Skip to content
2000
  1. Home
  2. A-Z Publications
  3. Current Indian Science
  4. Volume 2, Issue 1
  5. Article
Volume 2, Issue 1
  • ISSN: 2210-299X
  • E-ISSN: 2210-3007
file format pdf download PDF
side by side viewer icon HTML

Abstract

Background

A nanostructured lipid carrier (NLC) is a nanoparticulate carrier system consisting of solid lipids, liquid lipids, surfactants, and water. NLCs are second-generation lipid nanocarriers, gained continuous significance in recent times, and possess better physical stability, increased drug loading, improved permeability, and bioavailability. They are considered superior to many other traditional lipid-based nanocarriers such as nanoemulsion, liposomes, and solid lipid nanoparticles (SLN) and have emerged as an alternative to first-generation nanoparticles (SLN). NLCs have significant potential in the pharmaceutical industry due to their extensive beneficial effects, like drug targeting, enhanced bioavailability, and their wide positive benefits.

Objective

The primary aim of this review was to study and explore the Nano lipid carrier, its advantages, patent preferences, and advancement of NLCs use in nose-to-brain drug delivery.

Methods

The objective of this study was to conduct a literature review on the development of NLC for nose-to-brain drug delivery. The review focused on NLC, its significant role in nose-to-brain delivery, and relevant patents. To achieve this goal, different review articles searched, were studied, and summarized from various sources such as research articles, review articles, books, scientific reports, and patents.

Conclusion

This review article discusses the potential benefits of NLCs in brain-targeting drug delivery through the intranasal route and key aspects of NLCs, including their structure composition, formulation technique, and characterization, which are crucial for developing a reliable drug delivery.

© 2024 The Author(s). Published by Bentham Science Publisher.
This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Loading

Article metrics loading...

/content/journals/cis/10.2174/012210299X260333231120025251
2023-12-13
2025-03-01

  • From This Site

    /content/journals/cis/10.2174/012210299X260333231120025251
    dcterms_title,dcterms_subject,pub_keyword
    -contentType:Contributor -contentType:Concept -contentType:Institution
    10
    5
The full text of this item is not currently available.

