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Volume 21, Issue 4
  • ISSN: 1573-403X
  • E-ISSN: 1875-6557

Abstract

Introduction

Pulmonary embolism (PE) associated with hemodynamic compromise, termed high-risk or massive acute PE (MAPE), is associated with increased morbidity and mortality. Despite advancements in procedural techniques and an increase in the availability of advanced therapies, the outcomes associated with high-risk PE remain poor. Here, we review the literature surrounding the use of Veno-arterial Extracorporeal Membrane Oxygenation (VA-ECMO), primarily as a bridging therapy, in patients presenting with high-risk pulmonary embolism.

Methods

We conducted a systematic review and meta-analysis utilizing PubMed/MEDLINE from database inception until March 2024. The terms “high-risk PE”, “massive PE” and “MAPE” were paired with “VA-ECMO”, “bridge therapy” and “solo therapy” along with related terms to find and analyze relevant studies. The primary outcome assessed was in-hospital mortality.

Results

Most comparative studies involved assessing VA-ECMO's utility as solo therapy as a bridge to advanced therapy. Out of the data involving VA-ECMO as solo therapy, most showed definite survival benefit in subset of populations with VA-ECMO's role being varied by age and cardiac arrest presence. A portion of studies were notable for finding no difference in outcomes; however no major retrospective determined negative effect of VA-ECMO. In head-to-head studies as a bridge, studies from multiple centers highlighted VA-ECMO's role in stabilizing and improving survival in massive PE prior to systemic or catheter directed thrombolysis. Follow-up studies were limited, however one retrospective showed 30-day mortality of 31% and the 1-year mortality of 54% post PERT call. Follow-up echocardiograms performed on survivors between 30-365 days from Pulmonary Embolism Response Team (PERT) activation interestingly all had normal Right Ventricular (RV) size and function with mild to no tricuspid regurgitation.

Conclusion

Most major literature supports the use of VA-ECMO as either solo therapy or a bridge to advanced therapy in MAPE with additional shock or cardiac arrest. However, further studies are needed to develop society guidelines for regular initiation in cases of MAPE.

