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Volume 1, Issue 1
  • ISSN: 2210-299X
  • E-ISSN: 2210-3007
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Abstract

Background

The use of medicinal plants is vital in the treatment of several ailments. Litchi (.) fruit pericarp is the main by-product of litchi processing. Litchi fruit pericarp contains a significant amount of polyphenolic compounds, which have been found to have a broad variety of biological activities.

Methods

Litchi pericarp was produced in 10% (w/w) hydrogel and tested for wound healing activities in Wistar rats using an excision wound model. Wound healing activity was evaluated using wound-healing rate, inflammatory cytokine levels, oxidative stress, collagen hydroxyproline and hexosamine concentration, and macroscopic and histological evidence.

Results

The results show that pericarp extract has significant wound healing potential, which is indicated by better wound closure, tissue regeneration, and histological characteristics. Litchi pericarp hydrogel boosted the skin's hydroxyproline content, antioxidant capacity, wound contraction, and anti-inflammatory potential by regulating the production of the cytokines TNF-α, IL-1β, and IL-6. This supports the effectiveness of litchi pericarp's wound-healing qualities.

Conclusion

Litchi pericarp hydrogel promoted wound recovery in rats, encouraging its application in wound alleviation.

© 2024 The Author(s). Published by Bentham Science Publisher.
This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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2023-10-06
2024-12-28

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/content/journals/cis/10.2174/2210299X01666230808152705
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Harnessing the Potential of Litchi Fruit Pericarp for Wound Mitigation in Wistar Albino Rats
Curr. Indian Sci. 1, E080823219531 (2023); https://doi.org/10.2174/2210299X01666230808152705
/content/journals/cis/10.2174/2210299X01666230808152705
/content/journals/cis/10.2174/2210299X01666230808152705
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  • Article Type:     Research Article
Keyword(s): Cytokines; Excisional wound; Hydrogel; Hydroxyproline; Litchi pericarp; Rats

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