References

  1. LeeD. MinkoT. Nanotherapeutics for nose-to-brain drug delivery: An approach to bypass the blood-brain barrier.Pharmaceutics20211312204910.3390/pharmaceutics1312204934959331
     [Google Scholar]
  2. SelvarajK. GowthamarajanK. KarriV.V.S.R. Nose to brain transport pathways an overview: potential of nanostructured lipid carriers in nose to brain targeting.Artif. Cells Nanomed. Biotechnol.20174681810.1080/21691401.2017.142007329282995
     [Google Scholar]
  3. KumarM. MisraA. BabbarA.K. MishraA.K. MishraP. PathakK. Intranasal nanoemulsion based brain targeting drug delivery system of risperidone.Int. J. Pharm.20083581-228529110.1016/j.ijpharm.2008.03.02918455333
     [Google Scholar]
  4. SavaleS. MahajanH. Nose to Brain: A versatile mode of drug delivery system.Asian J. Biomater. Res.2017311638
     [Google Scholar]
  5. WermelingDP System and method for intranasal administration of lorazepam.US Patent 0055571A12001
  6. WermelingDP System and method for intranasal administration of lorazepam.US Patent 6610271B22003
  7. ChoiYM KimKH Transnasal microemulsions containing diazepam.WO Patent 04110403A12004
  8. ChoiYM KimKH Transnasal microemulsions containing diazepam.US Patent 0002987A12005
  9. MisraA VyasTK Drugs loaded nasoadhesive microemulsions for brain targeted brisk delivery in acute epilepsy.Patent 1061/MUM/20042005
  10. MisraA VyasTK Sedatives loaded intranasal nasoadhesive microemulsions for brain targeted delivery in insomnia.Patent 1124/MUM/20042005
  11. MisraA VyasTK Drugs loaded intranasal nasoadhesive microemulsions for brain targeted delivery in migraine.Patent 1125/MUM/20042005
  12. FrenkelD MaronR BurtD WeinerHL Compositions and methods for treating neurological disorders.US Patent 0229233A12006
  13. CastileJD ChengYH JenkinsPG Intranasal compositions.US Patent 0140981A12007
  14. MukherjeeS. RayS. ThakurR.S. Solid lipid nanoparticles: A modern formulation approach in drug delivery system.Indian J. Pharm. Sci.200971434935810.4103/0250‑474X.5728220502539
     [Google Scholar]
  15. AbdellatifA.A.H. AlsowineaA.F. Approved and marketed nanoparticles for disease targeting and applications in COVID-19.Nanotechnol. Rev.20211011941197710.1515/ntrev‑2021‑0115
     [Google Scholar]
  16. ElmowafyM. Al-SaneaM.M. Nanostructured lipid carriers (NLCs) as drug delivery platform: Advances in formulation and delivery strategies.Saudi Pharm. J.2021299999101210.1016/j.jsps.2021.07.01534588846
     [Google Scholar]
  17. GargJ. PathaniaK. SahS.P. PawarS.V. Nanostructured lipid carriers: A promising drug carrier for targeting brain tumours.Future J. Pharm. Sci.2022812510.1186/s43094‑022‑00414‑8
     [Google Scholar]
  18. AhmadJ. RizwanullahM. AminS. WarsiM.H. AhmadM.Z. BarkatM.A. Nanostructured Lipid Carriers (NLCs): Nose-to-brain delivery and theranostic application.Curr. Drug Metab.202021141136114310.2174/138920022166620071900330432682366
     [Google Scholar]
  19. PatidarA. ThakurD.S. KumarP. VermaJ. A review on novel lipid based nanocarriers.Int. J. Pharm. Pharm. Sci.2010243035
     [Google Scholar]
  20. TejK.V.M.S. MoinA. GowdaD.V. KarunakarG. PatelN.P. KamalS.S. Nanostructured lipid carrier-based drug delivery system.J. Chem. Pharm. Res.201682627643
     [Google Scholar]
  21. JaiswalP. GidwaniB. VyasA. Nanostructured lipid carriers and their current application in targeted drug delivery.Artif. Cells Nanomed. Biotechnol.2016441274010.3109/21691401.2014.90982224813223
     [Google Scholar]
  22. AmitS. AshishB. Nanostructured Lipid Carriers: A review.J. Dev. Drugs20187111210.4172/2329‑6631.1000191
     [Google Scholar]
  23. kaurS. NautyalU. SinghR. SinghS. DeviA. Nanostructure Lipid Carrier (NLC): the new generation of lipid nanoparticles.Asian Pac. J. Health Sci.201522769310.21276/apjhs.2015.2.2.14