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2025-06-27

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References

  1. QuezadaC.A. BikdeliB. BarriosD. BarberoE. ChiluizaD. MurielA. CasazzaF. MonrealM. YusenR.D. JiménezD. Meta-analysis of prevalence and short-term prognosis of hemodynamically unstable patients with symptomatic acute pulmonary embolism.Am. J. Cardiol.2019123468468910.1016/j.amjcard.2018.11.00930528278
     [Google Scholar]
  2. KahnS.R. de WitK. Pulmonary embolism.N. Engl. J. Med.20223871455710.1056/NEJMcp211648935793208
     [Google Scholar]
  3. de WitK. D’ArsignyC.L. Risk stratification of acute pulmonary embolism.J. Thromb. Haemost.202321113016302310.1016/j.jtha.2023.05.00337187357
     [Google Scholar]
  4. KucherN. RossiE. De RosaM. GoldhaberS.Z. Massive pulmonary embolism.Circulation2006113457758210.1161/CIRCULATIONAHA.105.59259216432055
     [Google Scholar]
  5. SecemskyE. ChangY. JainC.C. BeckmanJ.A. GiriJ. JaffM.R. RosenfieldK. RosovskyR. KabrhelC. WeinbergI. Contemporary management and outcomes of patients with massive and submassive pulmonary embolism.Am. J. Med.20181311215061514.e010.1016/j.amjmed.2018.07.03530102908
     [Google Scholar]
  6. YamamotoT. Management of patients with high-risk pulmonary embolism: A narrative review.J. Intensive Care2018611610.1186/s40560‑018‑0286‑829511564
     [Google Scholar]
  7. SaricM. ArmourA.C. ArnaoutM.S. ChaudhryF.A. GrimmR.A. KronzonI. LandeckB.F. MagantiK. MichelenaH.I. TolstrupK. Guidelines for the use of echocardiography in the evaluation of a cardiac source of embolism.J. Am. Soc. Echocardiogr.201629114210.1016/j.echo.2015.09.01126765302
     [Google Scholar]
  8. GoldhaberS.Z. ElliottC.G. Acute pulmonary embolism: Part i: Epidemiology, pathophysiology, and diagnosis.Circulation2003108222726272910.1161/01.CIR.0000097829.89204.0C14656907
     [Google Scholar]
  9. SantolicandroA. PredilettoR. FornaiE. FormichiB. BegliominiE. Giannella-NetoA. GiuntiniC. Mechanisms of hypoxemia and hypocapnia in pulmonary embolism.Am. J. Respir. Crit. Care Med.1995152133634710.1164/ajrccm.152.1.75998437599843
     [Google Scholar]
  10. KaplovitchE. ShawJ.R. DouketisJ. Thrombolysis in pulmonary embolism.Crit. Care Clin.202036346548010.1016/j.ccc.2020.02.00432473692
     [Google Scholar]
  11. OrtelT.L. NeumannI. AgenoW. BeythR. ClarkN.P. CukerA. HuttenB.A. JaffM.R. ManjaV. SchulmanS. ThurstonC. VedanthamS. VerhammeP. WittD.M. D FlorezI. IzcovichA. NieuwlaatR. RossS. J SchünemannH. WierciochW. ZhangY. ZhangY. American society of hematology 2020 guidelines for management of venous thromboembolism: Treatment of deep vein thrombosis and pulmonary embolism.Blood Adv.20204194693473810.1182/bloodadvances.202000183033007077
     [Google Scholar]
  12. GuyattG.H. AklE.A. CrowtherM. GuttermanD.D. SchuünemannH.J. American college of chest physicians antithrombotic therapy and prevention of thrombosis panel. Executive summary.Chest201214127S47S10.1378/chest.1412S322315257
     [Google Scholar]
  13. DudzinskiD.M. GiriJ. RosenfieldK. Interventional treatment of pulmonary embolism.Circ. Cardiovasc. Interv.2017102e00434510.1161/CIRCINTERVENTIONS.116.00434528213377
     [Google Scholar]
  14. GoldhaberS.Z. ComeP.C. LeeR.T. BraunwaldE. ParkerJ.A. HaireW.D. FeldsteinM.L. MillerM. ToltzisR. SmithJ.L. Taveira de SilvaA.M. MogtaderA. McDonoughT.J. Alteplase versus heparin in acute pulmonary embolism: Randomised trial assessing right-ventricular function and pulmonary perfusion.Lancet1993341884450751110.1016/0140‑6736(93)90274‑K8094768
     [Google Scholar]
