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Current Bioactive Compounds - Online First

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3 results

    • Biologically Active Components of Seven Species and their Osteogenic and Hematopoietic Activity in Experimental Osteomyelitis

      https://doi.org/10.2174/0115734072357086250303055104
      Available online: 12 March 2025
      Background

      Plant extracts containing polysaccharides, flavonoids, and chelated calcium compounds are effective for the complex therapy of osteomyelitis. In this study, the content of target components in the extracts of seven DC species was studied, and their osteogenic and hematopoietic activities in model osteomyelitis were investigated.

      Methods

      The content of chelidonic acid by high-performance liquid chromatography, flavonoids by spectrophotometric method, polysaccharides by gravimetric method, and calcium by automatic analyzer in extracts was determined. Biological experiments were carried out on rats using the model of experimental osteomyelitis.

      Results

      The largest amount of calcium (3-4 mmol/l) in , , and , chelidonic acid (122 mg/g) in , and flavonoids (63-74 mg/g) and polysaccharides (218-251 mg/g) in and extracts was found. In the model osteomyelitis, the studied extracts stimulated bone marrow hematopoiesis, and the total number of bone marrow cells increased after treatment with extract by 50% and with and extracts by 28% compared to the control. After treatment with extracts, the intensity of inflammation in the bone tissue decreased, and regenerative processes intensified. Moreover, the area of mature bone tissue increased by 72% after treatment with and extracts, indicating the successful completion of the bone regeneration process.

      Conclusion

      Plants of the genus (S. DC, S. (Poir.) DC, S. Ledeb., S. Adams., and S. (L.) DC) showed osteogenic and hematopoietic efficacy in the osteomyelitis model of rats. Extracts and biologically active components of these plants can expand the arsenal of sources for the complex therapy of osteomyelitis.

    • N-Heterocyclic Carbene-Silver(I) Complexes: Emerging Developments for Medicinal Applications

      https://doi.org/10.2174/0115734072349038250131050619
      Available online: 11 March 2025

      The increased applications of silver(I)-NHC complexes have led researchers to explore their medicinal studies and chemical properties. Silver(I) ions have proven to be considerable antimicrobial and anticancer agents, and their incorporation into various medical and associated fields has attracted immense attention. NHC-metal complexes have also been used as catalysts (homogeneous or heterogeneous) in developing various metal-based drugs. This has made them an increasingly popular choice since they provide favourable prerequisites for drug designing due to their great structural diversity, low toxic profile, and a multitude of chemical properties. It has been found that most of the silver(I)-NHC complexes have been more effective than their precursors. The results for various biological properties of imidazole and benzimidazole-based silver (I)-NHC complexes with functionalized and non-functionalized ligands have been summarized in this review. It will serve as a context guide for researchers studying Ag(I)-NHC complexes and their medicinal applications based on the status of research and trends over the past years.

    • Polyphenolics Profile of and Evaluation of its Hepatoprotective Potential

      https://doi.org/10.2174/0115734072368019250220042134
      Available online: 28 February 2025
      Background

      Paracetamol overdose can lead to severe liver damage due to the formation of toxic metabolites. , rich in polyphenols and flavonoids, and silymarin, a known liver protectant, may help mitigate this damage.

      Objective

      This study aims to characterize the main phytoconstituents of leaves and evaluate their hepatoprotective activity.

      Methods

      Leaves of were extracted with methanol. The total flavonoid and phenolic acid contents in the methanol extract were identified using HPLC. The hepatoprotective effects were assessed in 30 mice divided into five groups, treated with paracetamol to induce liver damage, and administered extract or silymarin at different doses. Blood and liver samples were collected to measure biochemical markers, oxidative stress indicators, inflammatory markers, and gene expression. Histopathological examination of liver tissues was also performed.

      Results

      HPLC analysis revealed a rich polyphenolic profile, with gallic acid (1905.83 µg/g) and diadzein (7039.18 µg/g) as predominant compounds. Paracetamol administration significantly increased TC, TG, liver enzyme levels (ALT, AST, LDH, ALP), MDA, IL-6, TNF-α, and CYP2E1, while decreasing HDL-c, SOD, GSH, and CAT levels, as well as BcL-2 and P53 gene expression, indicating hepatotoxicity. Treatment with extract and silymarin significantly mitigated these adverse effects, improving plasma lipid profiles, liver enzyme levels, oxidative stress biomarkers, inflammatory mediators, and gene expression. In addition, extract and silymarin significantly improve liver histopathological scores in paracetamol-treated mice. Despite severe congestion and necrosis, the liver maintained its typical structure with central veins and hepatocyte cords, highlighting the potential therapeutic benefits of these treatments.

      Conclusion

      extract and silymarin demonstrate significant hepatoprotective effects against paracetamol-induced liver damage. Their rich polyphenolic and flavonoid content effectively mitigates oxidative stress and inflammation, improving biochemical markers and preserving liver structure. These findings highlight their potential as therapeutic agents for liver health.

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