     [Google Scholar]
  24. ChandanaK.V. GuptaN.V. KannaS. Nanostructured lipid carriers: The frontiers in drug delivery.Asian J. Pharm. Clin. Res.201912781210.22159/ajpcr.2019.v12i7.33595
     [Google Scholar]
  25. ChauhanI. YasirM. VermaM. SinghA.P. Nanostructured lipid carriers: A ground breaking approach for Transdermal drug delivery.Adv. Pharm. Bull.202010215016510.34172/apb.2020.02132373485
     [Google Scholar]
  26. HungL.C. BasriM. TejoB.A. IsmailR. NangH.L.L. HassanH.A. MayC.Y. An improved method for the preparations of nanostructured lipid carriers containing heat-sensitive bioactives.Colloids Surf. B Biointerfaces201187118018610.1016/j.colsurfb.2011.05.01921652183
     [Google Scholar]
  27. PatilN.L. MahajanH.S. Quercetin loaded nanostructured lipid carriers for nose to brain delivery: in vitro and in vivo studies.Am. J. Adv. Drug Deliv.201860100902010.21767/2321‑547X.1000022
     [Google Scholar]
  28. PraveenS. GowdaD.V. SrivastavaA. OsmaniR. Formulation and evaluation of Nanostructured Lipid Carrier (NLC) for Glimperide.Pharm. Lett.201687251256
     [Google Scholar]
  29. EmanetM. ŞenÖ. PignatelliF. LavarelloC. PetrettoA. CiofaniG. Hazelnut extract-loaded nanostructured lipid carriers and evaluation of their antioxidant properties.Front. Bioeng. Biotechnol.20221095386710.3389/fbioe.2022.95386735992355
     [Google Scholar]
  30. LinY.K. HuangZ.R. ZhuoR.Z. FangJ.Y. Combination of calcipotriol and methotrexate in nanostructured lipid carriers for topical delivery.Int. J. Nanomedicine2010511712820309398
     [Google Scholar]
  31. AhmadA. AbuzinadahM.F. AlkreathyH.M. BanaganapalliB. MujeebM. Ursolic acid rich Ocimum sanctum L leaf extract loaded nanostructured lipid carriers ameliorate adjuvant induced arthritis in rats by inhibition of COX-1, COX-2, TNF-α and IL-1: Pharmacological and docking studies.PLoS One2018133e019345110.1371/journal.pone.019345129558494
     [Google Scholar]
  32. MasjediM. AzadiA. HeidariR. Mohammadi-SamaniS. Nose-to-brain delivery of sumatriptan-loaded nanostructured lipid carriers: preparation, optimization, characterization and pharmacokinetic evaluation.J. Pharm. Pharmacol.202072101341135110.1111/jphp.1331632579251
     [Google Scholar]
  33. PiazziniV. LemmiB. D’AmbrosioM. CinciL. LuceriC. BiliaA. BergonziM. Nanostructured lipid carriers as promising delivery system for plant extracts: The case of silymarin.Appl. Sci.201887116310.3390/app8071163
     [Google Scholar]
  34. YuanH. WangL.L. DuY.Z. YouJ. HuF.Q. ZengS. Preparation and characteristics of nanostructured lipid carriers for control-releasing progesterone by melt-emulsification.Colloids Surf. B Biointerfaces200760217417910.1016/j.colsurfb.2007.06.01117656075
     [Google Scholar]
  35. YuS. TanG. LiuD. YangX. PanW. Nanostructured lipid carrier (NLC)-based novel hydrogels as potential carriers for nepafenac applied after cataract surgery for the treatment of inflammation: design, characterization and in vitro cellular inhibition and uptake studies.RSC Advances2017727166681667710.1039/C7RA00552K
     [Google Scholar]
  36. PugliaC. SarpietroM.G. BoninaF. CastelliF. ZammataroM. ChiechioS. Development, characterization, and in vitro and in vivo evaluation of benzocaine- and lidocaine-loaded nanostructrured lipid carriers.J. Pharm. Sci.201110051892189910.1002/jps.2241621374621
     [Google Scholar]
  37. KhosaA. ReddiS. SahaR.N. Nanostructured lipid carriers for site-specific drug delivery.Biomed. Pharmacother.201810359861310.1016/j.biopha.2018.04.055
     [Google Scholar]