  15. Dalla-VoltaS. PallaA. SantolicandroA. GiuntiniC. PengoV. VisioliO. ZonzinP. ZanuttiniD. BarbaresiF. AgnelliG. MorpurgoM. MariniM.G. VisaniL. Paims 2: Alteplase combined with heparin versus heparin in the treatment of acute pulmonary embolism. plasminogen activator italian multicenter study 2.J. Am. Coll. Cardiol.199220352052610.1016/0735‑1097(92)90002‑51512328
     [Google Scholar]
  16. MartiC. JohnG. KonstantinidesS. CombescureC. SanchezO. LankeitM. MeyerG. PerrierA. Systemic thrombolytic therapy for acute pulmonary embolism: A systematic review and meta-analysis.Eur. Heart J.2015361060561410.1093/eurheartj/ehu21824917641
     [Google Scholar]
  17. GötzingerF. LauderL. SharpA.S.P. LangI.M. RosenkranzS. KonstantinidesS. EdelmanE.R. BöhmM. JaberW. MahfoudF. Interventional therapies for pulmonary embolism.Nat. Rev. Cardiol.2023201067068410.1038/s41569‑023‑00876‑037173409
     [Google Scholar]
  18. KuoW.T. BanerjeeA. KimP.S. DeMarcoF.J.Jr LevyJ.R. FacchiniF.R. UnverK. BertiniM.J. SistaA.K. HallM.J. RosenbergJ.K. De GregorioM.A. Pulmonary embolism response to fragmentation, embolectomy, and catheter thrombolysis (perfect).Chest2015148366767310.1378/chest.15‑011925856269
     [Google Scholar]
  19. TapsonV.F. SterlingK. JonesN. ElderM. TripathyU. BrowerJ. MaholicR.L. RossC.B. NatarajanK. FongP. GreensponL. TamaddonH. PirachaA.R. EngelhardtT. KatopodisJ. MarquesV. SharpA.S.P. PiazzaG. GoldhaberS.Z. A randomized trial of the optimum duration of acoustic pulse thrombolysis procedure in acute intermediate-risk pulmonary embolism.JACC Cardiovasc. Interv.201811141401141010.1016/j.jcin.2018.04.00830025734
     [Google Scholar]
  20. PiazzaG. HohlfelderB. JaffM.R. OurielK. EngelhardtT.C. SterlingK.M. JonesN.J. GurleyJ.C. BhathejaR. KennedyR.J. GoswamiN. NatarajanK. RundbackJ. SadiqI.R. LiuS.K. BhallaN. RajaM.L. WeinstockB.S. CynamonJ. ElmasriF.F. GarciaM.J. KumarM. AyerdiJ. SoukasP. KuoW. LiuP.Y. GoldhaberS.Z. A prospective, single-arm, multicenter trial of ultrasound-facilitated, catheter-directed, low-dose fibrinolysis for acute massive and submassive pulmonary embolism.JACC Cardiovasc. Interv.20158101382139210.1016/j.jcin.2015.04.02026315743
     [Google Scholar]
  21. FukudaI. DaitokuK. Surgical embolectomy for acute pulmonary thromboembolism.Ann. Vasc. Dis.201710210711410.3400/avd.ra.17‑0003829034035
     [Google Scholar]
  22. GoldbergJ.B. GiriJ. KobayashiT. RuelM. MittnachtA.J.C. Rivera-LebronB. DeAndaA.Jr MoriartyJ.M. MacGillivrayT.E. Surgical management and mechanical circulatory support in high-risk pulmonary embolisms: Historical context, current status, and future directions: A scientific statement from the american heart association.Circulation20231479e628e64710.1161/CIR.000000000000111736688837
     [Google Scholar]
  23. KeelingW.B. SundtT. LeaccheM. OkitaY. BinongoJ. LasajanakY. AklogL. LattoufO.M. Outcomes after surgical pulmonary embolectomy for acute pulmonary embolus: A multi-institutional study.Ann. Thorac. Surg.201610251498150210.1016/j.athoracsur.2016.05.00427373187
     [Google Scholar]
  24. LeeT. ItagakiS. ChiangY.P. EgorovaN.N. AdamsD.H. ChikweJ. Survival and recurrence after acute pulmonary embolism treated with pulmonary embolectomy or thrombolysis in new york state, 1999 to 2013.J. Thorac. Cardiovasc. Surg.2018155310841090.e1210.1016/j.jtcvs.2017.07.07428942971
     [Google Scholar]
  25. YuriditskyE. BakkerJ. AlviarC.L. BangaloreS. HorowitzJ.M. Venoarterial extracorporeal membrane oxygenation in high-risk pulmonary embolism: A narrative review.J. Crit. Care20248415489110.1016/j.jcrc.2024.15489139079203
     [Google Scholar]
  26. CooleyD.A. BeallA.C.Jr AlexanderJ.K. Acute massive pulmonary embolism. successful surgical treatment using temporary cardiopulmonary bypass.JAMA1961177528328610.1001/jama.1961.0304031000100113695276
     [Google Scholar]
