dcterms_subject,pub_keyword
    -contentType:Contributor -contentType:Concept -contentType:Institution
    10
    5
The full text of this item is not currently available.

References

  1. SharmaP. DwivedeeB.P. BishtD. DashA.K. KumarD. The chemical constituents and diverse pharmacological importance of Tinospora cordifolia. Heliyon201959e0243710.1016/j.heliyon.2019.e0243731701036
     [Google Scholar]
  2. RameshV. JayaprakashR. SridharM.P. SasikalaC. Antioxidant activity of ethanolic extract of Tinospora cordifolia on N-nitrosodiethylamine (diethylnitrosamine) induced liver cancer in male Wister albino rats.J. Pharm. Bioallied Sci.2015754010.4103/0975‑7406.15579126015745
     [Google Scholar]
  3. RamamurthyP.H. AgarwalS. FernandesB. RathA. SidhuP. Assessment of antimicrobial activity of different concentrations of Tinospora cordifolia against Streptococcus mutans: An in vitro study.Dent. Res. J. (Isfahan)2019161242810.4103/1735‑3327.24955630745915
     [Google Scholar]
  4. A KhanM. Tinospora cordifolia aqueous extract ameliorates the systemic infection of Aspergillus fumigatus in balb/c mice.Asian J. Pharm. Clin. Res.20191252552810.22159/ajpcr.2019.v12i3.30984
     [Google Scholar]
  5. ShivananjappaM.M. MuralidharaM. Abrogation of maternal and fetal oxidative stress in the streptozotocin-induced diabetic rat by dietary supplements of Tinospora cordifolia. Phytomedicine2011181045105210.1016/j.nut.2011.09.01522189193
     [Google Scholar]
  6. VermaR. ChaudharyH.S. AgrawalR.C. Evaluation of antcarcinogenic and antmutagenic effect of Tinospora cordifolia in experimental animals.J. Chem. Pharm. Res.20113877881Available from: https://www.jocpr.com/abstract/evaluation-of-anti carcinogenic-and-antimutagenic-effect-of-tinospora-cordifolia-in-experimental-animals-880.html
    [Google Scholar]
  7. SarmaD.N.K. KhosaR.L. ChansauriaJ.P.N. SahaiM. Antistress activity ofTinospora cordifoliaandCentella asiaticaextracts.Phytother. Res.1996102181183
     [Google Scholar]
  8. ShanbhagT. ShenoyS. RaoM.C. Wound healing profile of Tinospora cordifolia. Indian Drugs20054221722110.22159/ijpps.2021v13i4.37980
     [Google Scholar]
  9. PrinceP.S.M. MenonV.P. GunasekaranG. Hypolipidaemic action of Tinospora cordifolia roots in alloxan diabetic rats.J. Ethnopharmacol.1998641535710.1016/S0378‑8741(98)00106‑810075122
     [Google Scholar]
  10. KhanM.M. HaqueM.S. ChowdhuryM.S.I. Medicinal use of the unique plant Tinospora cordifolia : Evidence from the traditional medicine and recent research.Asian J. Med. Biol. Res.20172450851210.3329/ajmbr.v2i4.30989
     [Google Scholar]
  11. AliH. DixitS. Extraction optimization of Tinospora cordifolia and assessment of the anticancer activity of its alkaloid palmatine.ScientificWorldJournal20132013137621610.1155/2013/37621624379740
     [Google Scholar]
  12. TheerthagiriJ. ParkJ. DasH.T. RahamathullaN. CardosoE.S.F. MurthyA.P. MaiaG. VoD.V.N. ChoiM.Y. Electrocatalytic conversion of nitrate waste into ammonia: A review.Environ. Chem. Lett.20222052929294910.1007/s10311‑022‑01469‑y
     [Google Scholar]
  13. GautamA.S. SinghA. KumarK. Analysis of therapeutic value of Tinospora cordifolia .Asia Pac. J. Multidiscip. Res.202082741Available from: https://apjmr.com/wp-content/uploads/2020/03/APJMR-2020.8.1.04.pdf
    [Google Scholar]
  14. ChoudharyN. SiddiquiM.B. AzmatS. KhatoonS. Tinospora cordifolia: Ethnobotany, phytopharmacology and phytochemistry aspects.Int. J. Pharm. Sci. Res.201343891899Available from: https://www.researchgate.net/publication/236969021_Tinospora_cordifolia_Ethnobotany_phytopharmacology_and_phytochemistry_aspects
    [Google Scholar]
  15. PantP. PandeyS. Dall’AcquaS. The influence of environmental conditions on secondary metabolites in medicinal plants: A literature review.Chem. Biodivers.20211811e210034510.1002/cbdv.20210034534533273
     [Google Scholar]