  38. JavedS. ManglaB. AlmoshariY. SultanM.H. AhsanW. Nanostructured lipid carrier system: A compendium of their formulation development approaches, optimization strategies by quality by design, and recent applications in drug delivery.Nanotechnol. Rev.20221111744177710.1515/ntrev‑2022‑0109
     [Google Scholar]
  39. JN. KarriV.V.S.R. Anindita De. Nanostructured lipid carrier (NLC): A promising drug delivery system.GJN201715001200012510.19080/GJN.2017.01.555575
     [Google Scholar]
  40. GowdaD.V. TejK.V.M.S. MoinA. Nano structured lipid carrier based drug delivery system.J. Chem. Res.201682627643
     [Google Scholar]
  41. WongH.L. LiY. BendayanR. RauthM.A. WuX.Y. Solid lipid nanoparticles for anti-tumor drug delivery. AmijiMM Nanotechnology for Cancer TherapyBoca RatonCRC press, Taylor & Francis Group2007
     [Google Scholar]
  42. IqbalM.A. MdS. SahniJ.K. BabootaS. DangS. AliJ. Nanostructured lipid carriers system: Recent advances in drug delivery.J. Drug Target.2012201081383010.3109/1061186X.2012.71684522931500
     [Google Scholar]
  43. ShahN.V. SethA.K. BalaramanR. AundhiaC.J. MaheshwariR.A. ParmarG.R. Nanostructured lipid carriers for oral bioavailability enhancement of raloxifene: Design and in vivo study.J. Adv. Res.20167342343410.1016/j.jare.2016.03.00227222747
     [Google Scholar]
  44. SchillerR. WeissC.K. LandfesterK. Phase stability and photocatalytic activity of Zr-doped anatase synthesized in miniemulsion.Nanotechnology2010214040560310.1088/0957‑4484/21/40/40560320829575
     [Google Scholar]
  45. KumarM. Amandeep BhattS. DeviS. UpadhyayP.K. SainiV. MittalA. MehanN. SainiA. Recent advances in the development of the nanostructured lipid carriers for the topical fungal infections.J. Rep. Pharm. Sci.20209227127810.4103/jrptps.JRPTPS_99_19
     [Google Scholar]
  46. LooCh. BasriM. IsmailR. LauH. TejoB.A. KanthimathiM.S. HassanH. ChooY. Effect of compositions in nanostructured lipid carriers (NLC) on skin hydration and occlusion.Int. J. Nanomedicine20128132210.2147/IJN.S3564823293516
     [Google Scholar]
  47. LuG.W. GaoP. Emulsions and micro emulsions for topical and transdermal drug delivery.Handbook of Non-Invasive Drug Delivery Systems.1st ed KulkarniV.S. UKWilliam Andrew201010.1016/B978‑0‑8155‑2025‑2.10003‑4
     [Google Scholar]
  48. SubramaniamB. SiddikZ.H. NagoorN.H. Optimization of nanostructured lipid carriers: understanding the types, designs, and parameters in the process of formulations.J. Nanopart. Res.202022614110.1007/s11051‑020‑04848‑0
     [Google Scholar]
  49. UpritS. Kumar SahuR. RoyA. PareA. Preparation and characterization of minoxidil loaded nanostructured lipid carrier gel for effective treatment of alopecia.Saudi Pharm. J.201321437938510.1016/j.jsps.2012.11.00524227958
     [Google Scholar]
  50. MadaneR.G. MahajanH.S. Curcumin-loaded nanostructured lipid carriers (NLCs) for nasal administration: design, characterization, and in vivo study.Drug Deliv.20162341326133410.3109/10717544.2014.97538225367836
     [Google Scholar]
  51. ImranM. ShahM.R. UllahS. Lipid-Based Nanocarriers for Drug Delivery and Diagnosis.UKElsevier2017
     [Google Scholar]
  52. KuntscheJ. HorstJ.C. BunjesH. Cryogenic transmission electron microscopy (cryo-TEM) for studying the morphology of colloidal drug delivery systems.Int. J. Pharm.20114171-212013710.1016/j.ijpharm.2011.02.00121310225
     [Google Scholar]
  53. AhmadJ. Lipid nanoparticles based cosmetics with potential application in alleviating skin disorders.Cosmetics2021838410.3390/cosmetics8030084
     [Google Scholar]
  54. KaulS. GulatiN. VermaD. MukherjeeS. NagaichU. Role of nanotechnology in cosmeceuticals: A review of recent advances.J. Pharm.2018201811910.1155/2018/342020429785318
     [Google Scholar]
  55. PuriD. BhandariA. SharmaP. ChoudharyD. Lipid nanoparticles (SLN, NLC): A novel approach for cosmetic and dermal pharmaceutical.Int. J. of Pharm. Life Sci.20167951775184
