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Volume 2, Issue 1
  • ISSN: 2210-299X
  • E-ISSN: 2210-3007
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Abstract

Background

Nephrotoxicity caused by GM is a complicated occurrence that results in a variety of structural and functional changes, including lesions in the glomerular region and proximal tubule damage, which leads to sudden kidney failure. The production of reactive oxygen species (ROS) has also been linked to GM. Acute hepatic impairments caused by medication might lead to rapid deterioration of liver function.

Objective

The purpose of this study was to evaluate the suspension of nuts of at a lower dose (800 mg/kg, b.w.) and a higher dose (1600 mg/kg, b.w.) for nephroprotective and hepatoprotective activities.

Materials and Methods

Drug-induced nephrotoxicity and drug-induced hepatotoxicity models were used to evaluate the nephroprotective and hepatoprotective activity using albino mice. A histopathological study was also performed.

Results

Suspension of nuts exhibited significant nephroprotective and hepatoprotective activity. Suspension of nuts from higher dose (1600 mg/kg b.w showed higher nephroprotective and hepatoprotective activity compared to the lower dose (800 mg/kg). The nephroprotective activity was evident by decreased serum creatinine, uric acid, serum urea, and BUN, which were confirmed by histological study. The hepatoprotective effect was confirmed by significantly decreased serum alanine transaminase (ALT), aspartate transaminase (AST), alkaline phosphatase (ALP), total protein, and total bilirubin levels in treated groups, which were further confirmed by histopathological study.

Conclusion

The result suggests that possesses nephroprotective and hepatoprotective activities.

© 2024 The Author(s). Published by Bentham Science Publisher.
This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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2024-11-06
2025-03-01

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/content/journals/cis/10.2174/012210299X319204240918054725
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Therapeutic Effectiveness of Prunus dulcis for Nephroprotective and Hepatoprotective in Albino Mice
Curr. Indian Sci. 2, e2210299X319204 (2024); https://doi.org/10.2174/012210299X319204240918054725
/content/journals/cis/10.2174/012210299X319204240918054725
/content/journals/cis/10.2174/012210299X319204240918054725
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  • Article Type:     Research Article
Keyword(s): Acute hepatic impairments; Hepatoprotective; Nephroprotective; Nephrotoxicity; Prunus dulcis; Serum creatinine

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