  27. PasrijaC. KronfliA. GeorgeP. RaithelM. BoulosF. HerrD.L. GammieJ.S. PhamS.M. GriffithB.P. KonZ.N. Utilization of veno-arterial extracorporeal membrane oxygenation for massive pulmonary embolism.Ann. Thorac. Surg.2018105249850410.1016/j.athoracsur.2017.08.03329174781
     [Google Scholar]
  28. BaldettiL. BeneduceA. CianfanelliL. FalasconiG. PannoneL. MoroniF. VenutiA. SacchiS. GramegnaM. PazzaneseV. CalvoF. GalloneG. PagnesiM. CappellettiA.M. Use of extracorporeal membrane oxygenation in high‐risk acute pulmonary embolism: A systematic review and meta‐analysis.Artif. Organs202145656957610.1111/aor.1387633277695
     [Google Scholar]
  29. MeneveauN. GuillonB. PlanquetteB. PitonG. KimmounA. Gaide-ChevronnayL. AissaouiN. NeuschwanderA. ZogheibE. DupontH. Pili-FlouryS. EcarnotF. SchieleF. DeyeN. de ProstN. FavoryR. GirardP. CristinarM. FerréA. MeyerG. CapellierG. SanchezO. Outcomes after extracorporeal membrane oxygenation for the treatment of high-risk pulmonary embolism: A multicentre series of 52 cases.Eur. Heart J.201839474196420410.1093/eurheartj/ehy46430137303
     [Google Scholar]
  30. FarmakisI.T. SagoschenI. BarcoS. KellerK. ValerioL. WildJ. GiannakoulasG. PiazzaG. KonstantinidesS.V. HobohmL. Extracorporeal membrane oxygenation and reperfusion strategies in high-risk pulmonary embolism hospitalizations.Crit. Care Med.20245210e512e52110.1097/CCM.000000000000636138904439
     [Google Scholar]
  31. CorsiF. LebretonG. BréchotN. HekimianG. NieszkowskaA. TrouilletJ.L. LuytC.E. LeprinceP. ChastreJ. CombesA. SchmidtM. Life-threatening massive pulmonary embolism rescued by venoarterial-extracorporeal membrane oxygenation.Crit. Care20172117610.1186/s13054‑017‑1655‑828347320
     [Google Scholar]
  32. KonstantinidesS.V. MeyerG. BecattiniC. BuenoH. GeersingG.J. HarjolaV.P. HuismanM.V. HumbertM. JenningsC.S. JiménezD. KucherN. LangI.M. LankeitM. LorussoR. MazzolaiL. MeneveauN. Ní ÁinleF. PrandoniP. PruszczykP. RighiniM. TorbickiA. Van BelleE. ZamoranoJ.L. GaliéN. GibbsJ.S.R. AboyansV. AgenoW. AgewallS. AlmeidaA.G. AndreottiF. BarbatoE. BauersachsJ. BaumbachA. BeyguiF. CarlsenJ. De CarloM. DelcroixM. DelgadoV. SubiasP.E. FitzsimonsD. GaineS. GoldhaberS.Z. GopalanD. HabibG. HalvorsenS. JenkinsD. KatusH.A. KjellströmB. LainscakM. LancellottiP. LeeG. Le GalG. MessasE. MoraisJ. PetersenS.E. PetronioA.S. PiepoliM.F. PriceS. RoffiM. SalviA. SanchezO. ShlyakhtoE. SimpsonI.A. StorteckyS. ThielmannM. NoordegraafA.V. BecattiniC. BuenoH. GeersingG-J. HarjolaV-P. HuismanM.V. HumbertM. JenningsC.S. JiménezD. KucherN. LangI.M. LankeitM. LorussoR. MazzolaiL. MeneveauN. Ní ÁinleF. PrandoniP. PruszczykP. RighiniM. TorbickiA. VanBelleE. LuisZamoranoJ. WindeckerS. AboyansV. BaigentC. ColletJ-P. DeanV. DelgadoV. FitzsimonsD. GaleC.P. GrobbeeD. HalvorsenS. HindricksG. IungB. JüniP. KatusH.A. LandmesserU. LeclercqC. LettinoM. LewisB.S. MerkelyB. MuellerC. PetersenS.E. Sonia PetronioA. RichterD.J. RoffiM. ShlyakhtoE. SimpsonI.A. Sousa-UvaM. TouyzR.M. HammoudiN. HayrapetyanH. MascherbauerJ. IbrahimovF. PolonetskyO. LancellottiP. TokmakovaM. SkoricB. MichaloliakosI. HutyraM. MellemkjaerS. MostafaM. ReinmetsJ. JääskeläinenP. AngoulvantD. BauersachsJ. GiannakoulasG. ZimaE. VizzaC.D. SugraliyevA. BytyçiI. MacaA. EreminieneE. HuijnenS. XuerebR. DiaconuN. BulatovicN. AsfalouI. BosevskiM. HalvorsenS. SobkowiczB. FerreiraD. PetrisA.O. MoiseevaO. ZavattaM. ObradovicS. ŠimkovaI. RadselP. IbanezB. WikströmG. AujeskyD. KaymazC. ParkhomenkoA. Pepke-ZabaJ. 2019 esc guidelines for the diagnosis and management of acute pulmonary embolism developed in collaboration with the European Respiratory Society (ERS).Eur. Heart J.202041454360310.1093/eurheartj/ehz40531504429
     [Google Scholar]
