Current Bioactive Compounds - Online First

Background Bioactive compounds were isolated, characterized, but their efficacy, potency and mechanism of action to treat/prevent several diseases yet to defined. The present review provides the insight on the activity of nature derived bioactive compounds therapeutic potential against communicable and non-communicable disease by using in silico approaches such as structure-based virtual screening, ligand-based virt Read More

The impact of naturally occurring flavonoids on human health and illnesses is crucial, as they are closely linked to dietary components and human health. Flavonoids may be able to shield people against disease in both in vitro and in vivo research settings. The flavonoid chrysin has demonstrated several intriguing pharmacological properties, including immune modulation, anti-cancer, anti-diabetic, antidepressant, a Read More

Background Tetrazole-based compounds are of significant interest due to their potential pharmacological applications. The current study focuses on the synthesis and analysis of such a compound. Objective This research aims to synthesize the title compound N-(3-methyl-1-phenyl-2-(1H-tetrazol-1-yl) butyl) acetamide, analyze its crystal structure, perform computational studies, and evaluate its potential pharmacological activities Read More

Withania somnifera (L.) Dunal (W. somnifera) is an herb commonly known by its English name Winter Cherry, and Ashwagandha in Hindi. It has been used as a traditional Rasayana herb for a long time. It is a rich reservoir of bioactive compounds known as withanolides, namely, withaferin-A and withanolide-D. Its current research covers many aspects of human health, which include anti-stress, anti-tumor, 9immuno-modulato Read More

Bakuchiol, a meroterpene natural product found in various plants, exhibits diverse biological activities, notably anticancer properties. Researchers have synthesized numerous analogs targeting different positions, such as alcoholic OH, ethenyl, and isopropylidene groups within bakuchiol, aiming to enlighten potent therapeutic agents with enhanced pharmaceutical characteristics. The review aims to focus on the extensive potenti Read More

Aim Present study deals to access the antidepressant activity of Etlingera elatior leaves extract in rodent. Background Etlingera elatior is a species of herbaceous perennial plant in the family Zingiberaceae; native to Indonesia, Thailand, Malaysia and New Guinea. Depression is one of the most common mental disorders affecting humans, pathological basis of which is not fully understood. The current antidepressant drugs have Read More

Background Colorectal cancer (CRC) is the third most common cause of cancer-related deaths worldwide. To develop more effective anti-CRC drugs, this research evaluated the impact of synthesized liposomal daunorubicin on HTC116 colon cancer cell line. Methods Liposomal daunorubicin (LDNR) was synthesized by the thin layer hydration method and size was determined by dynamic light diffraction (DLS). MTT assay was u Read More