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Current Cardiology Reviews - Online First
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18
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Trends in Readmissions Rates and Mortality after Cardiac Resynchronization Therapy in Patients with Nonischemic Cardiomyopathy
Available online: 03 March 2025More LessIntroduction Advances in cardiac implanted electronic devices (CIED) have significantly improved outcomes for patients with heart failure. However, there is a bereft of recent real-world data on the relative effectiveness of cardiac resynchronization therapy with pacing and defibrillator (CRT-D) and continuous resynchronization therapy with pacing (CRT-P) in patients with nonischemic cardiomyopathy (NICM). We hypothesized th Read More
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Non-Bacterial Thrombotic Endocarditis in Lung Cancer: A Systematic Review
Available online: 11 February 2025More LessIntroduction Nonbacterial Thrombotic Endocarditis (NBTE) is a rare condition characterized by aseptic vegetations of the heart valves, predisposing to valvular dysfunction and end-organ infarction. Lung Cancer (LC) is amongst the most common malignancies associated with NBTE. Methods PubMed/MEDLINE was searched from database inception until January 2024, pairing “Non-Bacterial Thrombotic Endocarditis (NBTE) and Read More
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The Impact of Novel Lipid-Lowering Agents on Cardiovascular Risk Reduction: A Systematic Review and Meta-Analysis
Available online: 11 February 2025More LessIntroduction Reducing the risk of atherosclerotic cardiovascular disease is the aim of lipid-lowering therapy (ASCVD). It is commonly acknowledged that low-density lipoprotein (LDL) is a major cause of ASCVD. Several online databases and search engines, such as PubMed and the Cochrane Library, were used to conduct a thorough search. Method This study included RCTs assessing the effect of PCSK9 inhibitors on cardiovas Read More
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The Role of Red Blood Cells in Cholesterol Accumulation and Atherosclerotic Plaque Instability: A Perspective on Atherosclerosis
Authors: Reza Mohebbati and Mohammad Amin Momeni MoghaddamAvailable online: 11 February 2025More LessAtherosclerosis stands as the primary cause of CVD, characterized by the accumulation of cholesterol deposits within macrophages in medium and large arteries. This deposition promotes the proliferation of specific cell types within the arterial wall, gradually narrowing the vessel lumen and impeding blood flow. Intra-plaque hemorrhages are recognized as critical events in atherosclerotic plaques, leading to the deposition of Read More
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Effects of Physical Exercise and the Use of Doxorubicin on Cardiac Function in Rodents: A Systematic Review and Meta-Analysis
Available online: 10 February 2025More LessBackground Anthracycline-based chemotherapy, such as Doxorubicin (DOX), often induces cardiotoxicity in cancer patients, which compromises their health and quality of life. Objective This study aimed to verify the effects of exercise concomitant with prolonged administration of DOX on improving cardiotoxicity. Methods: A systematic literature search in MedLine, PubMed, Web of Science, and Scopus databases was perfo Read More
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The Use of Veno-Arterial Extracorporeal Membrane Oxygenation (VA-ECMO) for Acute High Risk Pulmonary Embolism: A Systematic Review
Authors: Rohit Munagala, Humail Patel, Pranav Sathe, Avneet Singh and Mangala NarasimhanAvailable online: 10 February 2025More LessIntroduction Pulmonary embolism (PE) associated with hemodynamic compromise, termed high-risk or massive acute PE (MAPE), is associated with increased morbidity and mortality. Despite advancements in procedural techniques and an increase in the availability of advanced therapies, the outcomes associated with high-risk PE remain poor. Here, we review the literature surrounding the use of Veno-arterial Extracorporeal Read More
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Pharmacogenomics and its Role in Cardiovascular Diseases: A Narrative Literature Review
Available online: 31 January 2025More LessPharmacogenomics has transformed the way we approach the treatment of the most common diseases worldwide, especially cardiovascular. In this article, we highlight the main categories of drugs involved in major cardiovascular diseases (CVD), related genetic variability and their effects on metabolism in each case of contrastive operability. This not only explains disparities in treatment outcomes but also unfolds customis Read More
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Evaluation of the Effect of Virgin Rice Bran Oil (VRBO) on Doxorubicin-Induced Cardiotoxicity in Wistar Rats
Authors: S. Prema, Rakesh Verma, Amritesh Nagarwal, Meenakshi Bharkatiya, Madhuri Baghel, Ladli Kishore, Pranay Wal and Amin GasmiAvailable online: 28 January 2025More LessObjective The usage of doxorubicin (DOX), an antineoplastic drug that is frequently used for the cure of cancer, is restricted to maximal doses due to its cardiac toxicity. Reactive oxygen species produced by DOX result in lipid peroxidation and organ failure, ultimately resulting in cardiomyopathy. Due to its high polyphenol content, virgin rice bran oil (VRBO) is a diet nutritional supplement with a strong antioxidant. Read More
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Safety and Efficacy of Transendocardial Stem Cells Therapy in Chronic Ischemic Heart Failure: A Systematic Review and Meta-analysis of Randomized Controlled Trials
Available online: 27 January 2025More LessIntroduction Chronic ischemic heart failure is a major global health issue despite advancements in therapy. Stem cell (SC) therapy has emerged as a potential treatment, but its effectiveness remains uncertain. This study aimed to systematically review and meta-analyze the current evidence on SC therapy's efficacy. Methods We conducted a comprehensive literature search in PubMed, Embase, and Cochrane databases up to Apr Read More
