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Volume 21, Issue 3
  • ISSN: 1573-403X
  • E-ISSN: 1875-6557

Abstract

Introduction

Managing hypertriglyceridemia-induced acute pancreatitis (HTG-AP) can be challenging, particularly due to the need for rapid triglyceride reduction to below 500mg/dL (5.645 mmol/L).

Case Report

This is a case describing a 39-year-old female patient who presented to the Emergency Department with acute abdominal pain resulting from severe HTG-AP. However, under conventional therapy with oral lipid-lowering drugs, the triglyceride levels remained uncontrolled. Oral moderate-intensity statins could not only reduce low-density lipoprotein cholesterol (LDLc) by 25%-50%. However, increasing the dose could not further reduce blood lipids while increasing the risk of liver damage. After the administration of proprotein convertase subtilisin/kexin type 9 inhibitor (PCSK9i), the triglyceride levels were well controlled with no additional side effects, and the symptoms of the patients were completely relieved.

Conclusion

In cases of unsatisfactory lipid control under conventional therapy, PCSK9i may offer a viable option for managing HTG-AP.

© 2025 Bentham Science Publishers
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2025-01-03
2025-05-23

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/content/journals/ccr/10.2174/011573403X343784241115055037
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Successful use of Proprotein Convertase Subtilisin/Kexin Type 9 Inhibitors in Hypertriglyceridemia-induced Acute Pancreatitis: A Case Report
Curr. Cardiol. Rev. 21, E1573403X343784 (2025); https://doi.org/10.2174/011573403X343784241115055037
/content/journals/ccr/10.2174/011573403X343784241115055037
/content/journals/ccr/10.2174/011573403X343784241115055037
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  • Article Type:     Case Report
Keyword(s): acute abdominal pain; acute pancreatitis; Hypertriglyceridemia; low-density lipoprotein cholesterol; proprotein convertase subtilisin/kexin type 9 inhibitor; triglyceride reduction

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