Current Indian Science - Volume 2, Issue 1, 2024

BackgroundThe creation and development of novel chemical entities is made possible by numerous computer-aided drug design techniques. The ability to visualize the ligand-target interaction and forecast the important holding pocket locations and affinities of ligands to their intended macromolecules is made possible by pharmacophore-based drug design and understanding in-silico methodologies.ObjectiveThe aim of Read More

Tezepelumab is a first-in-class human IgG2λ monoclonal antibody used to treat severe, uncontrolled asthma. Tezepelumab acts by hindering the action of thymic stromal lymphopoietin (TSLP), an epithelial-derived cytokine that triggers an immunological response by binding to TSLP and thereby preventing its binding with the TSLP receptor complex. TSLP has a critical role in Th2 immunity and plays an important role in th Read More

AimThis report discusses two medicinal plants, namely Exallage auricularia (L.) Bremek from Rubiaceae family and Gomphostemma ovatum Wall from Lamiaceae family from Ultapani Reserve Forest of Bodoland Territorial Region (BTR) of Assam, India, are recorded, described, and identified based on their morphological characters, taxonomical notes, phenology, and field photos along with map of distribution.MethodsThe loc Read More

At present, there is a growing interest among researchers in studying the structure and function of the bee brain in relation to their cognitive behavior. The bee brain, despite its small size of approximately 1 million neurons, is known for its ability to facilitate effective communication and collaboration. Just like humans, the bee brain is also controlled by biogenic amines like dopamine, serotonin and tyramine, octopamine, Read More

Diabetes Mellitus (DM) is a compounded, persistent illness symbolized by an increased range of glucose levels in the blood caused by cellular resistance to insulin action, insufficient insulin production by pancreatic -cells, or both. Type 1 Diabetes Mellitus (T1DM), the extremely widespread form of DM, is recorded for almost 85-90% of worldwide cases. T2DM is mostly common in middle-aged and older people, and its cause Read More

The pharmaceutical industry is witnessing a growing demand for complex generic products, which are generic versions of drugs that possess complex formulations, delivery systems, or active ingredients. However, the approval process for these complex generic products poses unique challenges compared to traditional generics. There is no specific regulatory procedure available for the approval of complex generics, u Read More

The nutritional and therapeutic potential of medicinal plants is constantly being investigated. This is especially relevant in today's world, where an increasing number of people are turning to complementary and alternative therapies to address their health-related concerns. Traditional knowledge, as a valuable resource, plays a crucial role in the development of new herbal medicines. Abroma augusta stands out as one Read More

AimThis review has examined and organized the available research on dementia medication care costs. Although the accessible database in this area is growing and is still quite limited, there are many clear scientific methods.ObjectiveThe use of Memantine, a non-competitive antagonist with low to moderate affinity for the NMDA (N-methyl-D-aspartate) receptor, has been approved for the treatment of mild to moderately sev Read More

The cellular and biochemical stages of the wound-healing process are interrelated and work to repair the wound. The body heals wounds in stages, and each stage that is postponed raises the risk of microbial infection. The time needed for healing can be sped up, and unwanted events can be reduced to improve wound healing. To aid in the healing of the wounds, the medications are administered locally or systemically. In orde Read More

BackgroundComputers play a vital role in people's lives because of their great precision, speed, and accuracy, as well as their ability to provide timely updates. A cascade of ocular and extraocular symptoms in computers or electronics leads to Computer Vision Syndrome. Ergonomics is the science of fitting job demands and workplace environments to the capabilities of the population. The use of a computer increases the ris Read More

BackgroundA nanostructured lipid carrier (NLC) is a nanoparticulate carrier system consisting of solid lipids, liquid lipids, surfactants, and water. NLCs are second-generation lipid nanocarriers, gained continuous significance in recent times, and possess better physical stability, increased drug loading, improved permeability, and bioavailability. They are considered superior to many other traditional lipid-based nanocarriers such Read More

IntroductionThe present study reveals the 2D, 3D-QSAR analysis of Thieno[3,2-d]pyrimidine to expressed the biological activity against Cholesterol, structurally different ligands can fit to common receptor site and safety consideration of the said chemical entities are good describe by Pharmacophore models.MethodsThe organic exercises of the atoms were changed over into log IC50. The measurably significant of 2D- Read More

Digitalis purpurea L. belongs to the Scrophulariaceae family. The most significant is digitoxin, a very toxic substance that builds up in the body and is impenetrable in water. For millennia, people have utilized the medication Digitalis to treat cardiac problems induced by obesity. External triggers like strenuous exercise, emotional stress, eating, exposure to extreme weather, sexual activity, coffee and alcohol consumption, and use of Read More

A chronic skin condition called psoriasis can manifest as plaque, flexural, guttate, pustular, and erythrodermic lesions, among other clinical symptoms. Sixty million people are believed to be affected by psoriasis worldwide. In India, the frequency ranges from 0.44 to 2.8%, with males affected two times more frequently than females in their third or fourth decade of life. An immune-mediated inflammation condition wit Read More

BackgroundCritical monitoring of moisture content in annulus gas is required due to its detrimental effect on the pressure tube, leading to surface corrosion and finally the rupture of the pressure tube.Methods and ResultsThe present work describes a simple and reliable thermo-analytical method for the quantitative determination of moisture in CO2 gas cylinders, using anhydrous barium chloride as the novel adsorbent m Read More

Introduction: Nanoencapsulation has gained popularity in recent decades due to its numerous benefits, such as improved stability, oxidation resistance, retention of volatile ingredients, controlled release, delivery of multiple active ingredients in a row, improvement in organoleptic properties, reduction of toxic side effects, and water solubility.Methods: The present study was aimed to prepare eugenol nanoemulsions Read More

API analysis plays an important role in nourishing the quality, safety, efficacy, and potency of bulk drugs and pharmaceutical formulations. Increased drug products in the market lead to increased demand for new analytical techniques for Active Pharmaceutical Ingredient (API) analysis. During the past decades, method developments were necessitated for drug impurities, excipient profiling, and testing for biopharmaceu Read More