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Exploring the Involvement of New Members of the Interleukin Family in Cardiovascular Disease
Available online: 21 January 2025More LessCardiovascular diseases remain a significant reason for illness and death globally. Although certain interleukins have been extensively researched about cardiovascular disease (CVD), new findings have identified unique members of the interleukin family that could potentially play a role in cardiovascular well-being and ailments. This review discusses the current understanding of the role of these recently identified interleuki Read More
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A New Mechanism of Supraventricular Tachycardia: Gene Mutation
Authors: Jie Gao, Rong Luo and Xiaoping LiAvailable online: 20 January 2025More LessBackground Supraventricular tachycardia (SVT) is very common in daily clinical practice, especially in the emergency department, with rapid onset and urgent management. The review highlights the recent genetic predispositions and mechanisms in SVT. Methods Through analysis of epidemiology, familial clustering, and gene mutations of the relevant literature,the review elucidates the genetic properties and potentia Read More
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Unlocking Platelet Mechanisms through Multi-Omics Integration: A Brief Review
Available online: 13 January 2025More LessPlatelets, tiny cell fragments measuring 2-4 μm in diameter without a nucleus, play a crucial role in blood clotting and maintaining vascular integrity. Abnormalities in platelets, whether genetic or acquired, are linked to bleeding disorders, increased risk of blood clots, and cardiovascular diseases. Advanced proteomic techniques offer profound insights into the roles of platelets in hemostasis and their involvement in proce Read More
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The Intersection of Heart Failure and Iron Deficiency Anemia: Diagnostic and Therapeutic Approaches
Available online: 03 January 2025More LessIron deficiency anemia (IDA) is highly prevalent among individuals with heart failure (HF), impacting 40-70% of patients and serving as a significant prognostic indicator. Linked with oxidative metabolism and myocardial cell damage, IDA exacerbates HF symptoms, including reduced exercise capacity, diminished quality of life, and heightened cardiovascular morbidity. This review explores the diagnosis, treatment, clinical outc Read More
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Identifying Biomarkers for Atherosclerosis via Gene Expression and Biological Networking
Authors: Sangeeta Chhotaray and Soumya JalAvailable online: 03 January 2025More LessBackground Atherosclerosis is a chronic disease caused by the accumulation of lipids, inflammatory cells, and fibrous elements in arterial walls, leading to plaque formation and cardiovascular conditions like coronary artery disease, stroke, and peripheral arterial disease. Factors like hyperlipide mia, hypertension, smoking, and diabetes contribute to its development. Diagnosis relies on imaging and biomarkers, while Read More
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Successful Use of Proprotein Convertase Subtilisin/Kexin Type 9 Inhibitors in Hypertriglyceridemia-induced Acute Pancreatitis: A Case Report
Authors: Rundi Qi, Hailei Liu, Xin Li and Minglong ChenAvailable online: 03 January 2025More LessBackground Managing hypertriglyceridemia-induced acute pancreatitis (HTG-AP) can be challenging, particularly due to the need for rapid triglyceride reduction to below 500mg/dL (5.645mmol/L). Case Report This is a case describing a 39-year-old female patient who presented to the Emergency Department with acute abdominal pain resulting from severe HTG-AP. However, under conventional therapy with oral lipid-lo Read More
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Unlocking the Potential: Phytoestrogens and Cardiovascular Health
Authors: Arvind Gulati, Himanshi Banker, Alina Amin Muhammad, FNU Anamika and Rohit JainAvailable online: 02 January 2025More LessPhytoestrogens are plant-derived compounds resembling human estrogen and have recently gained attention due to their potential role in improving cardiovascular health. These compounds exert their effects through various mechanisms, including interactions with estrogen receptors, growth factor receptors, inflammatory mediators, thrombogenic reactions, and apoptotic pathways. This results in cardioprotective effe Read More
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Serum Cortisol and Cardiovascular Disease Risk-A Potential Biomarker
Authors: Wei Jet Oo, Chooi Ling Lim, Mun Hon Goh and Rhun Yian KohAvailable online: 01 January 2025More LessCardiovascular Disease [CVD], the leading cause of death globally, poses a significant burden on the healthcare sector. Its association with stress and Cushing’s Syndrome has driven cortisol, the ‘stress hormone,’ to be a potential candidate in determining CVD risk. Cortisol synthesis and release through the hypothalamic-pituitary-adrenal [HPA] axis are regulated by several hormones and receptors involved in the patholo Read More
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Atrial Fibrillation Ablation in Heart Failure and Preserved Ejection Fraction: An Observational Study of Risk Factors for Heart Failure Hospitalization
Authors: Rundi Qi, Hailei Liu, Yue Zhu, Nan Wu, Kexin Wang, Xiangwei Ding, Zhoushan Gu, Mingfang Li, Hongwu Chen, Weizhu Ju, Xin Li and Minglong ChenAvailable online: 09 December 2024More LessIntroduction Long-term heart failure hospitalization (HFH) after radiofrequency catheter ablation (RFCA) in atrial fibrillation (AF) patients with heart failure and preserved ejection fraction (HFpEF) and its risk factors remain to be investigated. Methods AF patients with HFpEF who underwent RFCA from January, 2014 to December, 2018 from three centers were retrospectively included. Patients were assigned to the training and tes Read More
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