  33. PanchalA.R. BartosJ.A. CabañasJ.G. DonninoM.W. DrennanI.R. HirschK.G. KudenchukP.J. KurzM.C. LavonasE.J. MorleyP.T. O’NeilB.J. PeberdyM.A. RittenbergerJ.C. RodriguezA.J. SawyerK.N. BergK.M. ArafehJ. BenoitJ.L. ChaseM. FernandezA. de PaivaE.F. FischbergB.L. FloresG.E. FrommP. GazmuriR. GibsonB.C. HoadleyT. HsuC.H. IssaM. KesslerA. LinkM.S. MagidD.J. MarrillK. NicholsonT. OrnatoJ.P. PachecoG. ParrM. PawarR. JaxtonJ. PermanS.M. PribbleJ. RobinettD. RolstonD. SassonC. SatyapriyaS.V. SharkeyT. SoarJ. TormanD. Von SchweinitzB. UzenduA. ZelopC.M. MagidD.J. Part 3: Adult basic and advanced life support: 2020 American Heart Association Guidelines for cardiopulmonary resuscitation and emergency cardiovascular care.Circulation202014216_suppl_2S366S46810.1161/CIR.000000000000091633081529
     [Google Scholar]
  34. SeatonA. HodgsonL.E. Creagh-BrownB. PakavakisA. WyncollD.L.A. Doyle JFJ.F. The use of veno-venous extracorporeal membrane oxygenation following thrombolysis for massive pulmonary embolism.J. Intensive Care Soc.201718434234710.1177/175114371770215529123568
     [Google Scholar]
  35. KmiecL. PhilippA. FloerchingerB. LubnowM. UnterbuchnerC. CreutzenbergM. LunzD. MuellerT. SchmidC. CamboniD. Extracorporeal membrane oxygenation for massive pulmonary embolism as bridge to therapy.ASAIO J.202066214615210.1097/MAT.000000000000095330720492
     [Google Scholar]
  36. RosovskyR. ZhaoK. SistaA. Rivera-LebronB. KabrhelC. Pulmonary embolism response teams: Purpose, evidence for efficacy, and future research directions.Res. Pract. Thromb. Haemost.20193331533010.1002/rth2.1221631294318
     [Google Scholar]
  37. DudzinskiD.M. PiazzaG. Multidisciplinary pulmonary embolism response teams.Circulation201613319810310.1161/CIRCULATIONAHA.115.01508626719388
     [Google Scholar]
  38. KabrhelC. RosovskyR. ChannickR. JaffM.R. WeinbergI. SundtT. DudzinskiD.M. Rodriguez-LopezJ. ParryB.A. HarshbargerS. ChangY. RosenfieldK. A multidisciplinary pulmonary embolism response team.Chest2016150238439310.1016/j.chest.2016.03.01127006156
     [Google Scholar]
  39. MartinK.A. MolsberryR. CutticaM.J. DesaiK.R. SchimmelD.R. KhanS.S. Time trends in pulmonary embolism mortality rates in the united states, 1999 to 2018.J. Am. Heart Assoc.2020917e01678410.1161/JAHA.120.01678432809909
     [Google Scholar]
  40. ElbadawiA. MentiasA. ElgendyI.Y. MohamedA.H. SyedM.H.Z. OgunbayoG.O. OlorunfemiO. GosevI. PrasadS. CameronS.J. National trends and outcomes for extra-corporeal membrane oxygenation use in high-risk pulmonary embolism.Vasc. Med.201924323023310.1177/1358863X1882465030834824
     [Google Scholar]
  41. BhallaA. AttaranR. Mechanical circulatory support to treat pulmonary embolism: Venoarterial extracorporeal membrane oxygenation and right ventricular assist devices.Tex. Heart Inst. J.202047320220610.14503/THIJ‑19‑702532997787
     [Google Scholar]
  42. KasoE.R. PanJ.A. SalernoM. KadlA. AldridgeC. HaskalZ.J. KennedyJ.L.W. MazimbaS. MihalekA.D. TemanN.R. GiriJ. AronowH.D. SharmaA.M. Venoarterial extracorporeal membrane oxygenation for acute massive pulmonary embolism: A meta-analysis and call to action.J. Cardiovasc. Transl. Res.202215225826710.1007/s12265‑021‑10158‑034282541
     [Google Scholar]
  43. TsaiH.Y. WangY.T. LeeW.C. YenH.T. LoC.M. WuC.C. HuangK.R. ChenY.C. SheuJ.J. ChenY.Y. Efficacy and safety of veno-arterial extracorporeal membrane oxygenation in the treatment of high-risk pulmonary embolism: A retrospective cohort study.Front. Cardiovasc. Med.2022979948810.3389/fcvm.2022.79948835310966
     [Google Scholar]
  44. KaramiM. MandigersL. MirandaD.D.R. RietdijkW.J.R. BinnekadeJ.M. KnijnD.C.M. LagrandW.K. den UilC.A. HenriquesJ.P.S. VlaarA.P.J. Survival of patients with acute pulmonary embolism treated with venoarterial extracorporeal membrane oxygenation: A systematic review and meta-analysis.J. Crit. Care20216424525410.1016/j.jcrc.2021.03.00634049258
