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Volume 21, Issue 2, 2025
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Importance of Zinc Homeostasis for Normal Cardiac Rhythm
Current arrhythmia therapies such as ion channel blockers, catheter ablation, or implantable cardioverter defibrillators have limitations and side effects, and given the proarrhythmic risk associated with conventional, ion channel-targeted anti-arrhythmic drug therapies, a new approach to arrhythmias may be warranted. Measuring and adjusting the level of specific ions that impact heart rhythm can be a simple and low-co Read More
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Elevated Perspectives: Unraveling Cardiovascular Dynamics in High-Altitude Realms
High-altitude regions pose distinctive challenges for cardiovascular health because of decreased oxygen levels, reduced barometric pressure, and colder temperatures. Approximately 82 million people live above 2400 meters, while over 100 million people visit these heights annually. Individuals ascending rapidly or those with pre-existing cardiovascular conditions are particularly vulnerable to altitude-related illnesses, including A Read More
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Comprehensive Review of Coronary Artery Anatomy Relevant to Cardiac Surgery
Authors: Emeka B. Kesieme, Benjamin Omoregbee, Dumbor L. Ngaage and Mark H.D. DantonIn order to perform safe cardiac surgery, a knowledge of applied coronary artery anatomy and its variants is essential for cardiac surgeons. In normal individuals, the right and the left coronary arteries arise from the corresponding sinuses of Valsalva within the aortic root. From the cardiac surgical perspective, the coronary artery is divided into the left main coronary artery, its branches (the left anterior descending artery a Read More
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Unveiling the Complexities: Exploring Mechanisms of Anthracycline-induced Cardiotoxicity
Authors: Rohit Tayal, Ashi Mannan, Shareen Singh, Sonia Dhiman and Thakur Gurjeet SinghThe coexistence of cancer and heart disease, both prominent causes of illness and death, is further exacerbated by the detrimental impact of chemotherapy. Anthracycline-induced cardiotoxicity is an unfortunate side effect of highly effective therapy in treating different types of cancer; it presents a significant challenge for both clinicians and patients due to the considerable risk of cardiotoxicity. Despite significant progress Read More
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Heart Rate Variability and Heart Failure with Reduced Ejection Fraction: A Systematic Review of Literature
Authors: Michiaki Nagai, Hallum Ewbank, Yukiko Nakano, Benjamin J. Scherlag, Sunny S. Po and Tarun W. DasariIntroductionAutonomic impairment is a hallmark of heart failure with reduced ejection fraction (HFrEF). While there have been studies on general values for each index of heart rate variability (HRV) analysis in HFrEF, a systematic review comprehensively examining representative values in HFrEF is lacking.MethodsWe searched PubMed, Embase, and Cochrane databases to extract studies reporting representative values of H Read More
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Diabetic Cardiomyopathy: An Update on Emerging Pathological Mechanisms
Diabetic Cardiomyopathy (DCM) is a notable consequence of diabetes mellitus, distinguished by cardiac dysfunction that occurs separately from coronary artery disease or hypertension. A recent study has revealed an intricate interaction of pathogenic processes that contribute to DCM. Important aspects involve the dysregulation of glucose metabolism, resulting in heightened oxidative stress and impaired mitochondrial Read More
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Targeting Wnt Pathways with Small Molecules as New Approach in Cardiovascular Disease
The increasing incidences of morbidity and mortality associated with cardiovascular diseases represent significant difficulties for clinical treatment and have a major impact on patient health. Wnt signaling pathways are highly conserved and are well known for their regulatory roles in embryonic development, tissue regeneration, and adult tissue homeostasis. Wnt signaling is classified into two distinct pathways: canonical Wnt/β-c Read More
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Volumes & issues
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Volume 21 (2025)
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Volume 20 (2024)
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Volume 19 (2023)
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Volume 18 (2022)
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Volume 17 (2021)
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Volume 16 (2020)
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Volume 15 (2019)
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Volume 14 (2018)
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Volume 13 (2017)
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Volume 12 (2016)
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Volume 11 (2015)
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Volume 10 (2014)
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Volume 9 (2013)
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Volume 8 (2012)
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Volume 7 (2011)
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Volume 6 (2010)
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Volume 5 (2009)
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Volume 4 (2008)
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Volume 3 (2007)
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Volume 2 (2006)
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Volume 1 (2005)
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