     [Google Scholar]
  56. FoxCB KhandharAP VanH.N ErasmusJG LinSS. Nanostructured lipid carriers and stable emulsions and uses thereof.EP Patent 36382072020
  57. PathaniaA KumarM SarupP BhattS PanduranganA SainiV Novel nanostructured lipid carrierbased ophthalmic controlled release formulation for treatment in fungal keratitis.Patent IN2018110212132019
  58. SarmidiMR MohamadST HashamR A nanostructured lipid carrier encapsulates bromelain extract.MYPI Patent 20183000012019
  59. BehlG KumariS Ocular drug delivery.WO Patent 2019123420A12019
  60. WangB WangQ BaiL. A kind of polymer thermal sensitive liposome loading yeast dextran and carnosic acid.CN Patent 1089044502018
  61. HashamR SuhaimiSH RosliNA AzizR SarmidiMR A nanostructured lipid carrier encapsulates orthosiphon stamineus extract.MYPI Patent 20163000232018
  62. AzizR SabtuR ArifffinFD RosliNA AzizA.A HashamRA. Nanostructured lipid carrier encapsulates zingiber officinale oil.MYUI Patent 20150026952017
  63. HamidrezaK. MajidS. Topical nanodrug formulation.US Patent 201700208962017
  64. WangS ZhangY YinL LiangZ Hydrophilic modification asiatic acid nanostructured lipid carrier and preparation method thereof.CN Patent 1059199762016
  65. KaurIP KakkerS SinglaA Nanostructured lipidic-polymeric pharmaceutical composition encapsulating drugs.Patent IN2074/DEL/20142016
  66. SalunkheSS BhatiaNM BhariaMS Idebenone lipid nanocarrier composition for the treatment of neurodegenerative disorders.Patent IN276/MUM/20142015
  67. TiangeC YuC FengdeT. Psoralen-doxorubicin-loaded composite nanostructured lipid carrier preparation and preparation method thereof.CN Patent 104367549A2015
  68. KangZ. Podophyllotoxin preparation resisting condyloma acuminata relapse and HPV latent infection. Nanfang Hospital of Southern Medical University.CN Patent 103893167A2014
  69. YazanLS KeatNW AbdullahR WunHC Thymoquinone loaded nanostructured lipid carriers (TQNLC) and uses thereof.MYPI Patent 20120018182013
  70. KaurSK ChetanPM Nanotechnology based herbal composition for safe and effective treatment of psoriasis.Patent IN422/MUM/20112013
  71. QiangX XueyangD Composite anti-screening agent nanostructured lipid carrier and preparation method thereof.CN Patent 102688152A2012
  72. QiangX WujunZ Resveratrol nanostructured lipid carrier and preparation method thereof.CN Patent 1026140912012
  73. KadamVT NanjwadeBK Nanostructured lipid carrier (NLC) drug delivery systems for treatment of neurodegenerative disorders.Patent IN1251/MUM/20122012
  74. IsmalR HungL.C NangHLL MayCY BasriM.B TejoBA. Method for preparing a nanostructured lipid carrier and a product manufactured by the same.KR Patent 10201101372632011
  75. DianruiZ LejiaoJ HuilingC CunxianD YancaiW FeifeiF Silybin nanostructured lipid barrier preparation method thereof.CN Patent 1016326382010
  76. QiangX HongxiaW. Coenzyme Q nano structured lipid carrier and preparation method thereof.CN Patent 101658468B2010
  77. QiangX JiayingW Azithromycin nano structured lipid carrier and preparation method thereof.CN Patent 1016584932010
/content/journals/cis/10.2174/012210299X260333231120025251
Loading
Nano Lipid Carriers: A Novel Approach for Nose to Brain Drug Delivery
Curr. Indian Sci. 2, E2210299X260333 (2024); https://doi.org/10.2174/012210299X260333231120025251
/content/journals/cis/10.2174/012210299X260333231120025251
/content/journals/cis/10.2174/012210299X260333231120025251
Loading

Data & Media loading...


  • Article Type:     Review Article
Keyword(s): Bioavailability; Liquid lipids; Nanocarriers; NLC; Patents; Solid lipids

Most Cited Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error
Please enter a valid_number test