     [Google Scholar]
  45. ScottJ.H. GordonM. VenderR. PettigrewS. DesaiP. MarchettiN. MamaryA.J. PanaroJ. CohenG. BashirR. LakhterV. RothS. ZhaoH. ToyodaY. CrinerG. MooresL. RaliP. Venoarterial extracorporeal membrane oxygenation in massive pulmonary embolism-related cardiac arrest: A systematic review.Crit. Care Med.202149576076910.1097/CCM.000000000000482833590996
     [Google Scholar]
  46. HobohmL. SagoschenI. HabertheuerA. BarcoS. ValerioL. WildJ. SchmidtF.P. GoriT. MünzelT. KonstantinidesS. KellerK. Clinical use and outcome of extracorporeal membrane oxygenation in patients with pulmonary embolism.Resuscitation202217028529210.1016/j.resuscitation.2021.10.00734653550
     [Google Scholar]
  47. OhY.N. OhD.K. KohY. LimC.M. HuhJ.W. LeeJ.S. JungS.H. KangP.J. HongS.B. Use of extracorporeal membrane oxygenation in patients with acute high-risk pulmonary embolism: A case series with literature review.Acute Crit. Care201934214815410.4266/acc.2019.0050031723920
     [Google Scholar]
  48. GulianiS. Das GuptaJ. OsofskyR. KraaiE.P. MitchellJ.A. DettmerT.S. WrayT.C. TawilI. RanaM.A. MarinaroJ. Venoarterial extracorporeal membrane oxygenation is an effective management strategy for massive pulmonary embolism patients.J. Vasc. Surg. Venous Lymphat. Disord.20219230731410.1016/j.jvsv.2020.04.03332505687
     [Google Scholar]
  49. GiraudR. LaurencetM. AssoulineB. De CharrièreA. BanfiC. BendjelidK. Can va-ecmo be used as an adequate treatment in massive pulmonary embolism?J. Clin. Med.20211015337610.3390/jcm1015337634362159
     [Google Scholar]
  50. PrasadN.K. BoyajianG. TranD. ShahA. JonesK.M. MadathilR.J. DeatrickK.B. Cires-DrouetR. KaczorowskiD.J. Veno-arterial extracorporeal membrane oxygenation for pulmonary embolism after systemic thrombolysis.Semin. Thorac. Cardiovasc. Surg.202234254955710.1053/j.semtcvs.2021.04.00433974966
     [Google Scholar]
  51. Al-BawardyR. RosenfieldK. BorgesJ. YoungM.N. AlbaghdadiM. RosovskyR. KabrhelC. Extracorporeal membrane oxygenation in acute massive pulmonary embolism: A case series and review of the literature.Perfusion2019341222810.1177/026765911878683030009670
     [Google Scholar]
  52. GeorgeB. ParazinoM. OmarH.R. DavisG. GuglinM. GurleyJ. SmythS. A retrospective comparison of survivors and non-survivors of massive pulmonary embolism receiving veno-arterial extracorporeal membrane oxygenation support.Resuscitation20181221510.1016/j.resuscitation.2017.11.03429128608
     [Google Scholar]
  53. AssoulineB. Assouline-ReinmannM. GiraudR. LevyD. SauraO. BendjelidK. CombesA. SchmidtM. Management of high-risk pulmonary embolism: What is the place of extracorporeal membrane oxygenation?J. Clin. Med.20221116473410.3390/jcm1116473436012973
     [Google Scholar]
  54. IusF. HoeperM.M. FegbeutelC. KühnC. OlssonK. KoigeldiyevN. TudoracheI. WarneckeG. OptenhöfelJ. PuntigamJ.O. SchäferA. MeyerB.C. HinrichsJ.B. BauersachsJ. HaverichA. CebotariS. Extracorporeal membrane oxygenation and surgical embolectomy for high-risk pulmonary embolism.Eur. Respir. J.2019534180177310.1183/13993003.01773‑201830728206
     [Google Scholar]
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The use of Veno-arterial Extracorporeal Membrane Oxygenation (VA-ECMO) for Acute High Risk Pulmonary Embolism: A Systematic Review
Curr. Cardiol. Rev. 21, E1573403X339627 (2025); https://doi.org/10.2174/011573403X339627241224085451
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  • Article Type:     Review Article
Keyword(s): bridge therapy; hypoxia; Pulmonary embolism; solo therapy; thrombolysis; veno-arterial extracorporeal membrane oxygenation

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