  16. BajpaiV. KumarS. SinghA. SinghJ. NegiM.P.S. BagS.K. KumarN. KonwarR. KumarB. Chemometric based identification and validation of specific chemical markers for geographical, seasonal and gender variations in Tinospora cordifolia stem using HPLC-ESI-QTOF-MS analysis.Phytochem. Anal.201728427728810.1002/pca.267328111813
     [Google Scholar]
  17. The ayurvedic pharmacopoeia of India.2016Available from: https://www.ayurveda.hu/api/API-Vol-1.pdf
  18. GandhiY. RawatH. Singh DhanjalD. KumarV. ChardeV. SoniH. MishraS.K. SinghG. SinghS. SharmaP. ShakyaS.K. NarsimhajiC.V. MeenaA.K. SinghA. SinghR. SrikanthN. AcharyaR. A comparative analysis of phytochemicals, metal ions, volatile metabolites in heart wood, stem bark and leaves of Salix alba L. along with invitro antioxidant, antacid, antimicrobial activities for sake of environment conservation by substitution of stem bark with leaf.Chem. Biodivers.20232012e20230123410.1002/cbdv.20230123437867394
     [Google Scholar]
  19. KupinaS. FieldsC. RomanM.C. BrunelleS.L. Determination of total phenolic content using the folin-c assay: Single-laboratory validation, first action 2017.13.J. AOAC Int.201810151466147210.5740/jaoacint.18‑0031
     [Google Scholar]
  20. MatićP. SabljićM. JakobekL. Validation of spectrophotometric methods for the determination of total polyphenol and total flavonoid content.J. AOAC Int.201710061795180310.5740/jaoacint.17‑006628730980
     [Google Scholar]
  21. GandhiY. RawatH. KumarV. ThakurA. MishraS.K. ChardeV. SoniH. SinghG. TandonS. KumarR. ShakyaS.K. JainV. Baboo PrasadS. LaleS.K. AryaJ.C. NarsimhajiC.V. SinghA. SinghR. SrikanthN. AcharyaR. Identification of two kinds of Colchicum corms by DNA barcoding, physicochemical, chromatographic and chemometric analyses along with pharmacognostic parameters.Microchem. J.202319510939910.1016/j.microc.2023.109399
     [Google Scholar]
  22. Sanchez-MorenoC. Review: Methods used to evaluate the free radical scavenging activity in foods and biological systems.Food Sci. Technol. Int.20028312113710.1177/1082013202008003770
     [Google Scholar]
  23. XiaoF. XuT. LuB. LiuR. Guidelines for antioxidant assays for food components.Food front.202011606910.1002/fft2.10
     [Google Scholar]
  24. YuY. MinA. JungH.J. TheerthagiriJ. LeeS.J. KwonK.Y. ChoiM.Y. Method development and mechanistic study on direct pulsed laser irradiation process for highly effective dechlorination of persistent organic pollutants.Environ. Pollut.202129111815810.1016/j.envpol.2021.11815834543953
     [Google Scholar]
  25. AlahmadA. AlghoraibiI. ZeinR. KraftS. DrägerG. WalterJ.G. ScheperT. Identification of major constituents of Hypericum perforatum L. extracts in syria by development of a rapid, simple, and reproducible HPLC-ESI-Q-TOF MS analysis and their antioxidant activities.ACS Omega2022716134751349310.1021/acsomega.1c0633535559140
     [Google Scholar]
  26. BozinB. Mimica-DukicN. SamojlikI. GoranA. IgicR. Phenolics as antioxidants in garlic (Allium sativum L., Alliaceae).Food Chem.2008111492592910.1016/j.foodchem.2008.04.071
     [Google Scholar]
  27. CaiY. LuoQ. SunM. CorkeH. Antioxidant activity and phenolic compounds of 112 traditional Chinese medicinal plants associated with anticancer.Life Sci.200474172157218410.1016/j.lfs.2003.09.04714969719
     [Google Scholar]
/content/journals/cis/10.2174/012210299X324745240808062057
Loading
Phytochemical Marker-based Analysis, Antioxidant Potential, and Shelf-Life Study of Geographically Different Samples of Tinospora cordifolia (Stem)
Curr. Indian Sci. 2, e2210299X324745 (2024); https://doi.org/10.2174/012210299X324745240808062057
/content/journals/cis/10.2174/012210299X324745240808062057
/content/journals/cis/10.2174/012210299X324745240808062057
Loading

Data & Media loading...

Supplements

Supplementary material is available on the publishers' website along with the published article.

file format download Download

  • Article Type:     Research Article
Keyword(s): Antioxidant activity; Geographical variation; Medicinal plants; Palmatine; Phytochemicals; Tinospora cordifolia

Most Cited Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error
Please enter a valid_number test